{"id":2554,"date":"2017-03-13T11:27:00","date_gmt":"2017-03-13T11:27:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2554"},"modified":"2024-01-09T11:42:12","modified_gmt":"2024-01-09T11:42:12","slug":"first-ternary-crystal-structure-of-a-protac-bound-to-to-its-e3-ligase-vhl-and-brd4-target","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2017\/03\/13\/first-ternary-crystal-structure-of-a-protac-bound-to-to-its-e3-ligase-vhl-and-brd4-target\/","title":{"rendered":"First ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<p>Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology!<\/p>\n\n\n\n<p>Our work provides unprecedented insights into how PROTACs work.<\/p>\n\n\n\n<p>Congratulations to\u00a0Morgan,\u00a0Andrea,\u00a0Xavi\u00a0and\u00a0Kwok-Ho\u00a0for a fantastic team effort!\u00a0<\/p>\n\n\n\n<p>Read our paper PDF\u00a0<a href=\"http:\/\/rdcu.be\/p2RH\">SharedIT web page<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Related Links<\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2017-03\/uod-ako031017.php\" target=\"_blank\" rel=\"noreferrer noopener\">EurekaAlert: A kiss of death to drug the &#8216;undruggable&#8217;<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/phys.org\/news\/2017-03-death-drug-undruggable.html\" target=\"_blank\" rel=\"noreferrer noopener\">PhysOrg: A kiss of death to drug the &#8216;undruggable&#8217;<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/www.fiercebiotech.com\/research\/using-a-kiss-death-to-neutralize-disease-causing-proteins\" target=\"_blank\" rel=\"noreferrer noopener\">FierceBiotech: Using a \u2018kiss of death\u2019 to neutralize disease-causing proteins<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/www.dailymail.co.uk\/health\/article-4310716\/Cancer-breakthrough-Scientists-kill-undruggable-protein.html?ITO=1490&amp;ns_mchannel=rss&amp;ns_campaign=1490\" target=\"_blank\" rel=\"noreferrer noopener\">MailOnline: Cancer breakthrough: Scientists discover how to kill &#8216;undruggable&#8217; proteins using &#8216;the kiss of death&#8217;<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/www.express.co.uk\/news\/uk\/778766\/Scientists-discover-kiss-of-death-technique-to-destroy-cancer-disease?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A%20daily-express-uk-news%20%28Express%20%3A%3A%20UK%20Feed%29\" target=\"_blank\" rel=\"noreferrer noopener\">Express: A &#8216;KISS OF DEATH&#8217; technique could help fight against cancer, says scientists<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.thesun.co.uk\/living\/3080130\/cancer-could-be-wiped-out-after-scientists-discover-how-to-destroy-key-proteins-thought-to-be-untouchable\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Sun: KISS OF DEATH Cancer could be WIPED OUT after scientists discover how to destroy key proteins thought to be \u2018untouchable\u2019<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/scienmag.com\/a-kiss-of-death-to-drug-the-undruggable\/\" target=\"_blank\" rel=\"noreferrer noopener\">ScienMag: A kiss of death to drug the \u2018undruggable\u2019<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.sciencedaily.com\/releases\/2017\/03\/170313135028.htm\" target=\"_blank\" rel=\"noreferrer noopener\">Science Daily: A kiss of death to drug the \u2018undruggable\u2019<\/a><\/li>\n\n\n\n<li><a href=\"http:\/\/globalnews.ca\/news\/3309344\/scientist-discover-kiss-of-death-for-cancer-causing-proteins\/\" target=\"_blank\" rel=\"noreferrer noopener\">Global News: Scientists discover \u2018kiss of death\u2019 for cancer-causing proteins<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/www.youtube.com\/watch?v=NonpXK0CVcA\" target=\"_blank\" rel=\"noreferrer noopener\">Video: Scientist discover \u2018kiss of death\u2019 for cancer-causing proteins<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Our paper reporting the first ternary crystal structure of a PROTAC bound to to its E3 ligase VHL and Brd4 target is now published in Nature Chemical Biology! Our work provides unprecedented insights into how PROTACs work. Congratulations to\u00a0Morgan,\u00a0Andrea,\u00a0Xavi\u00a0and\u00a0Kwok-Ho\u00a0for a fantastic team effort!\u00a0 Read our paper PDF\u00a0SharedIT web page. Related Links<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19,4],"tags":[],"class_list":["post-2554","post","type-post","status-publish","format-standard","hentry","category-19","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2554","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2554"}],"version-history":[{"count":0,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2554\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2554"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2554"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2554"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}