{"id":4117,"date":"2025-10-06T11:21:30","date_gmt":"2025-10-06T10:21:30","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=4117"},"modified":"2026-01-26T14:34:12","modified_gmt":"2026-01-26T14:34:12","slug":"2018-2","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/publications\/2018-2\/","title":{"rendered":"2021-2018 Publications"},"content":{"rendered":"<h3><strong>2021<\/strong><\/h3>\n<p>\u00a0<\/p>\n<p><strong>109.<\/strong>\u00a0Tarantelli, C., Cannas, E., Ekeh, H., Moscatello, C., Gaudio, E., Cascione, L., Napoli, S., Rech, C., Testa, A., Maniaci, C., Rinaldi, A., Zucca, E., Stathis, A., Ciulli, A., Bertoni, F.<\/p>\n<p>The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type<\/p>\n<p><a href=\"https:\/\/doi.org\/10.37349\/etat.2021.00065\"><em>Explor. Target Antitumor Ther.<\/em>\u00a0<strong>2021,\u00a0<\/strong><em>2<\/em>, 586<\/a><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01496\">\u2013<\/a><a href=\"https:\/\/doi.org\/10.37349\/etat.2021.00065\">601<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36046113\/\">36046113<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc9400774\/\">PMC9400774<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>108.<\/strong>\u00a0Klein, V.G., Bond, A.G., Craigon, C., Lokey, R.S.*, Ciulli, A.*<\/p>\n<p>Amide-to-ester substitution as a strategy for optimizing PROTAC permeability and cellular activity<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01496\"><em>J. Med. Chem.\u00a0<\/em><strong>2021<\/strong>,\u00a0<em>64 (24)<\/em>, 18082\u201318101<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34881891\/\">34881891<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8713283\/\">PMC8713283<\/a><\/li>\n<li>Pre-print posted at ChemRxiv on 5 July 2021; DOI:\u00a0<a href=\"https:\/\/doi.org\/10.33774\/chemrxiv-2021-47tqn\">10.33774\/chemrxiv-2021-47tqn<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/05\/07\/amide-to-ester-substitution\/\">here<\/a> and <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/09\/12\/new-paper-amide-to-ester-substitution-as-a-strategy-for-optimizing-protac-permeability-and-cellular-activity\/\">here<\/a><\/li>\n<li>Listed as 2nd\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Most Read Article<\/a>\u00a0in the journal (1-month timeframe, Jan 2022)<\/li>\n<li>Featured as Literature Spotlight in the monthly EFMC MedChemBioWatch newsletter (<a href=\"https:\/\/www.efmc.info\/medchemwatch.php?langue=english&amp;cle_menus=1187970203&amp;cle_data=775&amp;cle_parag=1299#it_1299\">February 2022<\/a>)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>107.<\/strong>\u00a0M\u00fcller, S., Ackloo, S., Al Chawaf, A., Al-Lazikani, B., Antolin, A., Baell, J.B., Beck, H., Beedie, S., Betz, U.A.K., Arruda Bezerra, G., Brennan, P.E., Brown, D., Brown,\u00a0P.J.,\u00a0Bullock, A.N., Carter, A.J., Chaikuad, A., Chaineau, M., Ciulli, A., Collins, I., Dreher, J., Drewry, D., Edfeldt, K., Edwards, A.M., Egner, U., Frye, S.V., Fuchs,\u00a0S.M.,\u00a0Hall, M.D., Hartung, I.V., Hillisch, A., Hitchcock, S.H., Homan, E., Kannan, N., Kiefer, J.R., Knapp, S., Kostic, M., Kubicek, S., Leach, A.R., Lindemann, S., Marsden, B.D., Matsui, H., Meier, J.L., Merk, D., Michel, M., Morgan, M.R., Mueller-Fahrnow, A., Owen, D.R., Perry, B.G., Rosenberg, S.H., Singh Saikatendu, K., Schapira, M., Scholten, C., Sharma, S., Simeonov, A., Sundstr\u00f6m, M., Superti-Furga, G., Todd, M.H., Tredup, C., Vedadi, M., von Delft, F., Willson, T.M., Winter, G.E., Workman, P., Arrowsmith,\u00a0C.H.<\/p>\n<p>Target 2035 \u2013 update on the quest for a probe for every protein<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1039\/D1MD00228G\"><em>RSC Med. Chem.<\/em>\u00a0<strong>2022<\/strong>,\u00a0<em>13<\/em>, 13-21<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35211674\/\">35211674<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8792830\/\">PMC8792830<\/a><\/li>\n<li>Selected as the\u00a0<a href=\"https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2022\/md\/d2md90003c\">inside front cover<\/a>\u00a0of the issue.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>106.<\/strong>\u00a0Laveglia, V., Giachetti, A., Cerofolini, L., Haubrich, K., Fragai, M., Ciulli,\u00a0A., Rosato, A.<\/p>\n<p>Automated Determination of Nuclear Magnetic Resonance Chemical Shift Perturbations in Ligand Screening Experiments: The PICASSO Web Server<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1021\/acs.jcim.1c00871\"><em>J. Chem. Inf. Model.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>61 (12)<\/em>, 5726\u20135733<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34843238\/\">34843238<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8715503\/\">PMC8715503<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>105.<\/strong>\u00a0Imaide, S., Riching, K.M., Makukhin, N., Vetma, V., Whitworth, C., Hughes, S.J., Trainor, N., Mahan, S.D., Murphy, N., Cowan, A.D., Chan, K.-H., Craigon, C., Testa, A., Maniaci, C., Urh, M.,\u00a0Daniels, D.L.*;\u00a0Ciulli,\u00a0A.*<\/p>\n<p>Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41589-021-00878-4\"><em>Nat. Chem. Biol.\u00a0<\/em><strong>2021<\/strong>,\u00a0<em>17 (11)<\/em>, 1157\u20131167<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34675414\/\">34675414<\/a>\u00a0PMCID:<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7611906\/\">\u00a0PMC7611906<\/a><\/li>\n<li>Pre-print posted at ChemRxiv on 12 November 2020; DOI:\u00a0<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv.13218695.v1\">10.26434\/chemrxiv.13218695.v1<\/a><\/li>\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/10\/10\/our-new-paper-in-nature-chemical-biology-reports-trivalent-protacs-as-a-strategy-to-boost-targeted-protein-degraders-mechanism-of-action\/\">here<\/a><\/li>\n<li>Covered in\u00a0<a href=\"https:\/\/www.dundee.ac.uk\/stories\/three-heads-are-better-two-drug-discovery-concept\">UoD<\/a>\u00a0and\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/10\/22\/three-heads-are-better-than-two-in-drug-discovery-concept\/\">SLS<\/a>\u00a0News websites<\/li>\n<li>Covered as joint Dundee-Promega Press Release in\u00a0<a href=\"https:\/\/www.businesswire.com\/news\/home\/20211021005149\/en\/Research-Reveals-Trivalent-PROTACs-More-Potent-in-Targeted-Protein-Degradation\">BusinessWire<\/a><\/li>\n<li>Read