{"id":774,"date":"2023-11-16T12:07:22","date_gmt":"2023-11-16T12:07:22","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=774"},"modified":"2026-01-26T14:20:02","modified_gmt":"2026-01-26T14:20:02","slug":"book-chapters-and-patents","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/publications\/book-chapters-and-patents\/","title":{"rendered":"Book chapters and patents"},"content":{"rendered":"<h2>Book Chapters<\/h2>\n<p>\u00a0<\/p>\n<p><strong>126.<\/strong>\u00a0Ramachandran, S., Szewczyk, M., Barghout, S.H., Ciulli, A., Barsyte-Lovejoy, D., Vu, V.<\/p>\n<p>HiBiT Cellular Thermal Shift Assay (HiBiT CETSA).<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1007\/978-1-0716-3397-7_11\"><em>Methods Mol. Biol.<\/em>\u00a0<strong>2023<\/strong>, vol. 2706, pp. 149-165<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37558947\/\">37558947<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>121.<\/strong>\u00a0Ciulli, A.,* Hsia, O.<\/p>\n<p>PROTAC Degraders: Mechanism, Recent Advances, and Future Challenges, In:\u00a0\u2018Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective\u2019<\/p>\n<p>M. Kostic and L. H. Jones, Ed., John Wiley &amp; Sons. 2023, pp. 317-356. ISBN: 978-1-119-77418-1<\/p>\n<p>DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1002\/9781119774198.ch9\">10.1002\/9781119774198.ch9<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>101.<\/strong>\u00a0Bartoschik, T., Zoephel, A., Rumpel, K., Ciulli, A., Heffern, C.<\/p>\n<p>MST and TRIC Technology to Reliably Study PROTAC Binary and Ternary Binding in Drug Development,\u00a0In: \u2018Targeted Protein Degradation\u2019. Methods in Molecular Biology, vol 2365.<\/p>\n<p>Cacace A.M., Hickey C.M., B\u00e9k\u00e9s M. (eds)\u00a0Humana, New York, NY,\u00a0<strong>2021<\/strong>. ISBN:\u00a0978-1-0716-1664-2<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1007\/978-1-0716-1665-9_6\"><em>Methods Mol Biol.<\/em>\u00a0<strong>2021<\/strong>, vol. 2365, pp. 115-133<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34432241\/\">34432241<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>100.<\/strong>\u00a0Casement R., Bond A., Craigon C., Ciulli A.*<\/p>\n<p>Mechanistic and Structural Features of PROTAC Ternary Complexes,\u00a0In: \u2018Targeted Protein Degradation\u2019. Methods in Molecular Biology, vol 2365.<\/p>\n<p>Cacace A.M., Hickey C.M., B\u00e9k\u00e9s M. (eds)\u00a0Humana, New York, NY,\u00a0<strong>2021<\/strong>. ISBN:\u00a0978-1-0716-1664-2<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1007\/978-1-0716-1665-9_5\"><em>Methods Mol Biol.<\/em>\u00a0<strong>2021<\/strong>, vol. 2365, pp. 79-113<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34432240\/\">34432240 <\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>84<\/strong>. Zollman, D., Ciulli, A.*<\/p>\n<p>Structural and Biophysical Principles of Degrader Ternary Complexes, in: \u2018Protein Degradation with New Chemical Modalities: Successful Strategies in Drug Discovery and Chemical Biology\u2019.<\/p>\n<p>H. Weinmann and C. Crews, Ed., Royal Society of Chemistry, Cambridge, UK,\u00a0<strong>2020<\/strong>, pp. 14\u201354. ISBN: 978-1-78801-686-5<\/p>\n<p>DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1039\/9781839160691-00014\">10.1039\/9781839160691-00014<\/a><\/p>\n<ul>\n<li>See figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/10\/08\/our-chapter-on-structural-biophysical-principles-of-degraders-ternary-complexes-is-now-published-in-the-new-rsc-book-protein-degradation-with-new-chemical-modalities\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>51<\/strong>. Bortoluzzi, A., Ciulli, A.