{"id":3882,"date":"2017-01-20T14:17:00","date_gmt":"2017-01-20T14:17:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=3882"},"modified":"2026-01-28T09:51:21","modified_gmt":"2026-01-28T09:51:21","slug":"new-paper-structure-guided-design-of-peptides","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2017\/01\/20\/new-paper-structure-guided-design-of-peptides\/","title":{"rendered":"New paper: Structure-guided design of peptides"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/chemistry-europe.onlinelibrary.wiley.com\/doi\/10.1002\/cmdc.201700359\">Read our full paper open access<\/a><\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-4 is-cropped brgr gallery wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3888\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Tableofcontents-1024x580.jpg\" alt=\"ToC: Cul2-based peptides\" class=\"wp-image-3888\"\/><figcaption class=\"wp-element-caption\">ToC: Cul2-based peptides<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3887\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-1_0-1024x401.jpg\" alt=\"Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex\" class=\"wp-image-3887\"\/><figcaption class=\"wp-element-caption\">Figure 1. A) N-terminal tail in the Cullin family. B) The CRL2VHL complex<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-id=\"3886\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Figure-2_0.jpg\" alt=\"Figure 2 \u2013 Biolayer interferometry data of N-terminal Cul2 peptides versus VBC.\" class=\"wp-image-3886\"\/><figcaption class=\"wp-element-caption\">Figure 2 \u2013 Biolayer interferometry data of N-terminal Cul2 peptides versus VBC.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" data-id=\"3884\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-3.jpg\" alt=\"Figure 3 \u2013 Biophysical characterization of peptide J binding to VBC\" class=\"wp-image-3884\"\/><figcaption class=\"wp-element-caption\">Figure 3 \u2013 Biophysical characterization of peptide J binding to VBC<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3885\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/Table1-461x1024.jpg\" alt=\"Table 1 \u2013 Results from the BLI experiment with the peptide variants replacing Leu3.\" class=\"wp-image-3885\"\/><figcaption class=\"wp-element-caption\">Table 1 \u2013 Results from the BLI experiment with the peptide variants replacing Leu3.<\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"3883\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2025\/01\/FIGURE-4-904x1024.jpg\" alt=\"Figure 4 \u2013 Chemical shift perturbation analysis by NMR spectroscopy.\" class=\"wp-image-3883\"\/><figcaption class=\"wp-element-caption\">Figure 4 \u2013 Chemical shift perturbation analysis by NMR spectroscopy.<\/figcaption><\/figure>\n<\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Read our full paper open access<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3882","post","type-post","status-publish","format-standard","hentry","category-19"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3882"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882\/revisions"}],"predecessor-version":[{"id":4953,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/3882\/revisions\/4953"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3882"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=3882"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=3882"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}