Refereed Papers In Primary Journals<\/strong><\/p>\n * A.C. Corresponding Author<\/p>\n \u00a0<\/p>\n 25.<\/strong> Macaulay, K.M., Heath, G.A., Ciulli, A., Murphy, A.M., Abell, C., Carr, J.P., Smith, A.G.<\/p>\n The biochemical properties of the two\u00a0Arabidopsis thaliana<\/em>\u00a0isochorismate synthases.<\/p>\n Biochem. J.<\/em>\u00a02017<\/strong>,\u00a0474 (10)<\/em>, 1579-1590<\/a><\/p>\n \u00a0<\/p>\n 24. <\/strong>Hung, A.W., Silvestre, H.L., Wen, S., George, G.P.C., Boland, J., Blundell, T.L., Ciulli, A., Abell, C.<\/p>\n Optimization of Inhibitors of\u00a0Mycobacterium tuberculosis<\/em>\u00a0Pantothenate Synthetase Based on Group Efficiency Analysis<\/p>\n ChemMedChem<\/em>\u00a02016<\/strong>,\u00a011(1)<\/em>, 38-42<\/a><\/p>\n \u00a0<\/p>\n (23.<\/strong> Ciulli A. book chapter<\/a>)<\/p>\n \u00a0<\/p>\n 22.<\/strong>\u00a0Silvestre, H.L., Blundell, T.L., Abell, C., Ciulli, A.*<\/p>\n Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.<\/p>\n Proc. Natl. Acad. Sci. U.S.A.<\/em>\u00a02013<\/strong>,\u00a0110 (32)<\/em>, 12984-12989<\/a><\/p>\n \u00a0<\/p>\n (21.<\/strong> \u015aled\u017a et al. book chapter<\/a>)<\/p>\n \u00a0<\/p>\n 20<\/strong>. Hudson, S.A., McLean, K.J., Surade, S., Yang, Y.-Q., Leys, D., Ciulli, A., Munro, A.W., Abell, C.<\/p>\n Application of fragment screening and merging to the discovery of inhibitors of the\u00a0Mycobacterium tuberculosis<\/em>\u00a0cytochrome P450 CYP121.<\/p>\n Angew. Chem. Int. Ed.<\/em>\u00a02012<\/strong>,\u00a051<\/em>, 9311\u20139316<\/a><\/p>\n \u00a0<\/p>\n 19<\/strong>. Dias, M.V.B., Snee, W.C., Bromfield, K.M., Payne, R.J., Palaninathan, S.K., Ciulli, A., Howard, N.I., Abell, C., Sacchettini, J.C., Blundell, T.L.<\/p>\n Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of\u00a0Mycobacterium tuberculosis<\/em>.<\/p>\n Biochem. J.<\/em>\u00a02011<\/strong>,\u00a0436 (3)<\/em>, 729\u201339<\/a><\/p>\n \u00a0<\/p>\n 18<\/strong>. \u015aled\u017a, P., Silvestre, H.L., Hung, A.W., Ciulli, A., Blundell, T.L., Abell, C.<\/p>\n Optimization of the Interligand Overhauser Effect for fragment linking: application to inhibitor discovery against\u00a0Mycobacterium tuberculosis\u00a0<\/em>pantothenate synthetase.<\/p>\n J. Am. Chem. Soc.<\/em>\u00a02010<\/strong>,\u00a0132<\/em>, 4544\u20134545<\/a><\/p>\n \u00a0<\/p>\n 16<\/strong>. Scott, D.E., Dawes, G.J., Ando, M., Abell, C.*, Ciulli, A.*<\/p>\n A fragment-based approach to probing adenosine recognition sites using dynamic combinatorial chemistry.<\/p>\n ChemBioChem<\/em>\u00a02009<\/strong>,\u00a010<\/em>, 2772\u20132779<\/a><\/p>\n \u00a0<\/p>\n 15<\/strong>. Hung, A.W., Silvestre, H.L., Wen, S., Ciulli, A., Blundell, T.L., Abell, C.<\/p>\n Application of fragment growing and fragment linking to the discovery of inhibitors of\u00a0Mycobacterium tuberculosis<\/em>\u00a0pantothenate synthetase.<\/p>\n Angew. Chem. Int. Ed.<\/em>\u00a02009<\/strong>,\u00a048<\/em>, 8452\u20138456<\/a><\/p>\n \u00a0<\/p>\n (14.<\/strong> Ciulli et al. book chapter<\/a>)<\/p>\n \u00a0<\/p>\n 13<\/strong>. Ciulli, A.*, Scott, D.E., Ando, M., Reyes, F., Saldanha, S.A., Tuck, K.L., Chirgadze, D.Y., Blundell, T.L., Abell, C.*<\/p>\n Inhibition of\u00a0Mycobacterium tuberculosis<\/em>\u00a0pantothenate synthetase by analogues of the reaction intermediate.<\/p>\n ChemBioChem<\/em>\u00a02008<\/strong>,\u00a09<\/em>, 2606\u20132611<\/a><\/p>\n \u00a0<\/p>\n 12.<\/strong> Ciulli, A., Abell, C.<\/p>\n Fragment-based approaches to enzyme inhibition.<\/p>\n Curr. Opin. Biotech.<\/em>\u00a02007<\/strong>,\u00a018 (6)<\/em>, 489\u2013496<\/a><\/p>\n \u00a0<\/p>\n 11<\/strong>. Scott, D.E., Ciulli, A., Abell, C.<\/p>\n Coenzyme biosynthesis: enzyme mechanism, structure and inhibition.<\/p>\n Nat. Prod. Rep.\u00a0<\/em>2007<\/strong>,\u00a024<\/em>, 1009\u20131026<\/a><\/p>\n \u00a0<\/p>\n\n
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