{"id":168,"date":"2023-10-27T15:32:42","date_gmt":"2023-10-27T14:32:42","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=168"},"modified":"2026-03-18T22:47:21","modified_gmt":"2026-03-18T22:47:21","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">PubMed Link<\/h2>\n\n\n\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/entrez?cmd=search&amp;db=pubmed&amp;term=%28Ciulli%20A%5bAU%5d%29%20AND%20%28%222002%22%5bPublication%20Date%5d%20:%20%223000%22%5bPublication%20Date%5d%29\">PubMed list of publications<\/a><\/p>\n\n\n\n<div>\n<h2>Google Scholar Link<\/h2>\n<p><a href=\"https:\/\/scholar.google.co.uk\/citations?user=yTciKqYAAAAJ&amp;hl=en&amp;oi=ao\">Google Scholar Profile<\/a><\/p>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Previous Publications<\/h2>\n\n\n\n<p><b><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/2018-2\/\">2018-2021<\/a><\/b><\/p>\n\n\n\n<p><b><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/2017-2011\/\">2011-2017<\/a><b><\/b><\/b><\/p>\n\n\n\n<div class=\"wp-block-blocksy-child-accordion\"><div class=\"accordion-controls\"><button class=\"accordion-open-all\" aria-expanded=\"false\">Open all <span class=\"visually-hidden\" aria-expanded=\"false\">sections<\/span><\/button><\/div>\n<div class=\"wp-block-blocksy-child-accordion-item\"><div class=\"accordion-header\"><button class=\"accordion-button\" aria-controls=\"content-accordion-dc248916-87a3-4292-9638-8d54ebe01e70\" id=\"button-accordion-dc248916-87a3-4292-9638-8d54ebe01e70\"><span class=\"accordion-title extra\">Preprints &#8211; *Corresponding author<\/span><\/button><\/div><div class=\"accordion-content\" id=\"content-accordion-dc248916-87a3-4292-9638-8d54ebe01e70\" aria-hidden=\"true\" aria-labelledby=\"button-accordion-dc248916-87a3-4292-9638-8d54ebe01e70\">\n<ul class=\"wp-block-list\">\n<li>Sarah F. Chandler, Michael H. Tatham, Emma Branigan, Mark A. Nakasone, Nikolai Makukhin, Alessio Ciulli, Ronald T. Hay. Photocrosslinking Activity-Based Probes to Capture the Dynamics of Ubiquitin RING E3 Ligase Interactions. bioRxiv 2026.03.13.711684; doi: <a href=\"https:\/\/doi.org\/10.64898\/2026.03.13.711684\">https:\/\/doi.org\/10.64898\/2026.03.13.711684<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Regina Baur, Laura Anna Schneider, Gajanan Sathe, Thomas Lunardi, Jonathan Schneider, Anna-Sophia Krebs, Juan Carlos Silva, Diane Laure Haakonsen, Sebastian Martin Waszak, Joachim Lingner, Alessio Ciulli, Michael Rape, Nicolas H Th\u00f6ma. Medulloblastoma-Associated KBTBD4 Mutations Disrupt PP2A-A Orphan Quality Control. bioRxiv 2026.03.02.709011; doi: <a href=\"https:\/\/doi.org\/10.64898\/2026.03.02.709011\">https:\/\/doi.org\/10.64898\/2026.03.02.709011<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Suzanne O\u2019Connor, Zoe Rutter, Angus Cowan, Markus Zeeb, Florian Binder, Yuting Cao, Sohini Chakraborti, Stefan Djukic, Leonhard Geist, Elizabeth Hogg, Giorgia Kidd, Matthias Krumb, Simon Langer, Denis Schmidt, Liam Martin, Elisha McCrory, Giacomo Padroni, Ilaria Puoti, Luke Simpson, Manon Sturbaut, Lisa Crozier, Vesna Vetma, Qingzhi Zhang, Kirsten McAulay,* Theodor Theis,*&nbsp;Alessio Ciulli.* Tuning the open-close equilibrium of Cereblon with small molecules influences protein degradation. bioRxiv 2025.12.19.695617; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.64898\/2025.12.19.695617\">https:\/\/doi.org\/10.64898\/2025.12.19.695617<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Louise Sternicki, Charlotte Crowe,&nbsp;Alessio Ciulli, Sally-Ann Poulsen.