{"id":2373,"date":"2019-06-10T14:06:00","date_gmt":"2019-06-10T13:06:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2373"},"modified":"2026-01-26T16:28:04","modified_gmt":"2026-01-26T16:28:04","slug":"dundee-and-boehringer-ingelheim-scientists-degrade-undruggable-cancer-targets-smarca2-4","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2019\/06\/10\/dundee-and-boehringer-ingelheim-scientists-degrade-undruggable-cancer-targets-smarca2-4\/","title":{"rendered":"Dundee and Boehringer Ingelheim scientists degrade undruggable cancer targets SMARCA2\/4"},"content":{"rendered":"<p><a href=\"https:\/\/rdcu.be\/bF6NK\">Read the article Open Access as SharedIt version<\/a><\/p>\n<p>Fantastic job Will, Manfred and team!<\/p>\n<p>Researchers can now access the SMARCA2\/4 degrader ACBI1 for their own research \u2013 order the molecule completely free of charge from\u00a0<a href=\"https:\/\/opnme.com\/molecules\/smarca2-4-acbi1?\">OpnMe<\/a>.<\/p>\n<h2 class=\"wp-block-heading\">Related Links<\/h2>\n<ul>\n<li><a href=\"https:\/\/www.dundee.ac.uk\/news\/2019\/boehringer-ingelheim-and-university-of-dundee-highlight-successful-protac-drug-discovery-program.php\" target=\"_blank\" rel=\"noreferrer noopener\">UoD PR: Boehringer Ingelheim and University of Dundee highlight successful PROTAC drug discovery program<\/a><\/li>\n<li><a href=\"https:\/\/www.boehringer-ingelheim.com\/press-release\/boehringer-ingelheim-extends-protac-discovery-program\" target=\"_blank\" rel=\"noreferrer noopener\">BI PR: Boehringer Ingelheim and University of Dundee Highlight Successful PROTAC Drug Discovery Program and Extend Their Ongoing Anti-Cancer Alliance<\/a><\/li>\n<li><a href=\"https:\/\/www.genengnews.com\/news\/protacs-developed-with-u-of-dundee-boost-boehringer-ingelheims-cancer-pipeline\/\" target=\"_blank\" rel=\"noreferrer noopener\">GenEngNews: PROTACs Developed with U. of Dundee Boost Boehringer Ingelheim\u2019s Cancer Pipeline<\/a><\/li>\n<li><a href=\"http:\/\/www.pharmatimes.com\/news\/boehringer,_uni_of_dundee_extend_anti-cancer_alliance_1291871\" target=\"_blank\" rel=\"noreferrer noopener\">PharmaTimes: Boehringer, Uni of Dundee extend anti-cancer alliance<\/a><\/li>\n<li><a href=\"https:\/\/opnme.com\/news\/acbi1-news-announcement\" target=\"_blank\" rel=\"noreferrer noopener\">We are proud to release the 3rd PROTAC degrader for free on opnMe: SMARCA2\/4 specific protein degrader ACBI1 to study the BAF chromatin remodeling complexes<\/a><\/li>\n<\/ul>\n<div id='gallery-1' class='gallery galleryid-2373 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"699\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-1024x699.png\" class=\"attachment-large size-large\" alt=\"Graphical abstract of SMARCA PROTAC\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-1024x699.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-300x205.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-768x524.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-1536x1048.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4.png 1691w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"643\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-1024x643.png\" class=\"attachment-large size-large\" alt=\"Fig. 1: Rational design and evaluation of a partial degrader of SMARCA2 and SMARCA4, PROTAC 1\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-1024x643.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-300x188.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-768x482.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-1536x964.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract_0-SMARCA2-4-figure1-2048x1285.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"816\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0-1024x816.jpg\" class=\"attachment-large size-large\" alt=\"Fig. 2: Ternary co-crystal structure of SMARCA2BD:PROTAC 1:VCB\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0-1024x816.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0-300x239.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0-768x612.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0-1536x1224.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig2_0.jpg 1816w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"804\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-1024x804.png\" class=\"attachment-large size-large\" alt=\"Fig. 3: Ternary co-crystal structure of SMARCA2BD:PROTAC 2:VCB and biophysical data validate a rational design strategy\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-1024x804.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-300x235.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-768x603.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-1536x1206.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig3_2-2048x1607.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"818\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-1024x818.jpg\" class=\"attachment-large size-large\" alt=\"Fig. 4: ACBI1 is a potent and selective degrader of SMARCA2, SMARCA4 and PBRM1\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-1024x818.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-300x240.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-768x614.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-1536x1227.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig4_0-2048x1636.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0.jpg'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"570\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-1024x570.jpg\" class=\"attachment-large size-large\" alt=\"Fig. 5: Effects on the proliferation and apoptosis of cancer cells in the presence of ACBI1\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-1024x570.jpg 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-300x167.jpg 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-768x427.jpg 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-1536x854.jpg 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/SMARCA2-4-Fig5_0-2048x1139.jpg 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Read the article Open Access as SharedIt version Fantastic job Will, Manfred and team! Researchers can now access the SMARCA2\/4 degrader ACBI1 for their own research \u2013 order the molecule completely free of charge from\u00a0OpnMe. Related Links UoD PR: Boehringer Ingelheim and University of Dundee highlight successful PROTAC drug discovery program BI PR: Boehringer Ingelheim [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,4],"tags":[],"class_list":["post-2373","post","type-post","status-publish","format-standard","hentry","category-17","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2373","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2373"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2373\/revisions"}],"predecessor-version":[{"id":4861,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2373\/revisions\/4861"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2373"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2373"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2373"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}