{"id":777,"date":"2023-11-16T12:09:56","date_gmt":"2023-11-16T12:09:56","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=777"},"modified":"2026-04-21T12:06:42","modified_gmt":"2026-04-21T11:06:42","slug":"2017-2011","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/publications\/2017-2011\/","title":{"rendered":"2011-2017 Publications"},"content":{"rendered":"<p><strong>Refereed Papers In Primary Journals<\/strong><\/p>\n<p>* A.C. Corresponding Author<\/p>\n<p>\u00a0<\/p>\n<p><strong>64.<\/strong>\u00a0Hughes, S.J., Ciulli, A.*<\/p>\n<p>Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1042\/EBC20170041\"><em>Essays Biochem.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>61<\/em>, 505-516<\/a><\/p>\n<ul>\n<li>Contribution to the journal\u2019s Special Issue\u00a0<a href=\"http:\/\/essays.biochemistry.org\/content\/61\/5\">\u201dStructure-Based Drug Design: Insights from Academia and Industry\u201d<\/a>, Edited by Paul Workman and Rob van Montfort<\/li>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/our-review-molecular-recognition-ternary-complexes-targeted-protein-degradation-now-published\">here<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/practicalfragments.blogspot.co.uk\/2017\/11\/essays-in-biochemistry-special-issue.html\">Practical Fragments<\/a><\/li>\n<li>Check out Darryl McConnell\u2019s video on Structure-Based PROTAC Drug\u00a0Design\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=JNoebLMKAG8\">here<\/a>.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>63.<\/strong>\u00a0Maniaci, C., Hughes, S.J., Testa, A., Chen, W., Lamont, D.J., Rocha, S., Alessi, D.R., Romeo, R., Ciulli, A.*<\/p>\n<p>Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/s41467-017-00954-1\"><em>Nat. Commun.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>8<\/em>, 830<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/x.com\/alessiociulli\/status\/918472336524787712\">here<\/a><\/li>\n<li>Featured in the <a href=\"https:\/\/www.dundee.ac.uk\/stories\/new-small-molecule-tricks-molecular-assassins-destroy-one-another\">UoD<\/a> News websites<\/li>\n<li>Our VHL dimerizer\/degrader\u00a0<a href=\"https:\/\/www.tocris.com\/products\/cm-11_6416\">CM11<\/a>\u00a0and inactive epimer\u00a0<a href=\"https:\/\/www.tocris.com\/products\/cmp-98_6417\">CMP98<\/a>\u00a0are available from Tocris (April 2018)<\/li>\n<li>Find out more about CM11 in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/cm11\">Chemical Probes Portal<\/a><\/li>\n<li>Highlighted as \u201cPromising PROTAC\u201d in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/news\/2020s-top-probes\">2020s Top Probes<\/a>\u00a0list of the Chemical Probes Portal<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>62.<\/strong>\u00a0Morreale, F.E., Testa, A., Chaugule, V.K., Bortoluzzi, A., Ciulli, A.*, Walden, H.*<\/p>\n<p>Mind the metal: a fragment library-derived zinc impurity binds the E2 ubiquitin-conjugating enzyme Ube2T and induces structural rearrangements<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.jmedchem.7b01071\"><em>J. Med. Chem.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>60 (19)<\/em>, 8183-8191<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/mind-zinc-fragment-libraries-our-collaborative-paper-helen-waldens-lab-targeting-e2-ubiquitin\">here<\/a><\/li>\n<li>Access the coordinates of the crystal structure in the Protein DataBank: PDB entry code is\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5OJJ\">5OJJ<\/a><\/li>\n<li>Highlighted in Derek Lowe\u2019s blog\u00a0<a href=\"http:\/\/blogs.sciencemag.org\/pipeline\/archives\/2017\/10\/05\/beware-of-zinc-and-of-other-stuff\">In the Pipeline<\/a><\/li>\n<li>Highlighted in Dan Erlanson\u2019s blog\u00a0<a href=\"http:\/\/practicalfragments.blogspot.co.uk\/2017\/11\/heavy-metals-suck.html\">Practical Fragments<\/a><\/li>\n<li>Listed amongst the\u00a0<a href=\"http:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=jmcmar\">Most Read Articles<\/a>\u00a0in the journal (Oct 2017)<\/li>\n<li>Highlighted in\u00a0<a href=\"https:\/\/sussexdrugdiscovery.wordpress.com\/2018\/02\/09\/2997\/\">Sussex Drug Discovery Centre\u2019s blog<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>61.<\/strong>\u00a0Soares, P., Gadd, M.S., Frost, J., Galdeano, C., Ellis, L.C.J., Epemolu, O., Rocha, S., Read, K.D., Ciulli, A.