the article Open Access as SharedIt version\u00a0<a href=\"https:\/\/rdcu.be\/czWSD\">here<\/a><\/li>\n<li>Highlighted in Blog\u00a0<a href=\"https:\/\/www.promegaconnections.com\/the-power-of-binding-using-trivalent-protacs-to-enhance-protein-degradation\/\">Promega Connections<\/a><\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/cen.acs.org\/biological-chemistry\/Trivalent-PROTACs-speed-protein-degradation\/99\/i40\">Chemical &amp; Engineering News<\/a><\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/www.biocentury.com\/article\/640436\/esgct-preclinical-roundup-plus-generation-pionyr-and-more\">Biocentury<\/a><\/li>\n<li>Recommended in\u00a0<a href=\"https:\/\/facultyopinions.com\/prime\/741017315\">Faculty Opinions<\/a><\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/www.biopharmatrend.com\/post\/469-interview-targeted-protein-degradation-a-new-approach-to-small-molecule-therapeutics\/\">BiopharmaTrend<\/a><\/li>\n<li>Our trivalent PROTAC degrader\u00a0<a href=\"https:\/\/www.tocris.com\/products\/sim1_7432\">SIM1<\/a>\u00a0is available from Tocris (September 2021)<\/li>\n<li>The non-degrading epimer\u00a0<a href=\"https:\/\/www.tocris.com\/products\/cis-sim1_7433\">cis-SIM1<\/a>\u00a0is also available from Tocris (November 2021)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>104.<\/strong>\u00a0Riching, K.M., Vasta, J.D., Hughes, S.J., Zoppi, V., Maniaci, C., Testa, A., Urh, M., Ciulli, A.*, Daniels, D.L.*<\/p>\n<p>Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1016\/j.crchbi.2021.100009\"><em>Curr. Res. Chem. Biol.<\/em>,\u00a0<strong>2021<\/strong>,\u00a0<em>1<\/em>, 100009<\/a><\/p>\n<ul>\n<li>2nd\u00a0<a href=\"https:\/\/www.sciencedirect.com\/journal\/current-research-in-chemical-biology\">Most Downloaded Article<\/a>\u00a0in the journal (April 2022)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>103.<\/strong>\u00a0Bond,\u00a0A.G.,\u00a0Craigon, C., Chan, K.-H.,\u00a0Testa, A., Karapetsas, A., Fasimoye, R., Macartney, T., Blow, J.J., Alessi, D.R., Ciulli, A.*<\/p>\n<p>Development of BromoTag: A \u201cBump-and-Hole\u201d\u2013PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.1c01532\"><em>J. Med. Chem.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>64 (20)<\/em>, 15477\u201315502<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34652918\/\">34652918<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8558867\/\">PMC8558867<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/10\/15\/introducing-bromotag-and-agb1\/\">here<\/a><\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/www.dundee.ac.uk\/stories\/tag-tech-provides-insight-undruggable-diseases\">UoD<\/a>\u00a0and\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/10\/19\/tag-tech-provides-insight-into-undruggable-diseases\/\">SLS<\/a>\u00a0News websites<\/li>\n<li>Listed amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Most Read Articles<\/a>\u00a0in the journal (1-month timeframe, November 2021)<\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1055\/s-0041-1737171\">SynFacts<\/a><\/li>\n<li>Our BromoTag-specific bumped-PROTAC degrader\u00a0<a href=\"https:\/\/www.tocris.com\/products\/bromotag-agb1_7686\">AGB1<\/a>\u00a0is available from Tocris (April 2022)<\/li>\n<li>The non-degrading epimer\u00a0<a href=\"https:\/\/www.tocris.com\/products\/bromotag-cis-agb1_7687\">cis-AGB1<\/a>\u00a0is also available from Tocris (April 2022)<\/li>\n<li>A second BromoTag-specific bumped-PROTAC degrader\u00a0<a href=\"https:\/\/www.bio-techne.com\/p\/small-molecules-peptides\/bromotag-agb3_7688\">AGB3<\/a>\u00a0is also available from Tocris (November 2022)<\/li>\n<li>Addition\/Correction published (Web): January 22, 2025. DOI: <a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00108\">10.1021\/acs.jmedchem.5c00108<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>102.<\/strong>\u00a0Castro, G.V, Ciulli, A.*<\/p>\n<p>Estimating the cooperativity of PROTAC-induced ternary complexes using 19F NMR displacement assay<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1039\/D1MD00215E\"><em>RSC Med. Chem.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>12<\/em>, 1765-1770<\/a><\/p>\n<ul>\n<li>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34778777\/\">\u00a034778777<\/a>\u00a0PMCID:<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8528210\/\">\u00a0PMC8528210<\/a><\/li>\n<li>Pre-print posted at ChemRxiv on 21 June 2021; DOI:\u00a0<a href=\"https:\/\/doi.org\/10.33774\/chemrxiv-2021-zj19k\">10.33774\/chemrxiv-2021-zj19k<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/06\/06\/estimating-the-cooperativity-of-protac\/\">here<\/a><\/li>\n<li>Correction published (Web): December 20, 2021. DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1039\/D1MD90045E\">10.1039\/D1MD90045E<\/a>\u00a0(Correction)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p>(<strong>100.<\/strong> &amp; <strong>101.<\/strong> Casement et al. and Bartoschik et al. <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/book-chapters-and-patents\/\">book chapters<\/a>)<\/p>\n<p>\u00a0<\/p>\n<p><strong>99.<\/strong>\u00a0Ciulli, A.*, Trainor, N.<\/p>\n<p>A beginner\u2019s guide to PROTACs and targeted protein degradation<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1042\/bio_2021_148\"><em>Biochem (Lond)<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>43 (5)<\/em>, 74\u201379<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37224698\/\">37224698<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/07\/23\/beginners-guide-to-protacs-and-targeted-protein-degradation-published\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>98.<\/strong>\u00a0Frost, J.; Rocha, S.*; Ciulli, A.*<\/p>\n<p>Von Hippel-Lindau (VHL) small molecule inhibitor binding increases stability and intracellular levels of VHL protein<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1016\/j.jbc.2021.100910\"><em>J. Biol. Chem.