{"id":2037,"date":"2013-12-06T14:58:00","date_gmt":"2013-12-06T14:58:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2037"},"modified":"2026-01-26T16:28:06","modified_gmt":"2026-01-26T16:28:06","slug":"biophysical-screening-for-the-discovery-of-small-molecule-ligands","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2013\/12\/06\/biophysical-screening-for-the-discovery-of-small-molecule-ligands\/","title":{"rendered":"Biophysical Screening for the Discovery of Small-Molecule Ligands"},"content":{"rendered":"<p>Alessio\u2019s book chapter \u201cBiophysical Screening for the Discovery of Small-Molecule Ligands\u201d is now published in Methods Mol. Biol<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1007\/978-1-62703-398-5_13\" data-type=\"link\" data-id=\"https:\/\/link.springer.com\/protocol\/10.1007\/978-1-62703-398-5_13\">Read the full chapter<\/a>.<\/p>\n<div id='gallery-1' class='gallery galleryid-2037 gallery-columns-3 gallery-size-large'><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"772\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter-1024x772.png\" class=\"attachment-large size-large\" alt=\"Figure 1 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter-1024x772.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter-300x226.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter-768x579.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter-1536x1158.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig1-chapter.png 1810w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"564\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-1024x564.png\" class=\"attachment-large size-large\" alt=\"Figure 2 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-1024x564.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-300x165.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-768x423.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-1536x846.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig2-chapter-2048x1128.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"811\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-811x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 3 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-811x1024.png 811w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-237x300.png 237w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-768x970.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-1216x1536.png 1216w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig3-chapter-1621x2048.png 1621w\" sizes=\"auto, (max-width: 811px) 100vw, 811px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"755\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-1024x755.png\" class=\"attachment-large size-large\" alt=\"Figure 4 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-1024x755.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-300x221.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-768x566.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-1536x1132.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig4-chapter-2048x1509.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon portrait'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"664\" height=\"1024\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-664x1024.png\" class=\"attachment-large size-large\" alt=\"Figure 5 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-664x1024.png 664w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-195x300.png 195w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-768x1184.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-996x1536.png 996w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter-1328x2048.png 1328w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig5-chapter.png 1868w\" sizes=\"auto, (max-width: 664px) 100vw, 664px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"869\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-1024x869.png\" class=\"attachment-large size-large\" alt=\"Figure 6 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-1024x869.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-300x255.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-768x652.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-1536x1303.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig6-chapter-2048x1738.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"646\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-1024x646.png\" class=\"attachment-large size-large\" alt=\"Figure 7 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-1024x646.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-300x189.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-768x485.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-1536x969.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig7-chapter-2048x1292.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure><figure class='gallery-item'>\n\t\t\t<div class='gallery-icon landscape'>\n\t\t\t\t<a href='https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter.png'><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"680\" src=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-1024x680.png\" class=\"attachment-large size-large\" alt=\"Figure 8 from the book Figure 1 from chapter of book Biophysical Screening for the Discovery of Small-Molecule Ligands\" srcset=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-1024x680.png 1024w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-300x199.png 300w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-768x510.png 768w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-1536x1020.png 1536w, https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-content\/uploads\/sites\/233\/2023\/12\/Fig8-chapter-2048x1360.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/a>\n\t\t\t<\/div><\/figure>\n\t\t<\/div>\n\n","protected":false},"excerpt":{"rendered":"<p>Alessio\u2019s book chapter \u201cBiophysical Screening for the Discovery of Small-Molecule Ligands\u201d is now published in Methods Mol. Biol Read the full chapter.<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[16,4],"tags":[],"class_list":["post-2037","post","type-post","status-publish","format-standard","hentry","category-16","category-news"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=2037"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2037\/revisions"}],"predecessor-version":[{"id":4891,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/posts\/2037\/revisions\/4891"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=2037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/categories?post=2037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/tags?post=2037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}