*<\/p>\n<p>Group-based optimization of potent and cell-active inhibitors of the von Hippel-Lindau (VHL) E3 ubiquitin ligase: structure-activity relationships leading to the chemical probe (2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.7b00675\"><em>J. Med. Chem.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>61 (2)<\/em>, 599-618<\/a><\/p>\n<ul>\n<li>Contribution to the journal\u2019s Special Issue\u00a0<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jmedchem.6b00735\">\u201cInducing Protein Degradation as a Therapeutic Strategy\u201d<\/a><\/li>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/our-paper-disclosing-structure-activity-relationships-leading-potent-vhl-inhibitor-vh298-now\">here<\/a><\/li>\n<li>Access the coordinates of our co-crystal structures in the Protein DataBank: PDB entry codes are\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NVV\">5NVV<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NVW\">5NVW<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NVX\">5NVX<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NVY\">5NVY<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NVZ\">5NVZ<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NW0\">5NW0<\/a>,\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NW1\">5NW1<\/a>, and\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5NW2\">5NW2<\/a><\/li>\n<li>8th\u00a0<a href=\"http:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Most Read Article<\/a>\u00a0in the journal (Sept 2017)<\/li>\n<li>Our VHL ligand VH032-amide and its inactive epimer cis-VH032, as well as various functionalized versions e.g. VHL-ligand plus linkers are available from\u00a0<a href=\"https:\/\/www.tocris.com\/product-type\/degrader-building-blocks\">Tocris<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>60.<\/strong>\u00a0Khan, R., Marsh, G., Felix, R., Kemmitt, P.D., Baud, M.G.J., Ciulli, A., Spencer, J.<\/p>\n<p>Gram-Scale\u00a0Laboratory Synthesis of TC AC 28, a High-Affinity BET Bromodomain Ligand<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acsomega.7b00780\"><em>ACS Omega<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>2 (8)<\/em>, 4328\u20134332<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>59.<\/strong>\u00a0Cardote, T.A.F., Ciulli, A.*<\/p>\n<p>Structure-guided design of peptides as tools to probe the protein-protein interaction between Cullin-2 and Elongin BC substrate adaptor in Cullin RING E3 ubiquitin ligases<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1002\/cmdc.201700359\"><em>ChemMedChem<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>12 (18)<\/em>, 1491-1496<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/new-paper-structure-guided-design-peptides-targeting-protein-protein-interaction-between-cullin\">here<\/a><\/li>\n<li>2nd\u00a0<a href=\"http:\/\/onlinelibrary.wiley.com\/journal\/10.1002\/(ISSN)1860-7187\/homepage\/2452_mostaccessed.html\">Most Accessed Article<\/a>\u00a0in ChemMedChem (Sept 2017)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>58.<\/strong>\u00a0Chan, K.-H., Zengerle, M., Testa, A., Ciulli, A.*<\/p>\n<p>Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.jmedchem.6b01912\"><em>J. Med. Chem.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>61 (2)<\/em>, 504-513<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/our-paper-studying-effect-linking-mechanism-action-bet-degraders-now-published-j-med-chem\">here<\/a><\/li>\n<li>Contribution to the 2017 journal\u2019s Special Issue on\u00a0<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jmedchem.6b00735\">\u201cInducing Protein Degradation as a Therapeutic Strategy\u201d<\/a><\/li>\n<li>Find out more about our I-BET726-based PROTAC MZP-54 in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/mzp-54\">Chemical Probes Portal<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>57.<\/strong>\u00a0Cardote, T.A.F., Gadd, M.S., Ciulli, A.*<\/p>\n<p>Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.str.2017.04.009\"><em>Structure<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>25 (6)<\/em>, 901-911.e3<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/our-paper-reporting-first-crystal-structure-vhl-elobc-cul2-rbx1-multi-subunit-complex-now\">here<\/a><\/li>\n<li>Featured in the\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/news\/2017\/jun\/6\/phd-student-teresa-cardote-solves-first-crystal-structure-cullin-2-ring-ligase\">SLS News website<\/a><\/li>\n<li>Access the coordinates of our pentameric complex crystal structure in the Protein DataBank: PDB entry code is\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5N4W\">5N4W<\/a><\/li>\n<li>pIVM_02 (<a href=\"https:\/\/www.addgene.org\/204500\/\">Plasmid #204500<\/a>) is now available on Addgene. This is an expression plasmid of 6xHis-VHL (54-213) for production of VCB complexes in conjunction with plasmid pIVM_26 (EloB 1-104, EloC 17-112).