{"id":2630,"date":"2016-05-19T10:15:00","date_gmt":"2016-05-19T09:15:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2630"},"modified":"2026-01-26T16:28:05","modified_gmt":"2026-01-26T16:28:05","slug":"selectivity-of-chemical-probes-targeting-bromodomains","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2016\/05\/19\/selectivity-of-chemical-probes-targeting-bromodomains\/","title":{"rendered":"Selectivity of chemical probes targeting bromodomains\u00a0"},"content":{"rendered":"<p>Our review on selectivity of chemical probes targeting bromodomains is now published in Future Medicinal Chemistry.<\/p>\n<p><a href=\"http:\/\/10.0.16.59\/fmc-2016-0059\">Read our open access review without restriction\u00a0<\/a>.<\/p>\n<div id='gallery-1' class='gallery galleryid-2630 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"826\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36-1024x826.png\" class=\"attachment-large size-large\" alt=\"Front page of Medicinal Chemistry screenshot for the article selectivity of chemical probes targeting bromodomains\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36-1024x826.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36-300x242.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36-768x620.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36-1536x1239.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/selectivity-of-chemical-probes-targeting-bromodomains-Screen-Shot-2016-05-21-at-17.15.36.png 1666w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"526\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of-1024x526.png\" class=\"attachment-large size-large\" alt=\"Figure 2. Structure and molecular recognition of BET bromodomains\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of-1024x526.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of-300x154.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of-768x394.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of-1536x789.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-2-Structure-and-molecular-recognition-of-BET-bromodomains-A-x-ray-structure-of.png 1655w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains.jpeg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"762\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-1024x762.jpeg\" class=\"attachment-large size-large\" alt=\"Figure 3.CREBBP\/EP300 bromodomain\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-1024x762.jpeg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-300x223.jpeg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-768x572.jpeg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-1536x1144.jpeg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/figure3-selectivity-of-chemical-probes-targeting-bromodomains-2048x1525.jpeg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-4-BRD9-bromodomain-A-Superposition-of-the-x-ray-structure-of-BRD9-in-orange.png'><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"756\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-4-BRD9-bromodomain-A-Superposition-of-the-x-ray-structure-of-BRD9-in-orange.png\" class=\"attachment-large size-large\" alt=\"Figure 4. BRD9 bromodomain\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-4-BRD9-bromodomain-A-Superposition-of-the-x-ray-structure-of-BRD9-in-orange.png 850w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-4-BRD9-bromodomain-A-Superposition-of-the-x-ray-structure-of-BRD9-in-orange-300x267.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-4-BRD9-bromodomain-A-Superposition-of-the-x-ray-structure-of-BRD9-in-orange-768x683.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-5-BAZ2B-bromodomain-A-Superposition-of-the-x-ray-structure-of-BAZ2B-in-green.png'><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"633\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-5-BAZ2B-bromodomain-A-Superposition-of-the-x-ray-structure-of-BAZ2B-in-green.png\" class=\"attachment-large size-large\" alt=\"Figure 5. BAZ2B bromodomain\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-5-BAZ2B-bromodomain-A-Superposition-of-the-x-ray-structure-of-BAZ2B-in-green.png 850w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-5-BAZ2B-bromodomain-A-Superposition-of-the-x-ray-structure-of-BAZ2B-in-green-300x223.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-5-BAZ2B-bromodomain-A-Superposition-of-the-x-ray-structure-of-BAZ2B-in-green-768x572.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-7-BRPF-and-ATAD2-bromodomains-A-Superposition-of-the-x-ray-structures-of.png'><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"378\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-7-BRPF-and-ATAD2-bromodomains-A-Superposition-of-the-x-ray-structures-of.png\" class=\"attachment-large size-large\" alt=\"Figure 7. BRPF and ATAD2 bromodomains\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-7-BRPF-and-ATAD2-bromodomains-A-Superposition-of-the-x-ray-structures-of.png 850w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-7-BRPF-and-ATAD2-bromodomains-A-Superposition-of-the-x-ray-structures-of-300x133.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-7-BRPF-and-ATAD2-bromodomains-A-Superposition-of-the-x-ray-structures-of-768x342.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-8-Selectivity-between-BD1-and-BD2-BET-bromodomains-A-Superposition-of-the.png'><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"817\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-8-Selectivity-between-BD1-and-BD2-BET-bromodomains-A-Superposition-of-the.png\" class=\"attachment-large size-large\" alt=\"Figure 8. Selectivity between BD1 and BD2 BET bromodomains\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-8-Selectivity-between-BD1-and-BD2-BET-bromodomains-A-Superposition-of-the.png 850w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-8-Selectivity-between-BD1-and-BD2-BET-bromodomains-A-Superposition-of-the-300x288.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-8-Selectivity-between-BD1-and-BD2-BET-bromodomains-A-Superposition-of-the-768x738.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-9-Bump-and-hole-approach-Superposition-of-the-x-ray-structure-of-the-ET-in.png'><img loading=\"lazy\" decoding=\"async\" width=\"850\" height=\"496\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-9-Bump-and-hole-approach-Superposition-of-the-x-ray-structure-of-the-ET-in.png\" class=\"attachment-large size-large\" alt=\"Figure 9. Bump-and-hole approach\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-9-Bump-and-hole-approach-Superposition-of-the-x-ray-structure-of-the-ET-in.png 850w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-9-Bump-and-hole-approach-Superposition-of-the-x-ray-structure-of-the-ET-in-300x175.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-9-Bump-and-hole-approach-Superposition-of-the-x-ray-structure-of-the-ET-in-768x448.png 768w\" sizes=\"auto, (max-width: 850px) 100vw, 850px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-10-Dual-bromodomainkinase-inhibitors-x-ray-structure-of-the-dinaciclib-in.png'><img loading=\"lazy\" decoding=\"async\" width=\"827\" height=\"615\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-10-Dual-bromodomainkinase-inhibitors-x-ray-structure-of-the-dinaciclib-in.png\" class=\"attachment-large size-large\" alt=\"Figure 10. Dual bromodomain\/kinase inhibitors.\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-10-Dual-bromodomainkinase-inhibitors-x-ray-structure-of-the-dinaciclib-in.png 827w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-10-Dual-bromodomainkinase-inhibitors-x-ray-structure-of-the-dinaciclib-in-300x223.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Figure-10-Dual-bromodomainkinase-inhibitors-x-ray-structure-of-the-dinaciclib-in-768x571.png 768w\" sizes=\"auto, (max-width: 827px) 100vw, 827px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Our review on selectivity of chemical probes targeting bromodomains is now published in Future Medicinal Chemistry. Read our open access review without restriction\u00a0.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,4],"tags":[],"class_list":["post-2630","post","type-post","status-publish","format-standard","hentry","category-20","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2630"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2630\/revisions"}],"predecessor-version":[{"id":4873,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2630\/revisions\/4873"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}