{"id":3882,"date":"2017-01-20T14:17:00","date_gmt":"2017-01-20T14:17:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=3882"},"modified":"2026-01-28T09:51:21","modified_gmt":"2026-01-28T09:51:21","slug":"new-paper-structure-guided-design-of-peptides","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2017\/01\/20\/new-paper-structure-guided-design-of-peptides\/","title":{"rendered":"New paper: Structure-guided design of peptides"},"content":{"rendered":"\n<p><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201700359\">Read our full paper open access<\/a><\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-4 is-cropped brgr gallery wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"580\" data-id=\"3888\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-1024x580.jpg\" alt=\"ToC: Cul2-based peptides\" class=\"wp-image-3888\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-1024x580.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-300x170.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-768x435.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-1536x870.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-2048x1160.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">ToC: Cul2-based peptides<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"401\" data-id=\"3887\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-1024x401.jpg\" alt=\"Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex\" class=\"wp-image-3887\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-1024x401.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-300x117.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-768x301.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-1536x601.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-2048x802.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\">Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"3908\" height=\"3533\" data-id=\"3886\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0.jpg\" alt=\"Figure 2 \u2013 Biolayer interferometry data of N-terminal Cul2 peptides versus VBC.\" class=\"wp-image-3886\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0.jpg 3908w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0-300x271.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0-1024x926.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0-768x694.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0-1536x1389.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0-2048x1851.jpg 2048w\" sizes=\"auto, (max-width: 3908px) 100vw, 3908px\" \/><figcaption class=\"wp-element-caption\">Figure 2 \u2013 Biolayer interferometry data of N-terminal Cul2 peptides versus VBC.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1700\" height=\"2000\" data-id=\"3884\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3.jpg\" alt=\"Figure 3 \u2013 Biophysical characterization of peptide J binding to VBC\" class=\"wp-image-3884\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3.jpg 1700w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3-255x300.jpg 255w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3-870x1024.jpg 870w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3-768x904.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3-1306x1536.jpg 1306w\" sizes=\"auto, (max-width: 1700px) 100vw, 1700px\" \/><figcaption class=\"wp-element-caption\">Figure 3 \u2013 Biophysical characterization of peptide J binding to VBC<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"461\" height=\"1024\" data-id=\"3885\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-461x1024.jpg\" alt=\"Table 1 \u2013 Results from the BLI experiment with the peptide variants replacing Leu3.\" class=\"wp-image-3885\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-461x1024.jpg 461w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-135x300.jpg 135w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-768x1705.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-692x1536.jpg 692w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-923x2048.jpg 923w\" sizes=\"auto, (max-width: 461px) 100vw, 461px\" \/><figcaption class=\"wp-element-caption\">Table 1 \u2013 Results from the BLI experiment with the peptide variants replacing Leu3.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"904\" height=\"1024\" data-id=\"3883\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-904x1024.jpg\" alt=\"Figure 4 \u2013 Chemical shift perturbation analysis by NMR spectroscopy.\" class=\"wp-image-3883\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-904x1024.jpg 904w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-265x300.jpg 265w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-768x870.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-1355x1536.jpg 1355w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4.jpg 1500w\" sizes=\"auto, (max-width: 904px) 100vw, 904px\" \/><figcaption class=\"wp-element-caption\">Figure 4 \u2013 Chemical shift perturbation analysis by NMR spectroscopy.<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Read our full paper open access<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3882","post","type-post","status-publish","format-standard","hentry","category-19"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3882"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882\/revisions"}],"predecessor-version":[{"id":4953,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882\/revisions\/4953"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=3882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=3882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}