<\/li>\n<li>pIVM_26 (<a href=\"https:\/\/www.addgene.org\/204501\/\">Plasmid #204501<\/a>) is now available on Addgene. This is a pCDF-1b DUET expression plasmid of EloB (1-104) and EloC (17-112) (both untagged) for production of VCB complexes in conjunction with plasmid pIVM_02 (VHL 54-213) or other BC-box containing proteins.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>56.<\/strong>\u00a0Fernandez-Alonso, R., Davidson, L., Hukelmann, J., Zengerle, M., Prescott, A.R., Lamond, A., Ciulli, A., Sapkota, G.P., Findlay, G.M.<\/p>\n<p>Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.15252\/embr.201643534\"><em>EMBO Reports<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>18 (7)<\/em>, 1108-1122<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>55.<\/strong>\u00a0Morreale, F.E., Bortoluzzi, A., Chaugule, V.K., Arkinson, C., Walden, H.*, Ciulli, A.*<\/p>\n<p>Allosteric targeting of the Fanconi anemia ubiquitin-conjugating enzyme Ube2T by fragment screening<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1021\/acs.jmedchem.7b00147\"><em>J. Med. Chem.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>60 (9)<\/em>, 4093-4098<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>54.<\/strong>\u00a0Ryan, A., Polycarpou, E., Lack, N.A., Evangelopoulos, D., Sieg, C., Halman, A., Bhakta, S., Eleftheriadou, O., McHugh, T.D., Keany, S., Lowe, E.D., Ballet, R., Abuhammad, A., Jacobs, W.R. Jr, Ciulli, A., Sim, E.<\/p>\n<p>Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1111\/bph.13810\"><em>Br. J. Pharmacol.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>174 (14)<\/em>, 2209-2224<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>53.<\/strong>\u00a0Bortoluzzi, A., Amato, A., Lucas, X., Blank, M., Ciulli, A.*<\/p>\n<p>Structural Basis of Molecular Recognition of Helical Histone H3 Tail by PHD Finger Domains<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1042\/BCJ20161053\"><em>Biochem. J.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>474 (10)<\/em>, 1633-1651<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2017\/03\/23\/molecular-recognition-of-helical-histone-tail-by-phd-finger-domains\/\">here<\/a><\/li>\n<li>Access the coordinates of our domain-peptide complex crystal structure in the Protein Data Bank: PDB entry code is\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5T8R\">5T8R<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>52.<\/strong>\u00a0Gadd, M.S., Testa, A., Lucas, X., Chan, K.-H., Chen, W., Lamont, D.J., Zengerle, M., Ciulli, A.*<\/p>\n<p>Structural basis of PROTAC cooperative recognition for selective protein degradation<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/nchembio.2329\"><em>Nat. Chem. Biol.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>13 (5)<\/em>, 514-521<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2017\/03\/13\/first-ternary-crystal-structure-of-a-protac-bound-to-to-its-e3-ligase-vhl-and-brd4-target\/\">here<\/a><\/li>\n<li>Read the article open access\u00a0<a href=\"http:\/\/rdcu.be\/p2RH\">here<\/a>; EuropePMC article\u00a0<a href=\"http:\/\/europepmc.org\/abstract\/MED\/28288108\">here<\/a><\/li>\n<li>Top\u00a0<a href=\"http:\/\/www.nature.com\/nchembio\/index.html#most-read\">\u201cMost Read\u201d<\/a>\u00a0article within a week of appearing online in the journal (19 March 2017)<\/li>\n<li>Top\u00a0<a href=\"http:\/\/www.nature.com\/nchembio\/index.html#trending\">\u201cTrending Online\u201d<\/a>\u00a0article within 4 days of appearing online (17 March 2017)<\/li>\n<li>Featured in the\u00a0<a href=\"https:\/\/app.dundee.ac.uk\/news\/2017\/a-kiss-of-death-to-drug-the-undruggable.php\">UoD<\/a> News websites<\/li>\n<li>Featured in\u00a0<a href=\"http:\/\/www.fiercebiotech.com\/research\/using-a-kiss-death-to-neutralize-disease-causing-proteins\">FierceBiotech<\/a>,\u00a0<a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2017-03\/uod-ako031017.php\">EurekAlert<\/a>, and\u00a0<a href=\"https:\/\/www.sciencedaily.com\/releases\/2017\/03\/170313135028.htm\">ScienceDaily<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/globalnews.ca\/news\/3309344\/scientist-discover-kiss-of-death-for-cancer-causing-proteins\/\">GlobalNews<\/a>,\u00a0<a href=\"http:\/\/www.dailymail.co.uk\/health\/article-4310716\/Cancer-breakthrough-Scientists-kill-undruggable-protein.html?ITO=1490&amp;ns_mchannel=rss&amp;ns_campaign=1490\">MailOnline<\/a>,\u00a0<a href=\"http:\/\/www.express.co.uk\/news\/uk\/778766\/Scientists-discover-kiss-of-death-technique-to-destroy-cancer-disease?