*<\/p>\n<p>Protein-Based NMR Methods Applied to Drug Discovery, in: \u2018Applied Biophysics in Drug Discovery\u2019.<\/p>\n<p>D. Huddler and E. R. Zartler, Ed., John Wiley &amp; Sons.\u00a0<strong>2017<\/strong>, pp. 153-173. ISBN: 978-1-119-09948-2<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1002\/9781119099512.ch9\">DOI: 10.1002\/9781119099512.ch9<\/a><\/p>\n<ul>\n<li>Book highlighted in\u00a0<a href=\"http:\/\/practicalfragments.blogspot.co.uk\/2017\/10\/on-par-with-pyramids-new-book-on-drug.html\">Practical Fragments<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>23.<\/strong>\u00a0Ciulli, A.*<\/p>\n<p>Biophysical Screening for the Discovery of Small-Molecule Ligands, in: \u2018Protein-Ligand Interactions \u2013 Methods and Applications, 2nd Ed.\u2019.<\/p>\n<p>T. Daviter and M. Williams, Ed., Springer Protocols, Humana Press,\u00a0<strong>2013<\/strong>. ISBN: 978-1-62703-397-8<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1007\/978-1-62703-398-5_13\"><em>Methods Mol Biol.<\/em>\u00a0<strong>2013<\/strong>, vol. 1008, pp. 357-388<\/a><\/p>\n<ul>\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/23729259\/\">23729259<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2013\/12\/06\/biophysical-screening-for-the-discovery-of-small-molecule-ligands\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>21<\/strong>. \u015aled\u017a, P., Abell, C., Ciulli, A.*<\/p>\n<p>Ligand\u2010Observed NMR in Fragment\u2010Based Approaches, in: \u2018NMR of Biomolecules: Towards Mechanistic Systems Biology\u2019.<\/p>\n<p>I. Bertini, K. McGreevy and G. Parigi, Ed., Wiley,\u00a0<strong>2012<\/strong>, pp. 265\u2013280. ISBN: 978-3-527-32850-5<\/p>\n<p>DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1002\/9783527644506.ch15\">10.1002\/9783527644506.ch15<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>17<\/strong>. Heikkila, T.J., Surade, S., Silvestre, H.L., Dias, M.V., Ciulli, A., Bromfield, K.M., Scott, D.E., Howard, N.I, Wen, S., Wei, A.H., Osborne, D.M., Abell, C., Blundell, T.L.<\/p>\n<p>Fragment-based drug discovery in academia: Experiences from a tuberculosis programme, in: Proceedings of the NATO International School of Crystallography, 40th Course \u2018From Molecules to Medicine: Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism\u2019.<\/p>\n<p>J. L. Sussman and P. Spadon, Ed., Springer,\u00a0<strong>2009<\/strong>, pp. 21\u201336. ISBN: 978-9-048-12338-4<\/p>\n<p>DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1007\/978-90-481-2339-1_3\">10.1007\/978-90-481-2339-1_3<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>14<\/strong>.\u00a0Ciulli, A., Blundell, T.L., Abell, C.<\/p>\n<p>Discovery and extrapolation of fragment structures towards drug design, in: \u2018Computational and Structural Approaches to Drug Discovery \u2013 Ligand-Protein Interactions\u2019.<\/p>\n<p>R. M. Stroud and J. Finer-Moore, Ed., Royal Society of Chemistry, London, UK,\u00a0<strong>2008<\/strong>, pp. 293\u2013318. ISBN: 978-1-84755-796-4<\/p>\n<p>DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1039\/9781847557964-00291\">10.1039\/9781847557964-00291<\/a><\/p>\n<p>\u00a0<\/p>\n<p>\u00a0<\/p>\n<div>\n<div><\/div>\n<\/div>\n<h2>Patents<\/h2>\n<p>\u00a0<\/p>\n<p><strong>16.<\/strong> Multivalent degraders<\/p>\n<p>Ciulli, Alessio; Makukhin, Nikolai; Bond, Adam<\/p>\n<p>PCT Int. Appl. (PCT\/GB2024\/051314, 21\/05\/2024), <a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2024241046\">WO 2024\/241046<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>15.