&nbsp;Native Mass Spectrometry Analysis of a Cullin RING Ubiquitin E3 Ligase Complex in the Context of Targeted Protein Degradation. bioRxiv 2025.12.04.692288; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.64898\/2025.12.04.692288\">https:\/\/doi.org\/10.64898\/2025.12.04.692288<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Charlotte Crowe, Alessandra Salerno, Gajanan Sathe, Graham Marsh, Hannah Maple,&nbsp;Alessio Ciulli.* Linker-rigidified VHL homodimerizers convert degraders into stabilizers of non-ubiquitinable ternary complexes. bioRxiv 2025.11.18.689129; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2025.11.18.689129\">https:\/\/doi.org\/10.1101\/2025.11.18.689129<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Carlo J. A. Verhoef, Charlotte Crowe, Mark A. Nakasone, Aitana DeLaCuadra-Bast\u00e9, Tessa Harzing, Naomi A. S. Span, Gajanan Sathe, Kentaro Iso, Christian Ottmann, Luc Brunsveld,&nbsp;Alessio Ciulli,* Peter J. Cossar.* Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design. bioRxiv 2025.11.17.688825; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2025.11.17.688825\">https:\/\/doi.org\/10.1101\/2025.11.17.688825<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dylan E. Ramage, Lianne H.E. Wieske, Charlotte Crowe, Jens B. Christensen, Theo A. von Wilmowski, Drew W. Grant, Zoe Bannister, Mark A. Nakasone, Kevin Haubrich, Mark Dorward, Iva A. Tchasovnikarova, Michael P. Weekes, N. Sumru Bayin,&nbsp;Alessio Ciulli, Richard T. Timms. LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance. bioRxiv 2025.09.23.678073; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2025.09.23.678073\">https:\/\/doi.org\/10.1101\/2025.09.23.678073<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Valentina A. Spiteri, Dmitri Segal, Alejandro Correa-S\u00e1ez, Kentaro Iso, Ryan Casement, Miquel Mu\u00f1oz i Ordo\u00f1o, Mark A. Nakasone, Gajanan Sathe, Caroline Sch\u00e4tz, Hannah E. Peters, Mark Doward, Lisa Kainacher, Angus D. Cowan,&nbsp;Alessio Ciulli*, Georg E. Winter.* Dual E3 ligase recruitment by monovalent degraders enables redundant and tuneable degradation of SMARCA2\/4. bioRxiv 2025.08.04.668513; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2025.08.04.668513\">https:\/\/doi.org\/10.1101\/2025.08.04.668513<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Maria Rodriguez-Rios, Conner Craigon, Mark A. Nakasone, Adam G. Bond, Mark Dorward, Anthony K. Edmonds, Mark C. Norley, Robert E. Arnold, Paul M. Wood, Stephen J. Reynolds, Joel O. Cresser-Brown, Graham P. Marsh, Hannah J. Maple,&nbsp;Alessio Ciulli*. BromoCatch: a self-labelling tag platform for protein analysis and live cell imaging. bioRxiv 2025.04.07.647551; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2025.04.07.647551\">https:\/\/doi.org\/10.1101\/2025.04.07.647551<\/a><\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Lan, H., Hsia, O., Nakasone, M., Wijaya, A.,&nbsp;Ciulli, A.*, Butts, C.*, Aggarwal, V.* Computation, Synthesis and NMR Investigations of PROTAC Linker Conformation, Chamaleonicity and their Impacts on the Mode of Action. ChemRxiv. 2024; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2024-5dbnb\">10.26434\/chemrxiv-2024-5dbnb<\/a>. This content is a preprint and has not been peer-reviewed.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ponzo, I., Solda, A., Crowe, C., Dahl, G., Geschwindner, S.