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A%20daily-express-uk-news%20%28Express%20%3A%3A%20UK%20Feed%29\">SundayExpress<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.thesun.co.uk\/living\/3080130\/cancer-could-be-wiped-out-after-scientists-discover-how-to-destroy-key-proteins-thought-to-be-untouchable\/\">The Sun<\/a><\/li>\n<li>Access the coordinates of our ternary crystal structure in the Protein DataBank: PDB entry code is\u00a0<a href=\"http:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5T35\">5T35<\/a><\/li>\n<li>Highlighted three times in the Faculty of 1000 Prime.\u00a0<a href=\"http:\/\/f1000.com\/prime\/727397475?bd=1\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" id=\"bg\" src=\"https:\/\/cdn.f1000.com.s3.amazonaws.com\/images\/badges\/badgef1000.gif\" alt=\"Access the recommendation on F1000Prime\"><\/a><\/li>\n<li>Featured in a News &amp; Views article by Nico Thoma and colleagues in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1038\/nchembio.2355\">Nature Chemical Biology<\/a><\/li>\n<li>Find out more about AT1 in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/at1\">Chemical Probes Portal<\/a><\/li>\n<li>Our Brd4-selective degrader AT1 is available from\u00a0<a href=\"https:\/\/www.tocris.com\/products\/at-1_6356\">Tocris<\/a>\u00a0(from February 2018)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p>(<strong>51.<\/strong> Bortoluzzi &amp; Ciulli <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/book-chapters-and-patents\/\">book chapter<\/a>)<\/p>\n<p>\u00a0<\/p>\n<p><strong>50.<\/strong>\u00a0De Schutter, J.W., Morrison, J.P., Morrison, M.J., Ciulli, A., Imperiali, B.<\/p>\n<p>Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from\u00a0<em>Campylobacter jejuni<\/em><\/p>\n<p><a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acs.jmedchem.6b01869\"><em>J. Med. Chem.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>60 (5)<\/em>, 2099-2118<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>49.<\/strong>\u00a0Lucas, X., Ciulli, A.*<\/p>\n<p>Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.sbi.2016.12.015\"><em>Curr. Opin. Struct. Biol.<\/em>\u00a0<strong>2017<\/strong>,\u00a0<em>44<\/em>, 101-110<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2017\/01\/25\/recognition-and-small-molecule-mimicry-of-degrons-by-e3-ligases\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>48.<\/strong>\u00a0Frost, J., Galdeano, C., Soares, P., Gadd, M.S., Epemolu, O., Grzes, K., Ellis, L., Shimamura, S., Bantscheff, M., Grandi, P., Read, K.D., Cantrell, D.A., Rocha, S., Ciulli, A.*<\/p>\n<p>Potent and selective chemical probe of hypoxic signalling downstream of HIF-\u03b1\u00a0hydroxylation via VHL inhibition<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/ncomms13312\"><em>Nat. Commun.<\/em>\u00a0<strong>2016<\/strong>,\u00a0<em>7<\/em>, 13312<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2016\/11\/04\/vhl-inhibitor-vh298-as-novel-chemical-probe-of-the-hypoxia-signalling-pathway\/\">here<\/a><\/li>\n<li>Featured in the\u00a0<a href=\"https:\/\/app.dundee.ac.uk\/news\/2016\/molecular-commando-identified-to-tackle-hypoxia-pathway.php\">UoD<\/a> News websites<\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/www.drugdiscoverytoday.com\/view\/45004\/molecular-commando-identified-to-tackle-hypoxia-pathway\/\">Drug Discovery Today<\/a>\u00a0and\u00a0<a href=\"https:\/\/phys.org\/news\/2016-11-molecular-commando-tackle-hypoxia-pathway.html\">Phys.org<\/a><\/li>\n<li>Access the coordinates of our protein-ligand co-crystal structure in the Protein DataBank: PDB entry code is\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/explore\/explore.do?structureId=5LLI\">5LLI<\/a><\/li>\n<li>FInd out more about VH298 in the\u00a0<a href=\"http:\/\/www.chemicalprobes.org\/vh298\">Chemical Probes Portal<\/a><\/li>\n<li>Our VHL inhibitor VH298 and inactive epimer cis-VH298 are available from\u00a0<a href=\"https:\/\/www.tocris.com\/dispprod.php?ItemId=525614#.WQY9NFMrI0p\">Tocris<\/a>\u00a0(from April 2017)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>47.