\u00a0<\/em><strong>2021<\/strong>,\u00a0<em>297 (2)<\/em>, 100910<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34174286\/\">34174286<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8313594\/\">PMC8313594<\/a><\/li>\n<li>Pre-print posted at BioRxiv on 12 April 2021; DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/2021.04.12.439487\">10.1101\/2021.04.12.439487<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/new-pre-print-vhl-inhibitor-binding-increases-intracellular-level-vhl\">here<\/a><\/li>\n<li>Julianty Frost is recipient of one of the\u00a0<a href=\"https:\/\/www.jbc.org\/tabor-awards\">2022 JBC Herbert Tabor Early Career Investigator Awards<\/a>, recognizing\u00a0first authors of exceptional JBC papers that appeared in the preceding year<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>97.<\/strong>\u00a0Ciulli, A.; Hamann, L.; Jahnke, W.; Kalgutkar, A.S.; Magauer, T.; Ritter, T.; Steadman, V.; Williams, S.D.; Winter, G.; Hoegenauer, K.; Krawinkler, K.H.; Stepan, A.F.<\/p>\n<p>The 2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry.<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1002\/cmdc.202100372\"><em>ChemMedChem<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>16 (15)<\/em>, 2417-2413<\/a><\/p>\n<ul>\n<li>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34114371\/\">\u00a034114371<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>96.<\/strong>\u00a0Ciulli, A.*; Wertz, I.E.*<\/p>\n<p>Editorial overview: Hot targets and new modalities.<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1016\/j.cbpa.2021.04.010\"><em>Curr. Opin. Chem. Biol.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>62<\/em>, A1-A3<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34116929\/\">34116929<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>95.<\/strong>\u00a0Pietrobono, S.; Gaudio, E.; Gagliardi, S.; Zitani, M.; Carrassa, L.; Migliorini, F.; Petricci, E.; Manetti, F.; Makukhin, N.; Bond, A.G.; Paradise, B.D.; Ciulli, A.; Fernandez-Zapico, M.E.; Bertoni, F.; Stecca, B.<\/p>\n<p>Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1038\/s41388-021-01783-9\"><em>Oncogene<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>40<\/em>, 3799-3814<\/a><\/p>\n<ul>\n<li>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33958721\/\">\u00a033958721<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8175236\/\">PMC8175236<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>94.<\/strong>\u00a0Farnaby, W.; Koegl, M.; McConnell, D.B.; Ciulli, A.<\/p>\n<p>Transforming targeted cancer therapy with PROTACs: A forward-looking perspective<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.coph.2021.02.009\"><em>Curr. Opin. Pharmacol.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>57<\/em>, 175-183<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33799000\/\">33799000<\/a><\/li>\n<li>See more info\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2021\/03\/30\/review-on-the-present-and-future-of-protacs-for-cancer-therapy\/\">here<\/a><\/li>\n<li>2nd\u00a0<a href=\"https:\/\/www.journals.elsevier.com\/current-opinion-in-pharmacology\/most-downloaded-articles\">Most Downloaded Article<\/a>\u00a0in the journal in the last 3 months (August 2021)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>93.<\/strong>\u00a0Ramachandran, S.; Ciulli, A.*<\/p>\n<p>Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.sbi.2020.10.009\"><em>Curr. Opin. Struct. Biol.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>67<\/em>, 110-119<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33271439\/\">33271439<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/11\/11\/building-and-hijacking-ubiquitination-machineries-by-protacs\/\">here<\/a><\/li>\n<li>Top\u00a0<a href=\"https:\/\/www.sciencedirect.com\/journal\/current-opinion-in-structural-biology\">Most Downloaded Article<\/a>\u00a0in the journal (April 2021)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>92.<\/strong>\u00a0Ishida, T., Ciulli, A.*<\/p>\n<p>E3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1177\/2472555220965528\"><em>SLAS Discov.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>26 (4)<\/em>, 484-502<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33143537\/\">33143537<\/a>\u00a0PMCID:<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8013866\/\">\u00a0PMC8013866<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/11\/03\/e3-ligase-ligands-for-protacs\/\">here<\/a><\/li>\n<li><a href=\"https:\/\/journals.sagepub.com\/home\/jbx#\">Most Read article<\/a>\u00a0in the journal in the last 6 months (August 2021)<\/li>\n<li>Honored with the\u00a0<a href=\"https:\/\/www.slas.org\/news-highlights\/news-center\/2022-news-releases\/slas-discovery-and-slas-technology-honor-annual-achievement-awardees\/\">2021 SLAS Discovery Readers Choice Award<\/a>, reflecting popularity among readers throughout 2021. Read more about this <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/10\/03\/readers-choice-award-for-tasuku-alessio\/\">here<\/a>.<\/li>\n<li>Top amongst\u00a0<a href=\"https:\/\/slas-discovery.org\/top-10\">SLAS Discovery\u2019s Editor\u2019s Top 10 for 2021<\/a>. Read the full Editorial\u00a0<a href=\"https:\/\/slas-discovery.org\/action\/showPdf?pii=S2472-5552%2822%2900010-7\">here<\/a><\/li>\n<li>Mentioned in SLAS ELN article: \u201cArt of the Review: SLAS Journals Authors Offer Expert Interpretation of Life Science Literature\u201d. Read the full article\u00a0<a href=\"https:\/\/www.slas.org\/publications\/electronic-laboratory-neighborhood\/2022-eln-articles\/art-of-the-review-slas-journals-authors-offer-expert-interpretation-of-life-science-literature\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>91.<\/strong>\u00a0Makukhin, N., Ciulli, A.*<\/p>\n<p>Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate- based phosphotyrosine analogues<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1039\/D0MD00272K\"><em>RSC Med. Chem.<\/em>\u00a0<strong>2021<\/strong>,\u00a0<em>12<\/em>, 8-23<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34041480\/\">34041480<\/a>\u00a0PMCID:<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8130623\/\">\u00a0PMC8130623<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/10\/15\/synthetic-medicinal-chemistry-of-phosphotyrosine-analogues-and-phosphomimetics\/\">here<\/a><\/li>\n<\/ul>\n<h3><strong>2020<\/strong><\/h3>\n<p>\u00a0<\/p>\n<p><strong>90. <\/strong>Klein, V.G., Townsend, C.E., Testa, A., Zengerle, M., Maniaci, C., Hughes, S.J., Chan, K.