<\/strong> Aminopyrimidinyl derivatives for the treatment of Parkinson\u2019s disease<\/p>\n<p>Ciulli, Alessio; Liu, Xingui; Makukhin, Nikolai; Alessi, Dario; Kalogeropulou, Alexia<\/p>\n<p>PCT Int. Appl. (PCT\/GB2023\/051223, 10\/05\/2023), <a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2023218187&amp;_cid=P22-M09WKT-92737-1\">WO 2023\/218187<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>14.<\/strong>\u00a0KRAS degrading compounds comprising annulated 2-amino-3-cyano thiophenes<\/p>\n<p>Broeker, Joachim;\u00a0Ciulli, Alessio;\u00a0Diers, Emelyne;\u00a0Gollner, Andreas;\u00a0Goodwin-Tindall, Jake;\u00a0Farnaby, William;\u00a0Kofink, Christiane;\u00a0Mantoulidis, Andreas;\u00a0McLennan, Ross;\u00a0Popow, Johannes;\u00a0Schmiedel, Martin;\u00a0Smethurst, Christian Alan Paul;\u00a0Trainor, Nicole;\u00a0Weinstabl, Harald;\u00a0Zhong, Siying,\u00a0Zollman, David;\u00a0Abbott, Jason;\u00a0Cui, Jianwen;\u00a0Fesik, Stephen W.;\u00a0Little, Andrew;\u00a0Sarkar, Dhruba;\u00a0Waterson, Alex<\/p>\n<p>PCT Int. Appl. (PCT\/EP2022\/083950, 30\/11\/2022),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2023099620&amp;_cid=P20-LIR9Y3-25417-1\">WO 2023\/099620<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>13.<\/strong> Novel tetrahydroquinolines and Proteolysis Targeting Chimera (PROTACs) comprising them as degraders of SMARCA<\/p>\n<p>Ciulli, Alessio; Diers, Emelyne; Farnaby, William; Greb, Peter; Kofink, Christiane; Steurer, Steffen; Trainor, Nicole; Weinstabl, Harald<\/p>\n<p>PCT Int. Appl. (PCT\/EP2022\/076850, 27\/09\/2022), <a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2023052363&amp;_cid=P10-M31M6A-89245-1\">WO\/2023\/052363<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>12.<\/strong>\u00a0Protein degrader<\/p>\n<p>Ciulli, Alessio; Bond, Adam George; Craigon, Connor George; Chan, Kwok-Ho; Testa, Andrea; Alessi, Dario<\/p>\n<p>PCT Int. Appl. (23\/09\/2022),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2023047121&amp;_cid=P20-LI6D7D-76421-1\">WO 2023\/047121<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>11.<\/strong>\u00a0Improved small molecules<\/p>\n<p>Ciulli, Alessio; Testa, Andrea; Maniaci, Chiara; Makukhin, Nikolai; Imaide, Satomi; Daniels, Danette; Riching, Kristin<\/p>\n<p>PCT Int. Appl. (19\/10\/2021),\u00a0<a href=\"https:\/\/patentscope2.wipo.int\/search\/en\/detail.jsf?docId=WO2022101603\">WO 2022\/101603<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>10.<\/strong>\u00a0Proteolysis targeting chimera (Protacs) as degraders of SMARCA2 and\/or SMARCA4<\/p>\n<p>Ciulli, Alessio; Dank, Christian; Diers, Emelyne; Farnaby, William; Roy, Michael; Steurer, Steffen; Trainor, Nicole<\/p>\n<p>PCT Int. Appl. (23\/04\/2020),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2020078933\">WO 2020\/078933<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>9.<\/strong>\u00a0Bifunctional molecules for targeting USP14<\/p>\n<p>Testa, Andrea; Hughes, Scott J.; Butcher, Steven P.;\u00a0Ciulli, Alessio<\/p>\n<p>PCT Int. Appl. (19\/12\/2019),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2019238886\">WO 2019\/238886<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>8.<\/strong>\u00a0Bifunctional molecules for targeting RPN11<\/p>\n<p>Ciulli, Alessio; Testa, Andrea; Hughes, Scott J.; Butcher, Steven P.<\/p>\n<p>PCT Int. Appl. (19\/12\/2019),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2019238817\">WO 2019\/238817<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>7.<\/strong>\u00a0Bifunctional molecules for targeting UCHL5<\/p>\n<p>Ciulli, Alessio; Testa, Andrea; Hughes, Scott J.; Butcher, Steven P.