<\/strong>\u00a0Ciulli, A.*<\/p>\n<p>Target validation: Switching domains<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/nchembio.2154\"><em>Nat. Chem. Biol.<\/em>\u00a0<strong>2016<\/strong>,\u00a0<em>12 (9)<\/em>, 659-660<\/a><\/p>\n<ul>\n<li>See Figure\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2016\/08\/18\/target-validation-switching-domains\/\">here<\/a><\/li>\n<li>News &amp; Views article on\u00a0<a href=\"https:\/\/doi.org\/10.1038\/nchembio.2115\">Hohmann et al.\u00a0<em>Nat. Chem. Biol.<\/em>\u00a0<em>12<\/em>, 672\u2013679 (<strong>2016<\/strong>)<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>46.<\/strong>\u00a0Runcie, A.C., Chan, K.-H., Zengerle, M., Ciulli, A.*<\/p>\n<p>Chemical genetics approaches for selective intervention in epigenetics<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.cbpa.2016.06.031\"><em>Curr. Opin. Chem. Biol.<\/em>\u00a0<strong>2016<\/strong>,\u00a0<em>33<\/em>, 186-194<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2016\/07\/13\/advanced-chemical-genetics-for-epigenetics\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>45.<\/strong>\u00a0Galdeano, C., Ciulli, A.*<\/p>\n<p>Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.4155\/fmc-2016-0059\"><em>Future Med. Chem.<\/em>\u00a0<strong>2016<\/strong>,\u00a0<em>8 (13)<\/em>, 1655-1680<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2016\/05\/19\/selectivity-of-chemical-probes-targeting-bromodomains\/\">here<\/a><\/li>\n<li>Top\u00a0<a href=\"https:\/\/www.future-science.com\/journal\/fmc\">Most Read Paper<\/a>\u00a0in Future Med. Chem.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>44.<\/strong> Dias, D.M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T.Q., Baaske, P., Brito, R.M., Ciulli, A., Sim\u00f5es, I., MacEdo-Ribeiro, S., Faro, C., Geraldes, C.F., Castanheira, P.<\/p>\n<p>Biophysical characterization of laforin-carbohydrate interaction<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1042\/bj20141555\"><em>Biochem. J.<\/em> <strong>2016<\/strong> Feb 1;<em>473(3)<\/em>:335-45.<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26578817\/\">26578817<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>43.<\/strong> Cardote, T.A.F., Ciulli, A.<strong>*<\/strong><\/p>\n<p>Cyclic and macrocyclic peptides as chemical tools to recognise protein surfaces and probe protein-protein interactions<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1002\/cmdc.201500450\"><em>ChemMedChem<\/em> <strong>2016<\/strong> Apr 19;<em>11(8)<\/em>:787-94.<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26563831\/\">26563831<\/a><\/li>\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2015\/11\/13\/cyclic-and-macrocyclic-peptides-as-chemical-tools-to-probe-ppis\/\">here<\/a><\/li>\n<li>Paper announced 5<sup>th<\/sup> most accessed article in ChemMedChem (Feb 2016)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>42.<\/strong> Baud, M.G.J., Lin-Shiao, E., Zengerle, M., Tallant, C., Ciulli A.<strong>*<\/strong><\/p>\n<p>New synthetic routes to triazolo-benzodiazepine analogues: expanding the scope of the bump-and-hole approach for selective BET bromodomain inhibition<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5b01135\"><em>J. Med. Chem.<\/em> <strong>2016 <\/strong>Feb 25;<em>59(4)<\/em>:1492-500<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/26367539\/\">26367539<\/a><\/li>\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2015\/09\/15\/triazolo-benzodiazepine-chemistry-to-i-bet-jq1-analogues-for-the-bump-and-hole-approach-and-bd2-selectivity\/\">here<\/a><\/li>\n<li>Paper announced 13<sup>th<\/sup> most read J. Med. Chem. article (1 month framework, Nov 2015)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>41.<\/strong>\u00a0Gadd, M.S., Bulatov, E., Ciulli, A.*<\/p>\n<p>Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pone.0131218\"><em>PLoS ONE<\/em>\u00a0June 29,\u00a0<strong>2015<\/strong>; 10(6):e013218<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2015\/06\/29\/crystallography-of-socs2-elob-eloc-complex-by-arsenic-sad\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>40. <\/strong>Zengerle, M., Chan, K.-H., Ciulli, A.*<\/p>\n<p>Selective small molecules induced degradation of the BET bromodomain protein BRD4<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acschembio.5b00216\"><em>ACS Chem. Biol.