{"id":2872,"date":"2013-12-04T16:51:00","date_gmt":"2013-12-04T16:51:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2872"},"modified":"2026-01-26T17:02:07","modified_gmt":"2026-01-26T17:02:07","slug":"targeting-the-low-druggability-baz2b-bromodomain-using-fragment-based-drug-design","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2013\/12\/04\/targeting-the-low-druggability-baz2b-bromodomain-using-fragment-based-drug-design\/","title":{"rendered":"Targeting the low-druggability BAZ2B bromodomain using fragment-based drug design"},"content":{"rendered":"\n

Our paper targeting the low-druggability BAZ2B bromodomain using fragment-based drug design is now published in J. Med. Chem.<\/p>\n\n\n\n

You can read our paper open-access<\/a>.<\/p>\n\n\n\n

\n
\"Table
Table 1. Structures, IC50 Values Determined by AlphaScreen, and Ligand Efficiencies of Validated Fragment Hits<\/figcaption><\/figure>\n\n\n\n
\"Figure
Figure 2. Overlay of the crystal structures of fragments 3 (shown pink) and 6 (shown cyan) illustrates the rationale for fragment merging<\/figcaption><\/figure>\n\n\n\n
\"Figure
Figure 1. Crystal Structures of the BAZ2B bromodomain in complex with (a) acetyllysine PDB 4NR9, (b) 1 PDB 4NRB, (c) 3 PDB 4NRC, and (d) 6 PDB 4NRA<\/figcaption><\/figure>\n\n\n\n
\"Table
Table of content graphic for targeting low drugability<\/figcaption><\/figure>\n<\/figure>\n","protected":false},"excerpt":{"rendered":"

Our paper targeting the low-druggability BAZ2B bromodomain using fragment-based drug design is now published in J. Med. Chem. You can read our paper open-access.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,4],"tags":[],"class_list":["post-2872","post","type-post","status-publish","format-standard","hentry","category-16","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2872","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2872"}],"version-history":[{"count":3,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2872\/revisions"}],"predecessor-version":[{"id":4903,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2872\/revisions\/4903"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2872"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2872"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2872"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}