-H., Ciulli, A., Lokey, R.S.<\/p>\n<p>Understanding and improving the membrane permeability of VH032-based PROTACs<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.0c00265\"><em>ACS Med. Chem. Lett.<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>11 (9)<\/em>, 1732-1738<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32939229\/\">32939229<\/a>\u00a0PMCID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32939229\/\">PMC7488288<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/07\/30\/our-collaborative-work-with-scott-lokeys-lab-at-ucsc\/\">here<\/a><\/li>\n<li>Listed amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=amclct\">Most Read Articles<\/a>\u00a0in the journal (1-month timeframe: September 2020; 12-month timeframe: April 2021)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>89. <\/strong>Bond, A.G., Testa, A., Ciulli, A.*<\/p>\n<p>Stereoselective Synthesis of Allele-Specific BET Inhibitors<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1039\/D0OB01165G\"><em>Org. Biomol. Chem.<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>18<\/em>, 7533-7539<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32756710\/\">3275671<\/a><\/li>\n<li>Pre-print posted at ChemRxiv on 18 May 2020;\u00a0<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv.12317354.v1\">https:\/\/doi.org\/10.26434\/chemrxiv.12317354.v1<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/08\/05\/stereoselective-syntheses-of-allele-selective-bet-inhibitors-bumped-jq1\/\">here<\/a><\/li>\n<li>Selected as the front cover of the issue. Read more about it\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/10\/14\/on-the-front-cover-of-organic-biomolecular-chemistry\/\">here<\/a><\/li>\n<li>PDB code<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>88.<\/strong>\u00a0Cipriano, A., Sbardella, G.,* Ciulli, A.*<\/p>\n<p>Targeting epigenetic reader domains by chemical biology<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cbpa.2020.05.006\"><em>Curr. Opin. Chem. Biol.<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>57<\/em>, 82-94<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32739717\/\">32739717<\/a><\/li>\n<li>Read the article open access before September 18, 2020 via the Share Link\u00a0<a href=\"https:\/\/authors.elsevier.com\/a\/1bUfA4sz6M8Vwh\">here<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/07\/30\/our-review-on-probing-epigenetic-reader-domains-with-chemical-biology\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>87.<\/strong>\u00a0Whitworth, C., Ciulli, A.*<\/p>\n<p>Protein degraders extend their reach<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1038\/d41586-020-02211-w\"><em>Nature<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>584<\/em>, 193-194<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32728153\/\">32728153<\/a><\/li>\n<li>See Figure\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/07\/29\/carolyn-bertozzis-group-work-on-lytacs-is-now-published-in-nature\/\">here<\/a><\/li>\n<li>News &amp; Views article on Banik et al.\u00a0<em>Nature<\/em>\u00a02020, DOI:\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41586-020-2545-9\">10.1038\/s41586-020-2545-9<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>86.<\/strong>\u00a0Simpson, L.M., Macartney, T.J., Nardin, A., Fulcher, L.J., R\u00f6th, S., Testa, A., Maniaci, C., Ciulli, A., Ganley, I.G., Sapkota,\u00a0G.P.<\/p>\n<p>Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.chembiol.2020.06.013\"><em>Cell Chem. Biol.<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>27 (9)<\/em>, 1164-1180.e5<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32668203\/\">32668203\u00a0<\/a>PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7505680\/\">PMC7505680<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2020\/07\/15\/haloprotac-meets-adprom\/\">here<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41589-020-00683-5\">Nature Chemical Biology<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>85.<\/strong>\u00a0Testa, A., Hughes,\u00a0S.J.,\u00a0\u00a0Lucas, X., Wright, J.E., Ciulli, A.*<\/p>\n<p>Structure-Based Design of a Macrocyclic PROTAC<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1002\/anie.201914396\"><em>Angew. Chem. Int. Ed.<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>59<\/em>, 1727-1734<\/a><\/p>\n<ul>\n<li>PMID:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31746102\/\">31746102<\/a>\u00a0PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc7004083\/\">PMC7004083<\/a><\/li>\n<li>Pre-print posted at ChemRxiv on 22 July 2019;\u00a0<a href=\"http:\/\/dx.doi.org\/10.26434\/chemrxiv.8967941.v1\">DOI:\u00a010.26434\/chemrxiv.8967941.v1<\/a><\/li>\n<li>Selected as a \u201cHot paper\u201d by the Editors of\u00a0<em>Angew. Chem.<\/em>\u00a0and\u00a0<em>Angew. Chem. Int. Ed.<\/em><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/11\/19\/protacs-go-macrocyclic\/\">here<\/a><\/li>\n<li>The coordinates and structure factors of the associated co-crystal structure of the ternary complex between VHL, Brd4-BD2 and macroPROTAC-1 is available in the PDB with accession code\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6SIS\">6SIS<\/a>.<\/li>\n<li>Listed amongst the\u00a0<a href=\"https:\/\/onlinelibrary.wiley.com\/page\/journal\/15213773\/homepage\/2002_mostaccessed.html\">Most Accessed<\/a>\u00a0in the journal for the period 02\/2020 to 01\/2021 (April 2021)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p>(<strong>84.<\/strong> Zollman &amp; Ciulli <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/book-chapters-and-patents\/\">book chapter<\/a>)<\/p>\n<p>\u00a0<\/p>\n<p><strong>83.<\/strong>\u00a0Hassell-Hart, S., Runcie, A.C., Krojer, T., Doyle, J., Lineham, E., Ocasio, C.A., Neto, B.A.D., Fedorov, O., Marsh, G., Maple, H., Felix, R., Banks, R., Ciulli, A., Picaud, S., Filippakopoulos, P., von Delft, F., Brennan, P., Stewart, H.J.S., Chevassut, T.J., Walker, M., Austin, C., Morley, S., Spencer, J.<\/p>\n<p>Synthesis and Biological Investigation of (+)-JD1, an Organometallic BET Bromodomain Inhibitor<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.organomet.9b00750\"><em>Organometallics<\/em>\u00a0<strong>2020<\/strong>,\u00a0<em>39 (3)<\/em>, 408-416<\/a><\/p>\n<h3><strong>2019<\/strong><\/h3>\n<p>\u00a0<\/p>\n<p><strong>82.