<\/em>\u00a0<strong>2015<\/strong>,\u00a0<em>10 (8)<\/em>, 1770-1777<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2015\/07\/06\/brd4-intra-bet-selective-chemical-degraders-hijacking-the-vhl-e3-ubiquitin-ligase\/\">here<\/a><\/li>\n<li>Featured in the\u00a0<a href=\"https:\/\/app.dundee.ac.uk\/news\/2015\/a-super-targeted-method-of-destroying-tumour-proteins.php\">UoD<\/a> News websites<\/li>\n<li>Featured in\u00a0<a href=\"http:\/\/www.bbc.co.uk\/news\/uk-scotland-tayside-central-33137701\">BBC News<\/a><\/li>\n<li>Listed amongst\u00a0<a href=\"http:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=recent&amp;journalCode=acbcct\">Most Read Articles<\/a>\u00a0in ACS Chem. Biol. (1 and 12 months frameworks)<\/li>\n<li>Find out more about MZ1 in the\u00a0<a href=\"http:\/\/www.chemicalprobes.org\/mz1\">Chemical Probes Portal<\/a><\/li>\n<li>Our Brd4 degrader PROTAC MZ1 and the inactive epimer cis-MZ1 are available from\u00a0<a href=\"https:\/\/www.tocris.com\/dispprod.php?ItemId=525612#.WQY8sVMrI0p\">Tocris<\/a>\u00a0(from April 2017)<\/li>\n<li><a href=\"http:\/\/opnme.com\/molecules\/bet-mz-1\">MZ1<\/a>\u00a0(and cis-MZ1) are available from Boehringer Ingelheim\u2019s\u00a0<a href=\"http:\/\/opnme.com\/molecules\/bet-mz-1\">OpnMe Portal<\/a>: order for free, no strings attached!<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>39. <\/strong>Bulatov, E., Ciulli, A.*<\/p>\n<p>Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: Structure, assembly and small molecule modulation<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1042\/BJ20141450\"><em>Biochem. J.<\/em>\u00a0<strong>2015<\/strong>,\u00a0<em>467 (3)<\/em>, 365-386<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2015\/04\/17\/structure-protein-protein-interactions-and-drug-discovery-targeting-cullin-ring-e3-ubiquitin-ligases\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>38. <\/strong>Tallant, C., Valentini, E. Fedorov, O., Overvoorde, L., Ferguson, F.M., Filippakopoulos, P., Svergun, D.I., Knapp, S., Ciulli, A.*<\/p>\n<p>Molecular basis of histone tail recognition by human TIP5 PHD finger and Bromodomain of the chromatin remodelling complex NoRC<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.str.2014.10.017\"><em>Structure<\/em>\u00a0<strong>2015<\/strong>,\u00a0<em>23 (1)<\/em>, 80-92<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/12\/18\/structural-basis-of-histone-tail-recognition-by-human-baz2a-tip5-and-baz2b-epigenetic-reader-domains-phd-finger-and-bromodomain\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>37.<\/strong>\u00a0Bulatov, E., Martin, E.M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F., Ciulli, A.*<\/p>\n<p>Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2):ElonginBC:Cullin5:RING-box protein 2 (Rbx2)<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1074\/jbc.M114.616664\"><em>J. Biol. Chem.<\/em>\u00a0<strong>2015<\/strong>,\u00a0<em>290 (7)<\/em>, 4178-4191<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/11\/12\/biophysical-investigation-of-interactions-and-assembly-of-full-size-socs2elobccul5rbx2-e3-ubiquitin-ligase\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>36.<\/strong>\u00a0Baud, M.G., Lin-Shiao, E., Cardote, T., Tallant, C., Pschibul, A., Chan, K.H., Zengerle, M., Garcia, J.R., Kwan, T.T., Ferguson, F.M., Ciulli, A.*<\/p>\n<p>A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1126\/science.1249830\"><em>Science<\/em>\u00a0<strong>2014<\/strong>,\u00a0<em>346 (6209)<\/em>, 638-641<\/a><\/p>\n<ul>\n<li>Read the paper Open Access in Europe PubMed Central\u00a0<a href=\"http:\/\/europepmc.org\/articles\/PMC4458378\">here<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/10\/16\/chemical-genetics-bump-and-hole-approach-to-engineer-controlled-selectivity-of-bet-bromodomain-inhibitors\/\">here<\/a><\/li>\n<li>Featured in the\u00a0<a href=\"http:\/\/www.bbsrc.ac.uk\/news\/health\/2014\/141020-pr-bump-and-hole-brings-protein-breakthrough.aspx\">BBSRC<\/a>\u00a0and\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/news\/2014\/oct\/22\/ciulli-labs-bump-and-hole-approach-leads-protein-breakthrough\">Dundee CLS<\/a>\u00a0News websites<\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1158\/2159-8290.CD-RW2014-222\">Cancer Discovery<\/a>\u00a0Research Watch<\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/www.nature.com\/nchembio\/journal\/v10\/n12\/full\/nchembio.1706.html\">Nature Chemical Biology<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1038\/nmeth.3246\">Nature Methods<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>35.