{"id":2215,"date":"2021-03-30T14:52:00","date_gmt":"2021-03-30T13:52:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2215"},"modified":"2026-01-26T15:07:00","modified_gmt":"2026-01-26T15:07:00","slug":"review-on-the-present-and-future-of-protacs-for-cancer-therapy","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2021\/03\/30\/review-on-the-present-and-future-of-protacs-for-cancer-therapy\/","title":{"rendered":"Review on the present and future of PROTACs for cancer therapy"},"content":{"rendered":"<p>Will and Manfred\u2019s review on the present and future of PROTACs for cancer therapy is now out in Current Opinion in Pharmacology<\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1471489221000205?dgcid=coauthor\">Read the full article.<\/a><\/p>\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"724\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2024\/01\/Graphical-abstract-1-1024x724.jpg\" alt=\"Graphic showing scales with 3 bottles of PROTAC on one side and  2 bottles of classic inhibitor on the other site\"><\/figure>\n<p>Authors: William Farnaby*, Manfred Koegl*, Darryl B. McConnell, Alessio Ciulli<\/p>\n<p>Title: Transforming targeted cancer therapy with PROTACs: A forward-looking perspective<\/p>\n<p>Highlights:<\/p>\n<ul>\n<li>Targeted protein degradation approaches can address key cancer therapy challenges.<\/li>\n<li>Previously undrugged, genetically validated targets can be prosecuted with PROTACs.<\/li>\n<li>PROTACs can address some known drug resistance mechanisms but may have their own.<\/li>\n<li>Target selectivity well beyond that achievable with inhibitors is possible.<\/li>\n<li>Tissue specificity due to differential E3 ligase activity holds much promise.<\/li>\n<\/ul>\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n<p>Small-molecule targeted protein degraders have in recent years made a great impact on the strategies of many industry and academic cancer research endeavours. We seek here to provide a concise perspective on the opportunities and challenges that lie ahead for bifunctional degrader molecules, so-called \u2018Proteolysis Targeting Chimeras (PROTACs),\u2019 in the context of cancer therapy. We highlight high-profile studies that support the potential for PROTAC approaches to broaden drug target scope, address drug resistance, enhance target selectivity and provide tissue specificity, but also assess where the modality is yet to fully deliver in these contexts. Future opportunities presented by the unique bifunctional nature of these molecules are also discussed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Will and Manfred\u2019s review on the present and future of PROTACs for cancer therapy is now out in Current Opinion in Pharmacology Read the full article. Authors: William Farnaby*, Manfred Koegl*, Darryl B. McConnell, Alessio Ciulli Title: Transforming targeted cancer therapy with PROTACs: A forward-looking perspective Highlights: Targeted protein degradation approaches can address key cancer [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14,4],"tags":[],"class_list":["post-2215","post","type-post","status-publish","format-standard","hentry","category-14","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2215"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2215\/revisions"}],"predecessor-version":[{"id":4752,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2215\/revisions\/4752"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}