<\/strong>\u00a0Tovell, H., Testa, A., Zhou, H., Shpiro, N., Crafter, C., Ciulli, A.*, Alessi, D.R.*<\/p>\n<p>Design and characterization of SGK3-PROTAC1, an isoform specific SGK3 kinase PROTAC degrader<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acschembio.9b00505\"><em>ACS Chem. Biol.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>14 (9)<\/em>, 2024-2034<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/08\/28\/new-paper-design-and-characterization-of-sgk3-protac1-an-isoform-specific-sgk3-kinase-protac-degrader\/\">here<\/a><\/li>\n<li>Ranked Top amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=acbcct\">Most Read Articles<\/a>\u00a0in the journal (1-month timeframe, Sept-Oct 2019)<\/li>\n<li>Our SGK3 degrader SGK3-PROTAC1 is available from <a href=\"https:\/\/www.medchemexpress.com\/protac-sgk3-degrader-1.html\">MedChemExpress<\/a> and <a href=\"https:\/\/www.abmole.com\/products\/protac-sgk3-degrader-1.html\">AbMole<\/a><\/li>\n<li>Find out more about SGK3-PROTAC1 in the <a href=\"https:\/\/www.chemicalprobes.org\/sgk3-protac1\">Chemical Probes Portal<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>81.<\/strong>\u00a0Maniaci, C., Ciulli, A.*<\/p>\n<p>Bifunctional chemical probes inducing protein-protein interactions<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cbpa.2019.07.003\"><em>Curr. Opin. Chem. Biol.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>52<\/em>, 145-156<\/a><\/p>\n<ul>\n<li>Read the article open access until 2nd October 2019 via the Share Link\u00a0<a href=\"https:\/\/authors.elsevier.com\/a\/1ZYv5_V672DHBG\">here<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/08\/13\/our-review-on-bispecific-small-molecules-that-bring-proteins-together-is-published-in-current-opinion-in-chemical-biology\/\">here<\/a><\/li>\n<li>Ranked amongst\u00a0<a href=\"https:\/\/www.sciencedirect.com\/journal\/current-opinion-in-chemical-biology\">Most Popular Articles<\/a>\u00a0in the journal<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>80.<\/strong>\u00a0Ciulli, A.*, Farnaby, W.*<\/p>\n<p>Protein degradation for drug discovery. [Editorial]<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1016\/j.ddtec.2019.04.002\"><em>Drug Discov. Today Technol.<\/em>\u00a0<strong>2019<\/strong>\u00a0Apr 31: 1-3<\/a><\/p>\n<p>\u00a0<\/p>\n<p><strong>79.<\/strong>\u00a0Farnaby W, Koegl M, Roy MJ, Whitworth C, Diers E, Trainor N, Zollman D, Steurer S, Karolyi-Oezguer J, Riedmueller C, Gmaschitz T, Wachter J, Dank C, Galant M, Sharps B, Rumpel K, Traxler E, Gerstberger T, Schnitzer R, Petermann O, Greb P, Weinstabl H, Bader G, Zoephel A, Weiss-Puxbaum A, Ehrenh\u00f6fer-W\u00f6lfer K, W\u00f6hrle S, Boehmelt G, Rinnenthal J, Arnhof H, Wiechens N, Wu MY, Owen-Hughes T, Ettmayer P, Pearson M, McConnell DB*, Ciulli A.*<\/p>\n<p>BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/s41589-019-0294-6\"><em>Nat. Chem. Biol.\u00a0<\/em><strong>2019<\/strong>,\u00a0<em>15 (7)<\/em>, 672-680<\/a><\/p>\n<ul>\n<li>\n<div>A Publisher Correction to this article was published on 02 July 2019<\/div>\n<\/li>\n<li>\n<div>Featured in\u00a0<a href=\"https:\/\/www.dundee.ac.uk\/news\/2019\/boehringer-ingelheim-and-university-of-dundee-highlight-successful-protac-drug-discovery-program.php\">UoD<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.lifesci.dundee.ac.uk\/news\/2019\/jun\/11\/dundee-and-boehringer-ingelheim-scientists-degrade-undruggable-cancer-targets\">SLS<\/a>\u00a0News websites<\/div>\n<\/li>\n<li>Highlighted in\u00a0<a href=\"https:\/\/www.eurekalert.org\/pub_releases\/2019-06\/uod-bia061119.php\">EurekAlert<\/a>, the\u00a0<a href=\"https:\/\/www.news-medical.net\/news\/20190612\/Boehringer-Ingelheim-and-University-of-Dundee-extend-collaboration-to-develop-new-cancer-medicines.aspx\">Medical News<\/a>, and mentioned by\u00a0<a href=\"http:\/\/www.bioworld.com\/content\/gilead-pays-45m-front-nurix-discovery-deal\">BioWorld<\/a><\/li>\n<li>Read the article Open Access as SharedIt version\u00a0<a href=\"https:\/\/rdcu.be\/bF6NK\">here<\/a><\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/06\/10\/dundee-and-boehringer-ingelheim-scientists-degrade-undruggable-cancer-targets-smarca2-4\/\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the PDB. Accession codes of ternary complexes VCB (pVHL:ElonginC:ElonginB complex):PROTAC1:SMARCA2 bromodomain (PDB <a href=\"http:\/\/www.rcsb.org\/structure\/6HAY\">6HAY<\/a>), VCB:PROTAC2:SMARCA2 bromodomain (PDB\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6HAX\">6HAX<\/a>), and VCB:PROTAC2:SMARCA4 bromodomain (PDB\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6HR2\">6HR2<\/a>), as well as a binary complex between SMARCA2 bromodomain and SMARCA-BD ligand (PDB\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6HAZ\">6HAZ<\/a>)<\/li>\n<li>\n<div>Featured in a News &amp; Views article by Daffyd Owen in\u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41589-019-0305-7\">Nature Chemical Biology<\/a><\/div>\n<\/li>\n<li>\n<div>Featured in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1158\/2159-8290.CD-RW2019-094\">Cancer Discovery Research Watch<\/a><\/div>\n<\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/www.biocentury.com\/bc-innovations\/distillery-therapeutics\/2019-06-27\/chemically-induced-knockdown-smarca24-treat-aml\">Biocentury Innovation<\/a><\/li>\n<li>Highlighted in\u00a0<a href=\"http:\/\/dx.doi.org\/10.1055\/s-0039-1690608\">SynFacts<\/a><\/li>\n<li>Check out Darryl McConnell\u2019s video on Structure-Based SMARCA2 PROTAC Design\u00a0<a href=\"https:\/\/www.youtube.com\/watch?v=Z9pDMBDXVAo\">here<\/a>.<\/li>\n<li>Our SMARCA2\/4 degrader\u00a0<a href=\"https:\/\/opnme.com\/molecules\/smarca2-4-acbi1\">ACBI1<\/a>\u00a0(and cis-ACBI1) are available from Boehringer Ingelheim\u2019s OpnMe Portal: order for free, no strings attached! (Update July 2021:\u00a0in vivo DMPK data are now available online)<\/li>\n<li>Our VHL ligand\u00a0<a href=\"https:\/\/www.tocris.com\/products\/vh-101-phenol_6952\">\u201cVH101, phenol\u201d<\/a>\u00a0functionalized for PROTAC conjugation is available from Tocris (January 2020)<\/li>\n<li>Find out more about ACBI1 in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/acbi1?q=ACBI1\">Chemical Probes Portal<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>78.