{"id":3335,"date":"2024-07-15T10:00:18","date_gmt":"2024-07-15T09:00:18","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=3335"},"modified":"2026-01-26T14:32:57","modified_gmt":"2026-01-26T14:32:57","slug":"koodac-team","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/group\/koodac-team\/","title":{"rendered":"KOODAC Team – Knocking Out Oncogenic Drivers And Curing Childhood Cancer"},"content":{"rendered":"

KOODAC \u2013 Knocking Out Oncogenic Drivers And Curing Childhood Cancer<\/h2>\n

The KOODAC team was established in 2024 as part of Cancer Grand Challenges. We are a multidisciplinary, international team focussed on the development of degrader drugs for childhood cancers, bringing together scientists, clinicians and patient advocates with a wealth of expertise in childhood cancers and drug discovery. We investigate five oncoproteins known to drive high-risk paediatric cancers that currently have no safe, effective treatments. Degrader drugs offer a new opportunity to target these oncoproteins with improved potency and selectivity. In Dundee, developing new PROTAC degraders for these targets requires solving X-ray crystal structures for rational design, establishing plate-based synthetic chemistry methods, developing biophysical and biochemical methods to assess PROTAC binding and working closely with our collaborators with the aim of delivering first-in-child phase 1 clinical studies for the treatment of cancer.<\/p>\n

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\"Roberta
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Person<\/p>\n

Roberta Ibba<\/a><\/div>\n

Scientist Medicinal Chemistry \/ Chemical Biology<\/p>\n<\/p><\/div>\n<\/article>\n

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\"Alena
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Person<\/p>\n

Alena Kroupova<\/a><\/div>\n

Scientist Structural Biology<\/p>\n<\/p><\/div>\n<\/article>\n

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Person<\/p>\n

Michael Krummhaar<\/a><\/div>\n

Scientist Structural Biology<\/p>\n<\/p><\/div>\n<\/article>\n

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\"Liam
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<\/a>
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Person<\/p>\n

Liam Martin<\/a><\/div>\n

Scientist Medicinal \/ Organic Chemistry<\/p>\n<\/p><\/div>\n<\/article>\n

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\"Suzanne
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<\/a>
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Person<\/p>\n

Suzanne O’Connor<\/a><\/div>\n

Team Leader, Medicinal \/ Organic Chemistry<\/p>\n<\/p><\/div>\n<\/article>\n

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<\/a>
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Person<\/p>\n

Alexandra Teslenko<\/a><\/div>\n

Scientist Biophysics \/ Chemical and Structural Biology<\/p>\n<\/p><\/div>\n<\/article><\/div>\n","protected":false},"excerpt":{"rendered":"

KOODAC \u2013 Knocking Out Oncogenic Drivers And Curing Childhood Cancer The KOODAC team was established in 2024 as part of Cancer Grand Challenges. We are a multidisciplinary, international team focussed on the development of degrader drugs for childhood cancers, bringing together scientists, clinicians and patient advocates with a wealth of expertise in childhood cancers and […]<\/p>\n","protected":false},"author":789,"featured_media":3807,"parent":188,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-3335","page","type-page","status-publish","has-post-thumbnail","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/3335","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/789"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=3335"}],"version-history":[{"count":1,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/3335\/revisions"}],"predecessor-version":[{"id":4625,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/3335\/revisions\/4625"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media\/3807"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=3335"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}