<\/p>\n<p>PCT Int. Appl. (19\/12\/2019),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2019238816\">WO 2019\/238816<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>6.<\/strong>\u00a0Small molecules<\/p>\n<p>Ciulli, Alessio; Maniaci, Chiara; Hughes, Scott J.; Testa, Andrea<\/p>\n<p>PCT Int. Appl. (18\/10\/2018),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2018189554\">WO 2018\/189554<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>5.<\/strong>\u00a0Fluorohydroxyproline derivatives useful in the preparation of proteolysis targeting chimeras<\/p>\n<p>Ciulli, Alessio; Testa, Andrea<\/p>\n<p>PCT Int. Appl. (22\/03\/2018),\u00a0<a href=\"http:\/\/patentscope.wipo.int\/search\/en\/WO2018051107\">WO 2018\/051107<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>4.<\/strong>\u00a0Derivatives of 1-[(cyclopentyl or 2-pyrrolidinyl)carbonylaminomethyl]-4-(1,3-thiazol-5-yl) benzene which are useful for the treatment of proliferative, autoimmune or inflammatory diseases<\/p>\n<p>Ciulli, Alessio; Zengerle, Michael; Chan, Kwok-Ho<\/p>\n<p>PCT Int. Appl. (22\/09\/2016),\u00a0<a href=\"http:\/\/patentscope.wipo.int\/search\/en\/WO2016146985\">WO 2016\/146985<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>3.<\/strong>\u00a0Enzyme Functional Probes<\/p>\n<p>Shiao, Enrique, L.; Baud, Matthias, G. J.; Ciulli, Alessio; Chan, Kwok-Ho; Zengerle, Michael<\/p>\n<p>PCT Int. Appl. (04\/06\/2015),\u00a0<a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2015079259\">WO 2015\/079259<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>2.<\/strong>\u00a0Compounds and Methods for the Inhibition of VCB E3 Ubiquitin Ligase.<\/p>\n<p>Crews, Craig, M.; Buckley, Dennis; Ciulli, Alessio; Jorgensen, William; Gareiss, Peter, C.; Van Molle, Inge; Gustafson, Jeffrey; Tae, Hyun-Seop; Michel, Julien; Hoyer, Dentin, W.; Roth, Anke, G.; Harling, John, D.; Smith, Ian Edward, D.; Miah, Afjal, H.; Campos, Sebastien, A.; Le, Joelle<\/p>\n<p>PCT Int. Appl. (18\/07\/2013),\u00a0<a href=\"http:\/\/patentscope.wipo.int\/search\/en\/WO2013106646\">WO 2013\/106646<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>1.<\/strong>\u00a0Compounds &amp; Methods for the Enhanced Degradation of Targeted Proteins &amp; Other Polypeptides by an E3 Ubiquitin Ligase.<\/p>\n<p>Crews, Craig, M.; Buckley, Dennis; Ciulli, Alessio; Jorgensen, William; Gareiss, Peter, C.; Van Molle, Inge; Gustafson, Jeffrey; Tae, Hyun-Seop; Michel, Julien; Hoyer, Dentin, W.; Roth, Anke, G.; Harling, John, D.; Smith, Ian Edward, D.; Miah, Afjal, H.; Campos, Sebastien, A.; Le, Joelle<\/p>\n<p>PCT Int. Appl. (18\/07\/2013),\u00a0<a href=\"http:\/\/patentscope.wipo.int\/search\/en\/WO2013106643\">WO 2013\/106643<\/a><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Book Chapters \u00a0 126.\u00a0Ramachandran, S., Szewczyk, M., Barghout, S.H., Ciulli, A., Barsyte-Lovejoy, D., Vu, V. HiBiT Cellular Thermal Shift Assay (HiBiT CETSA). Methods Mol. Biol.\u00a02023, vol. 2706, pp. 149-165 PMID: 37558947 \u00a0 121.\u00a0Ciulli, A.,* Hsia, O. PROTAC Degraders: Mechanism, Recent Advances, and Future Challenges, In:\u00a0\u2018Protein Homeostasis in Drug Discovery: A Chemical Biology Perspective\u2019 M. Kostic [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":168,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-774","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=774"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/774\/revisions"}],"predecessor-version":[{"id":4498,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/774\/revisions\/4498"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}