<\/strong>\u00a0Kung, W.-W., Ramachandran, S., Makukhin, N., Bruno, E., Ciulli, A.*<\/p>\n<p>Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1038\/s41467-019-10190-4\"><em>Nat. Commun.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>10<\/em>, 2534<\/a><\/p>\n<ul>\n<li>Pre-print posted at\u00a0bioRxiv 470187; 14 November 2018 doi:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/470187\">https:\/\/doi.org\/10.1101\/470187<\/a><\/li>\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/10\/06\/e3-ligase-socs2\/\">here<\/a><\/li>\n<li>Featured in\u00a0<a href=\"https:\/\/www.lifesci.dundee.ac.uk\/news\/2019\/jun\/10\/ciulli-lab-reveals-how-e3-ligase-socs2-latches-its-protein-substrates\">SLS News<\/a><\/li>\n<li>Read the SharedIt version\u00a0<a href=\"https:\/\/rdcu.be\/bGbSW\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the PDB. Accession codes of SOCS2:ElonginC:ElonginB in complex with EpoR (PDB\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6I4X\">6I4X<\/a>) and GHR peptides (PDBs\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6I5J\">6I5J<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6I5N\">6I5N<\/a>)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>77.<\/strong>\u00a0Tovell, H., Testa, A., Maniaci, C., Zhou, H., Prescott, A.R., Macartney, T., Ciulli, A.*, Alessi, D.R.*<\/p>\n<p>Rapid and reversible knockdown of endogenously tagged endosomal proteins via an optimized HaloPROTAC degrader<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acschembio.8b01016\"><em>ACS Chem. Biol.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>14 (5)<\/em>, 882-892<\/a><\/p>\n<ul>\n<li>Featured in the\u00a0<a href=\"https:\/\/www.lifesci.dundee.ac.uk\/news\/2019\/apr\/15\/hannah-tovell-and-ciulli-lab-publish-optimised-haloprotac-method\">SLS<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.ppu.mrc.ac.uk\/news\/hannah-tovell-and-ciulli-lab-publish-optimised-haloprotac-method-induce-post-translational\">MRC-PPU<\/a>\u00a0News websites<\/li>\n<li>Ranked Top amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=acbcct\">Most Read Articles<\/a>\u00a0in the journal (1-month timeframe, May 2019)<\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/04\/12\/our-collaboration-with-dario-alessis-lab-on-deploying-improved-haloprotacs-against-crispred-halo-tagged-endosomal-proteins-is-now-out-in-acs-chem-biol\/\">here<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>76.<\/strong>\u00a0Girardini, M., Maniaci, C., Hughes, S.J., Testa, A., Ciulli, A.*<\/p>\n<p>Cereblon vs VHL: Hijacking E3 Ligases Against Each Other Using PROTACs<\/p>\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.bmc.2019.02.048\"><em>Bioorg. Med. Chem.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>27 (12)<\/em>, 2466-2479<\/a><\/p>\n<ul>\n<li>Pre-print posted at ChemRxiv on 11 February 2019; doi:\u00a0<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv.7698185.v1\">https:\/\/doi.org\/10.26434\/chemrxiv.7698185.v1<\/a><\/li>\n<li>Listed amongst the top\u00a0<a href=\"https:\/\/www.journals.elsevier.com\/bioorganic-and-medicinal-chemistry\/most-downloaded-articles\">Most Downloaded Bioorganic &amp; Medicinal Chemistry Articles<\/a>\u00a0of the last 90 days (Apr 2019)<\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/02\/22\/crbn-versus-vhl\/\">here<\/a><\/li>\n<li>Our VHL ligand\u00a0<a href=\"https:\/\/www.tocris.com\/products\/vh-101-phenol_6952\">\u201cVH101, phenol\u201d<\/a>\u00a0functionalized for PROTAC conjugation is available from Tocris (January 2020)<\/li>\n<li>Our CRBN degrader\u00a0<a href=\"https:\/\/www.tocris.com\/products\/crbn-protac-14a_7219\">PROTAC 14a<\/a>\u00a0is available from Tocris (October 2020)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>75.<\/strong>\u00a0Popow, J., Arnhof, H., Bader, G., Berger, H., Ciulli, A., Covini, D., Dank, C., Gmaschitz, T., Greb, P., Karolyi-\u00d6zguer, J., Koegl, M., McConnell, D.B., Pearson, M., Rieger, M., Rinnenthal, J., Roessler, V., Schrenk, A., Spina, M., Steurer, S., Trainor, N., Traxler, E., Wieshofer, C., Zoephel, A., Ettmayer, P.<\/p>\n<p>Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.jmedchem.8b01826\"><em>J. Med. Chem.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>62 (5)<\/em>, 2508-2520<\/a><\/p>\n<ul>\n<li>PTK2 PROTACs\u00a0<a href=\"https:\/\/opnme.com\/molecules\/ptk2-protac-bi-0319\">BI-0319<\/a>\u00a0(VHL-based) and\u00a0<a href=\"https:\/\/opnme.com\/molecules\/ptk2-protac-bi-3663\">BI-3663<\/a>\u00a0(CRBN-based) are available for free from the OpnMe Portal.<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>74.<\/strong>\u00a0Roy, M.J., Winkler, S., Hughes, S.J., Whitworth, C., Galant, M., Farnaby, W., Rumpel, K., Ciulli, A.*<\/p>\n<p>SPR-measured dissociation kinetics of PROTAC ternary complexes influence target degradation rate<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acschembio.9b00092\"><em>ACS Chem. Biol.\u00a0<\/em><strong>2019<\/strong>,\u00a0<em>14 (3)<\/em>, 361-368<\/a><\/p>\n<ul>\n<li>Pre-print posted at bioRxiv 451948; 25 October 2018 doi:\u00a0<a href=\"https:\/\/doi.org\/10.1101\/451948\">https:\/\/doi.org\/10.1101\/451948<\/a><\/li>\n<li>Selected to be featured in\u00a0<a href=\"https:\/\/pubs.acs.org\/editorschoice\/\">ACS Editors\u2019 Choice<\/a>\u00a0based on recommendation by ACS journals\u2019 editors<\/li>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/05\/02\/our-new-paper-describing-an-spr-kinetic-assay-to-monitor-protac-ternary-complexes-is-now-out-in-acs-chemical-biology\/\">here<\/a><\/li>\n<li>Ranked Top amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=acbcct\">Most Read Articles<\/a>\u00a0in the journal (1-month timeframe, Mar-Apr 2019)<\/li>\n<li>Highlighted in Derek Lowe\u2019s blog\u00a0<a href=\"https:\/\/blogs.sciencemag.org\/pipeline\/archives\/2019\/03\/12\/what-those-degraders-are-actually-doing\">In the Pipeline<\/a><\/li>\n<li>Featured in Cytiva\u2019s\u00a0web article\/application note\u00a0<a href=\"https:\/\/www.cytivalifesciences.com\/en\/us\/solutions\/protein-research\/knowledge-center\/surface-plasmon-resonance\/characterizing-protac-ternary-complex-formation-using-biacore-spr-systems\">\u201cCharacterizing PROTAC ternary complex formation<\/a>\n<div><a href=\"https:\/\/www.cytivalifesciences.com\/en\/us\/solutions\/protein-research\/knowledge-center\/surface-plasmon-resonance\/characterizing-protac-ternary-complex-formation-using-biacore-spr-systems\">using Biacore\u2122 SPR systems\u201d<\/a><\/div>\n<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>73.