{"id":2840,"date":"2014-08-27T15:34:00","date_gmt":"2014-08-27T14:34:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2840"},"modified":"2026-01-26T16:28:06","modified_gmt":"2026-01-26T16:28:06","slug":"nmr-approaches-in-structure-based-lead-discovery-for-targeting-multi-protein-complexes","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2014\/08\/27\/nmr-approaches-in-structure-based-lead-discovery-for-targeting-multi-protein-complexes\/","title":{"rendered":"NMR approaches in structure-based lead discovery for targeting multi-protein complexes"},"content":{"rendered":"<p>Our review on NMR approaches in structure-based lead discovery for targeting multi-protein complexes is now published in Prog. Biophys. Mol. Biol.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.pbiomolbio.2014.08.012\">You can read our paper open-access\u00a0<\/a>.<\/p>\n<div id='gallery-1' class='gallery galleryid-2840 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig1.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"622\" height=\"994\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig1.jpg\" class=\"attachment-large size-large\" alt=\"Figure 1. Representative NMR techniques used for hit generation\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig1.jpg 622w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig1-188x300.jpg 188w\" sizes=\"auto, (max-width: 622px) 100vw, 622px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"622\" height=\"421\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig2.jpg\" class=\"attachment-large size-large\" alt=\"Figure 2. Schematic representation of the stepwise approach of SAR by NMR\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig2.jpg 622w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig2-300x203.jpg 300w\" sizes=\"auto, (max-width: 622px) 100vw, 622px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig3.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"533\" height=\"1012\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig3.jpg\" class=\"attachment-large size-large\" alt=\"Figure 3. NMR techniques used to study ligand-bound conformation and protein binding sites identification\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig3.jpg 533w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig3-158x300.jpg 158w\" sizes=\"auto, (max-width: 533px) 100vw, 533px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig4.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"578\" height=\"604\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig4.jpg\" class=\"attachment-large size-large\" alt=\"Figure 4. Isotopic labelling strategies to aid NMR studies of multi-protein targets.\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig4.jpg 578w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig4-287x300.jpg 287w\" sizes=\"auto, (max-width: 578px) 100vw, 578px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig5.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"711\" height=\"541\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig5.jpg\" class=\"attachment-large size-large\" alt=\"Figure 5. Different labelling schemes and respective spectra in von Hippel-Lindau protein (pVHL) E3 ubiquitin ligase multi-subunit complex\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig5.jpg 711w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig5-300x228.jpg 300w\" sizes=\"auto, (max-width: 711px) 100vw, 711px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig6.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"533\" height=\"403\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig6.jpg\" class=\"attachment-large size-large\" alt=\"\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig6.jpg 533w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/NMR-structure-based-lead-complexes-Fig6-300x227.jpg 300w\" sizes=\"auto, (max-width: 533px) 100vw, 533px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Our review on NMR approaches in structure-based lead discovery for targeting multi-protein complexes is now published in Prog. Biophys. Mol. Biol. You can read our paper open-access\u00a0.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,4],"tags":[],"class_list":["post-2840","post","type-post","status-publish","format-standard","hentry","category-22","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2840","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2840"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2840\/revisions"}],"predecessor-version":[{"id":4889,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2840\/revisions\/4889"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2840"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2840"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2840"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}