{"id":2009,"date":"2021-03-17T17:41:00","date_gmt":"2021-03-17T17:41:00","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?p=2009"},"modified":"2026-01-26T15:04:48","modified_gmt":"2026-01-26T15:04:48","slug":"38-million-investment-in-university-spinout-amphista-therapeutics","status":"publish","type":"post","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/2021\/03\/17\/38-million-investment-in-university-spinout-amphista-therapeutics\/","title":{"rendered":"\u00a338 million investment in University spinout Amphista therapeutics"},"content":{"rendered":"
\"Professor<\/figure>\n<\/p>\n

Amphista Therapeutics, a University of Dundee spinout company, has announced a near-\u00a340 million investment that will further its work to develop new drugs for a range of diseases.<\/p>\n

Amphista is a biopharmaceutical company creating first-in-class therapeutics that harness the body\u2019s natural processes to selectively and efficiently degrade and remove disease-causing proteins. The company is a spinout from Professor Alessio Ciulli\u2019s labs at the University\u2019s School of Life Sciences.<\/p>\n

The $53 million (\u00a338 million) Series B financing round is one of the largest investments of this kind to be made in Scotland. The round was co-led by Forbion and Gilde Healthcare, while additional investors include Novartis Venture Fund and Eli Lilly and Company. Amphista has now raised more than \u00a345 million from leading life sciences investment companies and funds.<\/p>\n

The proceeds will be used to accelerate the company\u2019s growing pipeline of potent and selective bifunctional molecules, known as \u2018Amphistas\u2019, to the clinic and to extend its proprietary next-generation targeted protein degradation (TPD) platform. In practice this means that Amphista could produce drugs of the future that will efficiently remove disease-causing proteins from human cells and allow new treatments for a broad range of diseases with high efficacy and reduced potential for drug resistance.<\/p>\n

Professor Ciulli, the scientific founder of Amphista therapeutics, welcomed the investment, saying, \u201cMy lab\u2019s work at Dundee over the last eight years is recognised as world-leading in the field of TPD, which is providing an entirely new way of tackling diseases. As a co-founder of Amphista, I am delighted to have contributed to its growth, and that the commercial potential of our ideas is starting to be validated.<\/p>\n

\u201cThis very substantive financing round by a consortium of outstanding investors shows the originality and quality of Amphista\u2019s assets and workforce. I am very proud of their achievements and look forward to seeing them go from strength to strength. Amphista is on-track to develop first-in-class and best-in-class medicines for unmet medical needs, and it is very exciting to see innovative science translate towards patient benefit.\u201d<\/p>\n

Professor Sir Mike Ferguson, Regius Professor of Life Sciences at Dundee, said, \u201cThe level of investment in Amphista is testament to the quality of the science emerging from the University and a sign of how that can be commercialised in a very exciting way.<\/p>\n

\u201cThe University\u2019s pipeline of new spin-out opportunities is stronger than it has ever been, and we are committed to growing the biomedical industry sector and creating new jobs and opportunities in Dundee and in Scotland. This will be hugely helped by the \u00a325 million Innovation Hub project that we are developing with funding from the Tay Cities Deal.\u201d<\/p>\n

Amphista, based at BioCity in North Lanarkshire, offers the potential to overcome many of the limitations seen with current TPD approaches, providing the opportunity to treat a wider range of diseases. Amphista is focused on biological targets with a high level of clinical or genetic validation, allowing the team to focus on the translation of their novel TPD approach for clinical benefit in areas of high unmet need.<\/p>\n

Amphista CEO Nicola Thompson added, \u201cThis financing round, led by an outstanding investor syndicate, is a strong endorsement of our world class team and our novel approach. Amphista will now accelerate its oncology pipeline towards the clinic and extend our portfolio into indications largely inaccessible by traditional TPD approaches, such as diseases of the central nervous system.<\/p>\n

\u201cThis oversubscribed Series B supports our ambition as a world-leading next generation protein degradation company delivering ground-breaking new medicines to patients in areas of high unmet need.\u201d<\/p>\n

For more information, please visit\u00a0Amphista website<\/a><\/p>\n

Related links<\/h2>\n