{"id":771,"date":"2023-11-16T12:04:44","date_gmt":"2023-11-16T12:04:44","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=771"},"modified":"2026-01-26T14:19:57","modified_gmt":"2026-01-26T14:19:57","slug":"phd-studies","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/publications\/phd-studies\/","title":{"rendered":"PhD studies and pre-PhD studies"},"content":{"rendered":"<h2>PhD studies: Professor Chris Abell<\/h2>\n<p><strong>Refereed Papers In Primary Journals<\/strong><\/p>\n<p>* A.C. Corresponding Author<\/p>\n<p>\u00a0<\/p>\n<p><strong>9<\/strong>. Kerbarh, O., Ciulli, A., Chirgadze, D.Y., Blundell, T.L., Abell, C.<\/p>\n<p>Nucleophile selectivity of chorismate-utilizing enzymes.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1002\/cbic.200700019\"><em>ChemBioChem<\/em>\u00a0<strong>2007<\/strong>,\u00a0<em>8<\/em>, 622\u2013624<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>8<\/strong>. Ciulli, A., Chirgadze, D.Y., Smith, A.G., Blundell, T.L., Abell, C.<\/p>\n<p>Crystal structure of ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change and cooperativity.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1074\/jbc.M611171200\"><em>J. Biol. Chem.<\/em>\u00a0<strong>2007<\/strong>,\u00a0<em>282<\/em>, 8487\u20138497<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>7<\/strong>. Ciulli, A., Lobley, C.M.C., Tuck, K.L., Smith, A.G., Blundell, T.L., Abell, C.<\/p>\n<p>pH tuneable binding of 2\u2032-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1107\/S0907444906044465\"><em>Acta Cryst. D63<\/em>\u00a0<strong>2007<\/strong>, 171\u2013178<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>6<\/strong>. Ciulli, A., Williams, G., Smith, A.G., Blundell, T.L., Abell, C.<\/p>\n<p>Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/jm060490r\"><em>J. Med. Chem.<\/em>\u00a0<strong>2006<\/strong>,\u00a0<em>49<\/em>, 4992\u20135000<\/a><\/p>\n<ul>\n<li>Highlighted twice in the Faculty of 1000 Biology\u00a0<a href=\"https:\/\/f1000.com\/prime\/1044116\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" id=\"bg\" src=\"https:\/\/cdn.f1000.com.s3.amazonaws.com\/images\/badges\/badgef1000.gif\" alt=\"Access the recommendation on F1000Prime\"><\/a><\/li>\n<li>Highlighted\u00a0in the Microcal Autumn 2007 Newsletter<\/li>\n<li>Listed 13th Most-Accessed Article in Jul\u2013Sept 2006<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>5.<\/strong> Kerbarh, O., Ciulli, A., Howard, N.I., Abell, C.<\/p>\n<p>Salicylate biosynthesis: over-expression, purification and characterization of Irp9, a bifunctional salicylate synthase from\u00a0<em>Yersinia enterocolitica<\/em>.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1128\/JB.187.15.5061-5066.2005\"><em>J. Bacteriol.<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>187<\/em>, 5061\u20135066<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>4<\/strong>. Ciulli, A.,* Abell, C.<\/p>\n<p>Biophysical tools to monitor enzyme-ligand interactions of enzymes involved in vitamin biosynthesis.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1042\/BST0330767\"><em>Biochem. Soc. Trans.<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>33<\/em>, 767\u2013771<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>3<\/strong>. Lobley, C.M.C., Ciulli, A., Whitney, H.M., Williams, G., Smith, A.G., Abell, C., Blundell, T.L.<\/p>\n<p>The crystal structure of\u00a0<em>Escherichia coli<\/em>\u00a0ketopantoate reductase with NADP+ bound.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/bi0502036\"><em>Biochemistry<\/em>\u00a0<strong>2005<\/strong>,\u00a0<em>44<\/em>, 8930\u20138939<\/a><\/p>\n<p>\u00a0<\/p>\n<h2>Pre-PhD Studies<\/h2>\n<p><strong>2<\/strong>. Banci, L., Bertini, I., Ciulli, A., Fragai, M., Luchinat, C., Terni, B.<\/p>\n<p>Expression and high yield production of the catalytic domain of matrix metalloproteinase 12 and of an active mutant with increased solubility.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/S1381-1169(03)00493-X\"><em>J. Mol. Cat. A: Chem.<\/em>\u00a0<strong>2003<\/strong>,\u00a0<em>204-205<\/em>, 401\u2013408<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>1.<\/strong> Bashall, A., Ciulli, A., Harron, E.A., Lawson, G.T., McPartlin, M., Mosquera, M.E.G., Wright, D.S.<\/p>\n<p>Effects of meta-substitution on aggregation in the cubanes [SnNR]4{R = [2-Me-5-MeOC6H3], [2,5-(MeO)2C6H3] and [3,5-(MeO)2C6H3]}.<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1039\/b107425c\"><em>J. Chem. Soc. Dalton Trans.<\/em>\u00a0<strong>2002<\/strong>,\u00a0<em>6<\/em>, 1046\u20131050<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>PhD studies: Professor Chris Abell Refereed Papers In Primary Journals * A.C. Corresponding Author \u00a0 9. Kerbarh, O., Ciulli, A., Chirgadze, D.Y., Blundell, T.L., Abell, C. Nucleophile selectivity of chorismate-utilizing enzymes. ChemBioChem\u00a02007,\u00a08, 622\u2013624 \u00a0 8. Ciulli, A., Chirgadze, D.Y., Smith, A.G., Blundell, T.L., Abell, C. Crystal structure of ketopantoate reductase in a ternary complex with [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":168,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-771","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/771","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=771"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/771\/revisions"}],"predecessor-version":[{"id":4497,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/771\/revisions\/4497"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=771"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}