{"id":2620,"date":"2016-07-13T10:05:00","date_gmt":"2016-07-13T09:05:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2620"},"modified":"2026-01-26T16:28:05","modified_gmt":"2026-01-26T16:28:05","slug":"advanced-chemical-genetics-for-epigenetics","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2016\/07\/13\/advanced-chemical-genetics-for-epigenetics\/","title":{"rendered":"Advanced chemical genetics for epigenetics"},"content":{"rendered":"

Our review on advanced chemical genetics for epigenetics is now published in Current Opinion in Chemical Biology!<\/p>\n

Well done Andrew, Kwok-Ho and Michael!<\/p>\n

Read our review open access<\/a>.<\/p>\n

Review synopsis<\/strong><\/h2>\n

\u00a0In conventional chemical genetics, cell-active small-molecules directly block protein activity, altering phenotype. However these molecules may not be sufficiently selective or effective at modulating complex epigenetic pathways. By mutating the target protein, and creating a mutant-selective inhibitor, the bump-and-hole approach can provide single-target selectivity. PROTAC molecules direct their target to proteosomal degradation by recruiting an E3 ubiquitin ligase, resulting in more efficacious target downregulation.<\/p>\n