<\/strong>\u00a0Frost, J., Ciulli, A.*, Rocha, S.*<\/p>\n<p>RNA-seq analysis of PHD and VHL inhibitors reveals differences and similarities to the hypoxia response.\u00a0[version 1; referees: 2 approved]<\/p>\n<p><em>Wellcome Open Res.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>4:17<\/em>\u00a0(<a href=\"https:\/\/doi.org\/10.12688\/wellcomeopenres.15044.1\">https:\/\/doi.org\/10.12688\/wellcomeopenres.15044.1<\/a>)<\/p>\n<p>\u00a0<\/p>\n<p><strong>72.<\/strong>\u00a0Castro, G.V, Ciulli, A.*<\/p>\n<p>Spy vs. spy: selecting the best reporter for 19F NMR competition experiments<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1039\/C8CC09790A\"><em>Chem. Commun.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>55 (10)<\/em>, 1482-1485<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2019\/01\/15\/vhl-ligands-as-spy-molecules-for-19f-nmr-screening\/\">here<\/a><\/li>\n<li>Our fluorinated VHL \u201cspy-molecule\u201d ligands are now available from the Merck Sigma-Aldrich catalogue:\u00a0<a href=\"https:\/\/www.sigmaaldrich.com\/catalog\/product\/aldrich\/909416?lang=en&amp;region=GB\">Fluorinated VHL spy molecule 1<\/a>,\u00a0<a href=\"https:\/\/www.sigmaaldrich.com\/catalog\/product\/aldrich\/909432?lang=en&amp;region=GB\">Fluorinated VHL Spy Molecule 2<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.sigmaaldrich.com\/catalog\/product\/aldrich\/909459?lang=en&amp;region=GB\">Fluorinated VHL Spy Molecule 4<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>71.<\/strong>\u00a0Zoppi, V., Hughes, S.J., Maniaci, C., Testa, A., Gmaschitz, T., Wieshofer, C., Koegl, M., Riching, K., Daniels, D.L., Spallarossa, A., and Ciulli, A.*<\/p>\n<p>Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7<\/p>\n<p><a href=\"http:\/\/pubs.acs.org\/doi\/10.1021\/acs.jmedchem.8b01413\"><em>J. Med. Chem.<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>62 (2)<\/em>, 699-726<\/a><\/p>\n<ul>\n<li>\n<div>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2018\/12\/12\/a-roadmap-for-protac-development\/\">here<\/a><\/div>\n<\/li>\n<li>\n<div>The coordinates and structure factors of the associated co-crystal structure of human BRD9 bromodomain in complex with PROTAC\u00a0<strong>5<\/strong>\u00a0is available in the PDB with accession code\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6HM0\">6HM0<\/a><\/div>\n<\/li>\n<li>\n<div>Listed as 1st\u00a0<a href=\"http:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Most Read Article<\/a>\u00a0in the journal (1-month timeframe, Jan 2019)<\/div>\n<\/li>\n<li>\n<div>Highlighted in the blog Promega Connection:\u00a0<a href=\"https:\/\/www.promegaconnections.com\/a-roadmap-for-protac-development\/\">\u201cA Roadmap for PROTAC Development\u201d<\/a><\/div>\n<\/li>\n<li>\n<div>Find out more about VZ185 in the\u00a0<a href=\"https:\/\/www.chemicalprobes.org\/vz185\">Chemical Probes Portal<\/a><\/div>\n<\/li>\n<li>\n<div>Our dual Brd7\/9 degrader\u00a0<a href=\"https:\/\/www.tocris.com\/products\/vz-185_6936\">VZ185<\/a>\u00a0is available from Tocris (October 2019)<\/div>\n<\/li>\n<li>The inactive epimer\u00a0<a href=\"https:\/\/www.tocris.com\/products\/cis-vz-185_6939\">cis-VZ185<\/a>\u00a0is also available from Tocris (April 2020)<\/li>\n<li>The PROTAC <a href=\"https:\/\/www.opnme.com\/molecules\/brd9-vz185\">VZ185<\/a> (together with its negative control cis-VZ185) are also available from Boehringer Ingelheim\u2019s OpnMe Portal: order for free, no strings attached!<\/li>\n<li>\n<div>Our VHL ligand\u00a0<a href=\"https:\/\/www.tocris.com\/products\/vh-101-phenol_6952\">\u201cVH101, phenol\u201d<\/a>\u00a0functionalized for PROTAC conjugation is available from Tocris (January 2020)<\/div>\n<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>70.<\/strong>\u00a0Aresu, L., Ferraresso, S., Marconato, L., Cascione, L., Napoli, S., Gaudio, E., Kwee, I., Tarantelli, C., Testa, A., Maniaci, C., Ciulli, A., Hillmann, P., Bohnacker, T., Wymann, M.P., Comazzi, S., Milan, M., Riondato, F., Dalla Rovere, G., Giantin, M., Giannuzzi, D., Bertoni, F.<\/p>\n<p>New Molecular And Therapeutic Insights Into Canine Diffuse Large B Cell Lymphoma Elucidates The Role Of The Dog As A Model For Human Disease<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.3324\/haematol.2018.207027\"><em>Haematologica<\/em>\u00a0<strong>2019<\/strong>,\u00a0<em>104 (6)<\/em>, e256-e259<\/a><\/p>\n<p>\u00a0<\/p>\n<h3><strong>2018<\/strong><\/h3>\n<p>\u00a0<\/p>\n<p><strong>69.<\/strong>\u00a0Lucas, X., Van Molle, I., Ciulli, A.*<\/p>\n<p>Surface probing by fragment-based screening and computational methods identifies ligandable pockets on the von Hippel-Lindau (VHL) E3 ubiquitin ligase<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.jmedchem.8b00842\"><em>J. Med. Chem.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>61 (16)<\/em>, 7387-7393<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2018\/07\/24\/two-ligandable-pockets-on-the-surface-of-the-vhl-e3-ligase\/\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the PDB. Accession codes of VCB (pVHL:ElonginC:ElonginB complex) in complex with MB235 (PDB\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6GMN\">6GMN<\/a>), MB756 (PDB\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6GMQ\">6GMQ<\/a>), MB1200 (PDB\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6GMX\">6GMX<\/a>), and VCBH (pVHL:ElonginC:ElonginB:HIF-1alpha complex) in complex with MB756 (PDB\u00a0<a href=\"http:\/\/www.rcsb.org\/structure\/6GMR\">6GMR<\/a>)<\/li>\n<li>Listed amongst the\u00a0<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?journalCode=jmcmar\">Most Read Articles<\/a>\u00a0in the journal (Aug 2018)<\/li>\n<li>Highlighted in the Faculty of 1000 Prime\u00a0<a href=\"https:\/\/f1000.com\/prime\/733788755\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" id=\"bg\" src=\"https:\/\/cdn.f1000.com.s3.amazonaws.com\/images\/badges\/badgef1000.gif\" alt=\"Access the recommendation on F1000Prime\"><\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>68.