{"id":2752,"date":"2014-12-18T15:25:00","date_gmt":"2014-12-18T15:25:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2752"},"modified":"2026-01-26T16:28:05","modified_gmt":"2026-01-26T16:28:05","slug":"structural-basis-of-histone-tail-recognition-by-human-baz2a-tip5-and-baz2b-epigenetic-reader-domains-phd-finger-and-bromodomain","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2014\/12\/18\/structural-basis-of-histone-tail-recognition-by-human-baz2a-tip5-and-baz2b-epigenetic-reader-domains-phd-finger-and-bromodomain\/","title":{"rendered":"Structural basis of histone tail recognition by human BAZ2A (TIP5) and BAZ2B epigenetic reader domains PHD finger and bromodomain"},"content":{"rendered":"<p>Our paper on structural basis of histone tail recognition by human BAZ2A (TIP5) and BAZ2B epigenetic reader domains PHD finger and bromodomain now published in Structure.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.str.2014.10.017\" data-type=\"link\" data-id=\"http:\/\/dx.doi.org\/10.1016\/j.str.2014.10.017\">Read our Open Access full-text article<\/a><\/p>\n<div id='gallery-1' class='gallery galleryid-2752 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-1024x1024.jpg\" class=\"attachment-large size-large\" alt=\"Graphical abstract for the paper on BAZ2A (TIP5) and BAZ2B\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-1024x1024.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-300x300.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-150x150.jpg 150w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-768x768.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac-1536x1536.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Graphical_Abstract2-ac.jpg 1650w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"485\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-1024x485.jpg\" class=\"attachment-large size-large\" alt=\"Figure 1. Domain Organization of Human Chromatin Associated Proteins Containing PHD Zinc Fingers Adjacent to BRDs\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-1024x485.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-300x142.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-768x364.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-1536x728.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-1-2048x970.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-1024x576.jpg\" class=\"attachment-large size-large\" alt=\"Figure 2. Structures of TIP5 and BAZ2B PHD Zinc Fingers in Free State and in Complex with H3K4 Peptide\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-1024x576.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-300x169.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-768x432.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-1536x864.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-2-2048x1152.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"841\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-841x1024.jpg\" class=\"attachment-large size-large\" alt=\"Figure 3. Structures of TIP5 and BAZ2B BRDs in the Free State and in Complex with H3 and H4 Peptides\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-841x1024.jpg 841w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-246x300.jpg 246w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-768x935.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-1262x1536.jpg 1262w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-3-1683x2048.jpg 1683w\" sizes=\"auto, (max-width: 841px) 100vw, 841px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"728\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-1024x728.jpg\" class=\"attachment-large size-large\" alt=\"Figure 4. ITC-Based Binding Curves of Individual BRDs with Histone Peptides and Further Analysis on the Specificity of the Recognition Sequence Kac-X-X-R\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-1024x728.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-300x213.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-768x546.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-1536x1092.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-4-copy-2-2048x1456.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"885\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5-1024x885.jpg\" class=\"attachment-large size-large\" alt=\"Figure 5. SAXS Analyses Are Shown for Tandem TIP5 PHD-BRD and BAZ2B PHD-BRD in the Free State\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5-1024x885.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5-300x259.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5-768x664.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5-1536x1327.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/BAZ2A-TIP5-and-BAZ2B-Figure-5.jpg 1934w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Our paper on structural basis of histone tail recognition by human BAZ2A (TIP5) and BAZ2B epigenetic reader domains PHD finger and bromodomain now published in Structure. Read our Open Access full-text article<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22,4],"tags":[],"class_list":["post-2752","post","type-post","status-publish","format-standard","hentry","category-22","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2752","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2752"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2752\/revisions"}],"predecessor-version":[{"id":4881,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2752\/revisions\/4881"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2752"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2752"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2752"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}