<\/strong>\u00a0Ferguson, F.M., Dias, D.M., Rodrigues, J.P., Wienk, H., Boelens, R., Bonvin, A.M., Abell C., Ciulli A.*<\/p>\n<p>Binding Hotspots of BAZ2B Bromodomain: Histone Interaction Revealed by Solution NMR Driven Docking<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/bi500909d\"><em>Biochemistry<\/em><strong>\u00a02014<\/strong>,\u00a0<em>53 (42)<\/em>, 6706-6716<\/a><\/p>\n<ul>\n<li>\u00a0See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/09\/30\/elucidating-binding-hotspots-of-the-baz2b-bromodomainhistone-interaction\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>34.<\/strong>\u00a0Galdeano, C., Gadd, M.S., Soares, P., Scaffidi, S., Van Molle, I., Birced, I., Hewitt, S., Dias, D.M., Ciulli A.*<\/p>\n<p>Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with In Vitro Nanomolar Affinities<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/jm5011258\"><em>J<\/em><em>. Med. Chem.<\/em>\u00a0<strong>2014<\/strong>,\u00a0<em>57 (20)<\/em>, 8657-8663<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/08\/28\/structure-guided-optimization-of-nanomolar-inhibitors-of-the-vhl-hifalpha-protein-protein-interaction\/\">here<\/a><\/li>\n<li><a href=\"http:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Top Most Read Article<\/a>\u00a0in the journal (12 months timeframe)<\/li>\n<li>Our VHL ligand VH032-amide and its inactive epimer cis-VH032, as well as various functionalized versions e.g. VHL-ligand plus linkers are available from\u00a0<a href=\"https:\/\/www.tocris.com\/product-type\/degrader-building-blocks\">Tocris<\/a><\/li>\n<li>Access the coordinates of our VHL-liganded co-crystal structures in the Protein DataBank: PDB entry codes are\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9C\">4W9C<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9D\">4W9D<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9E\">4W9E<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9F\">4W9F<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9G\">4W9G<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9H\">4W9H<\/a>\u00a0(VHL bound to ligand 7, aka VH032),\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9I\">4W9I<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9J\">4W9J<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9K\">4W9K<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/4W9L\">4W9L<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>33.<\/strong>\u00a0Dias, D.M., Ciulli, A.*<\/p>\n<p>NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.pbiomolbio.2014.08.012\"><em>Prog. Biophys. Mol. Biol.<\/em>\u00a0<strong>2014<\/strong>,\u00a0<em>116 (2-3)<\/em>, 101-112<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2014\/08\/27\/nmr-approaches-in-structure-based-lead-discovery-for-targeting-multi-protein-complexes\/\">here<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/practicalfragments.blogspot.co.uk\/2014\/12\/progress-in-biophysics-and-molecular.html\">Practical Fragments<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>32.<\/strong> Dias, D.M., Van Molle, I., Baud, M.G.J., Galdeano, C., Geraldes, C.F.G.C., Ciulli, A.*<\/p>\n<p>Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein-Protein Interactions?<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/ml400296c\"><em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>2014<\/strong>,\u00a0<em>5 (1)<\/em>, 23-28<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2013\/03\/11\/our-paper-interrogating-the-nmr-binding-detection-limits-of-fragments-targeting-the-vhl-hif1%ce%b1-ppi\/\">here<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/practicalfragments.blogspot.co.uk\/2014\/02\/how-weak-is-too-weak-for-ppis.html\">Practical Fragments<\/a><\/li>\n<li>4th Most-Read Article in ACS Med. Chem. Lett. (Nov-Dec 2013)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>31<\/strong>. Ferguson, F.M., Fedorov, O., Chaikuad, A., Philpott, M., Muniz, J., Felletar, I., von Delft, F., Heightman, T.D., Knapp, S., Abell, C., Ciulli, A.*<\/p>\n<p>Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design Against the BAZ2B Bromodomain<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/jm401582c\"><em>J. Med. Chem.