{"id":2749,"date":"2015-04-17T15:16:00","date_gmt":"2015-04-17T14:16:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2749"},"modified":"2026-01-26T16:28:05","modified_gmt":"2026-01-26T16:28:05","slug":"structure-protein-protein-interactions-and-drug-discovery-targeting-cullin-ring-e3-ubiquitin-ligases","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2015\/04\/17\/structure-protein-protein-interactions-and-drug-discovery-targeting-cullin-ring-e3-ubiquitin-ligases\/","title":{"rendered":"Structure, protein-protein interactions and drug discovery targeting Cullin RING E3 Ubiquitin Ligases"},"content":{"rendered":"<p>Our review on structure, protein-protein interactions and drug discovery targeting Cullin RING E3 Ubiquitin Ligases is now published in the Biochemical Journal.<\/p>\n<p><a href=\"http:\/\/www.biochemj.org\/content\/467\/3\/365\">You can read our paper Open Access<\/a>.<\/p>\n<div id='gallery-1' class='gallery galleryid-2749 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-BJ_cover-copy-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"666\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-BJ_cover-copy-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Biochemical Journal front page for structure protein-protein interaction article\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure01-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"371\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure01-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 1 Cullin RING E3 ubiquitin ligases\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure02-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"392\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure02-scaled.jpg\" class=\"attachment-large size-large\" alt=\"&quot;Figure 2 Assembly between substrate receptor \u2018box\u2019 domains and adaptor subunits\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure03-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"291\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure03-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 3 Assembly between adaptor subunits and Cullins\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure04-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"638\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure04-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 4 Chemical structures of published small-molecule modulators of CRL activity\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure05-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"568\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure05-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 5 Crystal structure of Skp1\u2013Cdc4\u2013SCF-I2 complex (PDB code 3MKS)\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure06-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"606\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure06-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 6 Crystal structure of the Skp1\u2013TIR1\u2013Probe 8 complex (PDB code 3C6N)&quot;\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure07-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"491\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure07-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 7 Crystal structure of the VHL\u2013ElonginB\u2013ElonginC\u2013Compound 7 complex (PDB code 4W9H)\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure08-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"493\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure08-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 8 Crystal structure of the Keap1\u2013SRS-59 complex (PDB code 4L7D)\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure09-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"625\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure09-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 9 Crystal structure of the Keap1\u2013Cpd16 complex (PDB code 4IQK)\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure10-top-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"360\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure10-top-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 10 Crystal structure of the CRBN\u2013DDB1\u2013thalidomide complex (PDB code 4CI1)\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure10-bottom-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"409\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure10-bottom-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 11 (top) Structures of CC0651 bound to an allosteric pocket on the E2-conjugating enzyme Cdc34\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure11-scaled.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"538\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Figure11-scaled.jpg\" class=\"attachment-large size-large\" alt=\"Figure 11 (bottom) Structures of CC0651 bound to an allosteric pocket on the E2-conjugating enzyme Cdc34\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Scheme01.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"843\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/structure-protein-interactions-Scheme01.jpg\" class=\"attachment-large size-large\" alt=\"Figure 12 Crystal structure of the NAE1\u2013UBA3\u2013NEDD8\u223cMLN4924 complex (PDB code 3GZN)\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Our review on structure, protein-protein interactions and drug discovery targeting Cullin RING E3 Ubiquitin Ligases is now published in the Biochemical Journal. You can read our paper Open Access.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[21,4],"tags":[],"class_list":["post-2749","post","type-post","status-publish","format-standard","hentry","category-21","category-news"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":7}},"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2749"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2749\/revisions"}],"predecessor-version":[{"id":4880,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2749\/revisions\/4880"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}