{"id":2115,"date":"2019-10-06T15:58:00","date_gmt":"2019-10-06T14:58:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2115"},"modified":"2026-01-26T16:28:04","modified_gmt":"2026-01-26T16:28:04","slug":"e3-ligase-socs2","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2019\/10\/06\/e3-ligase-socs2\/","title":{"rendered":"Structure of the E3 ligase SOCS2 with bound substrate"},"content":{"rendered":"<figure class=\"wp-block-image size-large\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"481\" height=\"331\" data-id=\"2107\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2024\/01\/PSX_20190610_112555-copy.jpg\" alt=\"The article's joint co-authors: Sarath Ramachandran, Wei-Wei Kung and Nikolai Makukhin\"><\/figure>\n<\/figure>\n<p>Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates.<\/p>\n<p>Read full article on <a href=\"https:\/\/www.nature.com\/articles\/s41467-019-10190-4\" data-type=\"link\" data-id=\"https:\/\/www.nature.com\/articles\/s41467-019-10190-4\">Nature Communications website<\/a>.<\/p>\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<div class=\"wp-block-group is-nowrap is-layout-flex wp-container-core-group-is-layout-ad2f72ca wp-block-group-is-layout-flex\">\n<p>Read University of Dundee press release: \u201c<a href=\"https:\/\/www.dundee.ac.uk\/stories\/ciulli-lab-reveals-how-e3-ligase-socs2-latches-its-protein-substrates\">Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates<\/a>\u201c<\/p>\n<\/div>\n<\/div>\n<div id='gallery-1' class='gallery galleryid-2115 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal.png'><img loading=\"lazy\" decoding=\"async\" width=\"830\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal-830x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 1. Structural and interaction detail of the SBC-EpoR co-crystal\" aria-describedby=\"gallery-1-2108\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal-830x1024.png 830w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal-243x300.png 243w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal-768x947.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig1_0-SSBC-EpoR-co-crystal.png 900w\" sizes=\"auto, (max-width: 830px) 100vw, 830px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2108'>\n\t\t\t\tFigure 1. Structural and interaction detail of the SBC-EpoR co-crystal\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure.png'><img loading=\"lazy\" decoding=\"async\" width=\"813\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure-813x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 2. Structural and interaction detail of the SBC-GHR co-crystal structure\" aria-describedby=\"gallery-1-2109\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure-813x1024.png 813w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure-238x300.png 238w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure-768x968.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig2-SBC-GHR-co-crystal-structure.png 900w\" sizes=\"auto, (max-width: 813px) 100vw, 813px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2109'>\n\t\t\t\tFigure 2. Structural and interaction detail of the SBC-GHR co-crystal structure\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2.png'><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"903\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2.png\" class=\"attachment-large size-large\" alt=\"Figure 3. The BG loop of SOCS2\" aria-describedby=\"gallery-1-2110\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2.png 900w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2-300x300.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2-150x150.png 150w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig3-BG-loop-of-SOCS2-768x771.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2110'>\n\t\t\t\tFigure 3. The BG loop of SOCS2\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig4-EF-and-BG-loops.png'><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"769\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig4-EF-and-BG-loops.png\" class=\"attachment-large size-large\" alt=\"Figure 4. Conformational changes of the EF and BG loops\" aria-describedby=\"gallery-1-2111\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig4-EF-and-BG-loops.png 900w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig4-EF-and-BG-loops-300x256.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig4-EF-and-BG-loops-768x656.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2111'>\n\t\t\t\tFigure 4. Conformational changes of the EF and BG loops\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig5_0-Two-models-of-SOCS2-substrate-receptor-recruitment.png'><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"432\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig5_0-Two-models-of-SOCS2-substrate-receptor-recruitment.png\" class=\"attachment-large size-large\" alt=\"Figure 5. Position and characterization of SNPs of SOCS2\" aria-describedby=\"gallery-1-2112\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig5_0-Two-models-of-SOCS2-substrate-receptor-recruitment.png 900w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig5_0-Two-models-of-SOCS2-substrate-receptor-recruitment-300x144.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig5_0-Two-models-of-SOCS2-substrate-receptor-recruitment-768x369.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2112'>\n\t\t\t\tFigure 5. Position and characterization of SNPs of SOCS2\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig6-GHR-and-EpoR-binding.png'><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"782\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig6-GHR-and-EpoR-binding.png\" class=\"attachment-large size-large\" alt=\"Figure 6. Comparison of the GHR and EpoR binding\" aria-describedby=\"gallery-1-2113\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig6-GHR-and-EpoR-binding.png 900w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig6-GHR-and-EpoR-binding-300x261.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig6-GHR-and-EpoR-binding-768x667.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2113'>\n\t\t\t\tFigure 6. Comparison of the GHR and EpoR binding\n\t\t\t\t<\/figcaption><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig7-models-of-SOCS2-substrate-receptor-recruitment.png'><img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"516\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig7-models-of-SOCS2-substrate-receptor-recruitment.png\" class=\"attachment-large size-large\" alt=\"Figure 7. Two models of SOCS2-substrate receptor recruitment\" aria-describedby=\"gallery-1-2114\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig7-models-of-SOCS2-substrate-receptor-recruitment.png 900w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig7-models-of-SOCS2-substrate-receptor-recruitment-300x172.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2024\/01\/fig7-models-of-SOCS2-substrate-receptor-recruitment-768x440.png 768w\" sizes=\"auto, (max-width: 900px) 100vw, 900px\" \/><\/a>\n\t\t\t<\/div>\n\t\t\t\t<figcaption class='wp-caption-text gallery-caption' id='gallery-1-2114'>\n\t\t\t\tFigure 7. Two models of SOCS2-substrate receptor recruitment\n\t\t\t\t<\/figcaption><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Ciulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates. Read full article on Nature Communications website. Read University of Dundee press release: \u201cCiulli Lab reveals how the E3 ligase SOCS2 latches on to its protein substrates\u201c<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,4],"tags":[],"class_list":["post-2115","post","type-post","status-publish","format-standard","hentry","category-17","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2115","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2115"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2115\/revisions"}],"predecessor-version":[{"id":4858,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2115\/revisions\/4858"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2115"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2115"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2115"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}