<\/strong>\u00a0Testa, A., Lucas, X., Castro, G.V., Chan, K.-H., Wright, J.E., Runcie, A.C., Gadd, M.S., Harrison, W.T.A., Ko, E.-J., Fletcher, D., Ciulli, A.*<\/p>\n<p>3-Fluoro-4-hydroxyprolines: Synthesis, conformational analysis and stereoselective recognition by the VHL E3 ubiquitin ligase for targeted protein degradation<\/p>\n<p><a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.8b05807\"><em>J. Am. Chem. Soc.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>140 (29)<\/em>, 9299-9313<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2018\/06\/27\/introducing-3-fluoro-4-hydroxyprolines\/\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the PDB, with accession codes:\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/search\/structidSearch.do?structureId=6GFX\">6GFX<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/search\/structidSearch.do?structureId=6GFY\">6GFY<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.rcsb.org\/pdb\/search\/structidSearch.do?structureId=6GFZ\">6GFZ<\/a><\/li>\n<li>Addition\/Correction published (Web): April 24, 2019. DOI:\u00a0<a href=\"http:\/\/dx.doi.org\/10.1021\/jacs.9b03833\">10.1021\/jacs.9b03833<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>67.<\/strong>\u00a0Soares, P., Lucas, X., Ciulli, A.*<\/p>\n<p>Thioamide substitution to probe the hydroxyproline recognition of VHL ligands<\/p>\n<p><a href=\"http:\/\/doi.org\/10.1016\/j.bmc.2018.03.034\"><em>Bioorg. Med. Chem.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>26 (11)<\/em>, 2992-2995<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/new-paper-thioamide-substitution-probe-hydroxyproline-recognition-vhl-ligands-published-bioorg\">here<\/a><\/li>\n<li>The article is a contribution to the journal\u2019s\u00a0<a href=\"https:\/\/www.sciencedirect.com\/journal\/bioorganic-and-medicinal-chemistry\/vol\/26\/issue\/11\">Special Issue<\/a>\u00a0for the 2018 Tetrahedron Young Investigators Award for Matthew Fuchter<\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the Protein DataBank, with accession codes:\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6fmi\">6FMI<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FMJ\">6FMJ<\/a>, and\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FMK\">6FMK<\/a><\/li>\n<li>4th\u00a0<a href=\"https:\/\/www.journals.elsevier.com\/bioorganic-and-medicinal-chemistry\/most-downloaded-articles\">Most Downloaded Article<\/a>\u00a0in the journal (June 2018)<\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>66.<\/strong>\u00a0Amato, A., Lucas, X., Bortoluzzi, A., Wright, D., Ciulli, A.*<\/p>\n<p>Targeting ligandable pockets on plant homeodomain (PHD) zinc finger domains by a fragment-based approach<\/p>\n<p><a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acschembio.7b01093\"><em>ACS Chem. Biol.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>13 (4)<\/em>, 915-921<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/our-paper-probing-ligandability-phd-finger-domains-baz2a-and-baz2b-fragment-screening-now\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the Protein DataBank, with accession codes:\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FHU\">6FHU<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FKP\">6FKP<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FI0\">6FI0<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FAP\">6FAP<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FHQ\">6FHQ<\/a>, and\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/6FI1\">6FI1<\/a><\/li>\n<\/ul>\n<p>\u00a0<\/p>\n<p><strong>65.<\/strong>\u00a0Runcie, A.C., Zengerle, M., Chan, K.-H., Testa, A., van Beurden, L., Baud, M.G.J., Epemolu, O., Ellis, L.C.J., Read, K.D., Coulthard, V., Brien, A. and Ciulli, A.*<\/p>\n<p>Optimization of a \u201cbump-and-hole\u201d approach to allele-selective BET bromodomain inhibition<\/p>\n<p><a href=\"http:\/\/www.dx.doi.org\/10.1039\/C7SC02536J\"><em>Chem. Sci.<\/em>\u00a0<strong>2018<\/strong>,\u00a0<em>9<\/em>, 2452-2468<\/a><\/p>\n<ul>\n<li>See Figures\u00a0<a href=\"http:\/\/www.lifesci.dundee.ac.uk\/groups\/alessio-ciulli\/\/news\/new-paper-refinement-%E2%80%9Cbump-and-hole%E2%80%9D-approach-allele-selective-bet-bromodomain-inhibition-now\">here<\/a><\/li>\n<li>The coordinates and structure factors of our co-crystal structures are available in the Protein DataBank, with accession codes:\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O39\">5O39<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3A\">5O3A<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3B\">5O3B<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3C\">5O3C<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3D\">5O3D<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3E\">5O3E<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3F\">5O3F<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3G\">5O3G<\/a>,\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3H\">5O3H<\/a>\u00a0and\u00a0<a href=\"https:\/\/www.rcsb.org\/structure\/5O3I\">5O3I<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>2021 \u00a0 109.\u00a0Tarantelli, C., Cannas, E., Ekeh, H., Moscatello, C., Gaudio, E., Cascione, L., Napoli, S., Rech, C., Testa, A., Maniaci, C., Rinaldi, A., Zucca, E., Stathis, A., Ciulli, A., Bertoni, F. The bromodomain and extra-terminal domain degrader MZ1 exhibits preclinical anti-tumoral activity in diffuse large B-cell lymphoma of the activated B cell-like type Explor. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":168,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4117","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/4117","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=4117"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/4117\/revisions"}],"predecessor-version":[{"id":4640,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/4117\/revisions\/4640"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=4117"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}