\u00a0<\/em><strong>2013<\/strong>,\u00a0<em>56 (24)<\/em>, 10183-10187<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2013\/12\/04\/targeting-the-low-druggability-baz2b-bromodomain-using-fragment-based-drug-design\/\">here<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/practicalfragments.blogspot.it\/2013\/12\/bromodomains-as-well-as-other.html\">Practical Fragments<\/a><\/li>\n<li>6th Most-Read\u00a0Article in the journal (Dec-Jan 2014)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>30.<\/strong> Thomas, J.C., Matak-Vinkovic, D., Van Molle, I., Ciulli, A.*<\/p>\n<p>Multimeric Complexes among Ankyrin-Repeat and SOCS-box Protein 9 (ASB9), ElonginBC, and Cullin 5: Insights into the Structure and Assembly of ECS-type Cullin-RING E3 Ubiquitin Ligases<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/bi400758h\"><em>Biochemistry\u00a0<\/em><strong>2013<\/strong><em>, 52 (31),\u00a0<\/em>5236-5246<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2013\/07\/22\/affinity-and-structural-assembly-of-the-asb9-crl\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>29<\/strong>. Van Molle, I., Thomann, A., Buckley, D.L., So, E.C., Lang, S., Crews, C.M., Ciulli, A.*<\/p>\n<p>Dissecting Fragment-Based Lead Discovery at the von-Hippel Lindau Protein : Hypoxia Inducible Factor 1\u03b1\u00a0Protein-Protein Interface<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.chembiol.2012.08.015\"><em>Chem. Biol.<\/em>\u00a0<strong>2012<\/strong>,\u00a0<em>19<\/em>, 1300-1312<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>28<\/strong>. Buckley, D.L., Gustafson, J.L., Van Molle, I., Roth, A.G., Tae, H.S., Gareiss, P.C., Jorgensen, W.L., Ciulli, A., Crews, C.M.<\/p>\n<p>Small Molecules Inhibitors of the Interaction Between the E3 Ligase VHL and HIF1\u03b1<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1002\/anie.201206231\"><em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2012<\/strong>,\u00a0<em>51<\/em>, 11463-11467<\/a><\/p>\n<ul>\n<li>Selected as a \u201cHot paper\u201d by the Editors of\u00a0<em>Angew. Chem.<\/em>\u00a0and\u00a0<em>Angew. Chem. Int. Ed.<\/em><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>27<\/strong>. Buckley, D.L., Van Molle, I., Gareiss, P.C., Tae, H.S., Michel, J., Noblin, D.J., Jorgensen, W.L., Ciulli, A.,* Crews, C.M.*<\/p>\n<p>Targeting the von Hippel-Lindau E3 Ubiquitin Ligase Using Small Molecules to Disrupt the VHL\/HIF-1\u03b1\u00a0Interaction<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/ja209924v\"><em>J. Am. Chem. Soc.<\/em>\u00a0<strong>2012<\/strong>,\u00a0<em>134<\/em>, 4465\u20134468<\/a><\/p>\n<ul>\n<li>Highlighted in\u00a0<a href=\"http:\/\/ppi-net.org\/interesting-publications\">PPI-Net.org<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1038\/scibx.2012.514\">Lou, K.-J. SciBX 5(20)<\/a><\/li>\n<li>The fluorescent FAM-labeled 10-mer HIF-1\u03b1 peptide (<a href=\"https:\/\/www.tocris.com\/products\/fam-deala-hyp-yipd_7287\">FAM-DALA-Hyp-YIPD<\/a>) first used in this paper to develop a VHL-HIF displacement FP assay is now available on Tocris (October 2020)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>26<\/strong>. Philpott, M., Yang, J., Tumber, T., Fedorov, O., Uttarkar, S., Filippakopoulos, P., Picaud, S., Keates, T., Felletar, I., Ciulli, A., Knapp, S., Heightman, T.D.<\/p>\n<p>Bromodomain-peptide displacement assays for interactome mapping and inhibitor discovery<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1039\/C1MB05099K\"><em>Mol. Biosyst.<\/em>\u00a0<strong>2011<\/strong>,\u00a0<em>7<\/em>, 2899\u20132908<\/a><\/p>\n<ul>\n<li>Top Most-Accessed Article in August 2011<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Refereed Papers In Primary Journals * A.C. Corresponding Author \u00a0 64.\u00a0Hughes, S.J., Ciulli, A.* Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders Essays Biochem.\u00a02017,\u00a061, 505-516 Contribution to the journal\u2019s Special Issue\u00a0\u201dStructure-Based Drug Design: Insights from Academia and Industry\u201d, Edited by Paul Workman and Rob van Montfort See Figures\u00a0here [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":168,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-777","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/777","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=777"}],"version-history":[{"count":2,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/777\/revisions"}],"predecessor-version":[{"id":5064,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/777\/revisions\/5064"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}