*,&nbsp;Ciulli, A.*, Rant, U.* Proximity Biosensor Assay for PROTAC Ternary Complex Analysis. ChemRxiv. 2024; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2024-8w4zb\">10.26434\/chemrxiv-2024-8w4zb<\/a>. This content is a preprint and has not been peer-reviewed.<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Peer-reviewed, published articles<\/strong><\/h2>\n\n\n\n<p>*Corresponding Author<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2026<\/strong><\/h3>\n\n\n\n<p><strong>160.<\/strong> Cowan, A.D.,* Jaekel, S.,&nbsp;Ciulli, A..* <\/p>\n\n\n\n<p>Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors.<\/p>\n\n\n\n<p><em>Protein Expression and Purification.<\/em> Available online 4 March 2026, Doi: <a href=\"https:\/\/doi.org\/10.1016\/j.pep.2026.106907\" data-type=\"link\" data-id=\"https:\/\/doi.org\/10.1016\/j.pep.2026.106907\">10.1016\/j.pep.2026.106907<\/a><\/p>\n\n\n\n<p><strong>159.<\/strong> Shaum, J.B., Mu\u00f1oz, I. Ordo\u00f1o M., Steen, E.A., Wenge, D.V., Cheong, H., Janowski, J., Hunkeler, M., Bilotta, E.M., Rutter, Z.J., Barta, P.A., Thornhill, A.M., Milosevich, N., Hargis, L.M., Bishop, T.R., Carter, T.R., da Camara, B., Hinterndorfer, M., Dada, L., He, W.J., Offensperger, F., Furihata, H., Schweber, S.R., Hatton, C., Wen, Y., Cravatt, B.F., Engle, K.M., Donovan, K.A., Melillo, B., Kitamura, S., Ciulli, A., Armstrong, S.A., Fischer, E.S., Winter, G.E., Erb, M.A. <\/p>\n\n\n\n<p>High-throughput ligand diversification to discover chemical inducers of proximity.<\/p>\n\n\n\n<p><em>Nat Chem Biol.<\/em> <strong>2026<\/strong> Feb 16. doi: <a href=\"https:\/\/doi.org\/10.1038\/s41589-025-02137-2\" data-type=\"link\" data-id=\"https:\/\/doi.org\/10.1038\/s41589-025-02137-2\">10.1038\/s41589-025-02137-2<\/a>. Epub ahead of print.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41699285\/\">41699285<\/a>.<\/li>\n<\/ul>\n\n\n\n<p><strong>158.<\/strong> Frost, A., O\u2019Connor, S., Ciulli, A.*<\/p>\n\n\n\n<p>Allosteric PROTACs: Expanding the Horizon of Targeted Protein Degradation.<\/p>\n\n\n\n<p><em>J Am Chem Soc.<\/em> <strong>2026<\/strong> Jan 13. doi: <a href=\"https:\/\/doi.org\/10.1021\/jacs.5c14840\">10.1021\/jacs.5c14840<\/a>. Epub ahead of print.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41530095\/\">41530095<\/a>.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2025<\/strong><\/h3>\n\n\n\n<p><strong>157.<\/strong> Cao, Y., Harris, A.L., Ciulli, A.*<\/p>\n\n\n\n<p>Branching beyond bifunctional linkers: synthesis of macrocyclic and trivalent PROTACs.<\/p>\n\n\n\n<p><em>Nat Protoc.<\/em> <strong>2025<\/strong> Nov 11. doi: <a href=\"https:\/\/doi.org\/10.1038\/s41596-025-01283-0\">10.1038\/s41596-025-01283-0<\/a>. Epub ahead of print.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41219525\/\">41219525<\/a>.<\/li>\n\n\n\n<li>Featured in <a href=\"https:\/\/scienmag.com\/advancing-protacs-new-macrocyclic-and-trivalent-designs\/\">sciencemag.com<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>156.<\/strong> Vetma, V., Puoti, I., Karolak, N.K., Chakraborti, S., Diers, E., Girardi, E., Khan, S., Kidd, G., Kropatsch, K.G., Mclennan, R., O\u2019Connor, S., Samwer, M., Trainor, N., Whitworth, C., Wijaya, A.J., Wong, J.Y.F., Zollman, D., Farnaby, W., Popow, J., Ciulli, A.*, Ettmayer, P.*, McAulay, K.*<\/p>\n\n\n\n<p>Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/jacs.5c10354\"><em>J Am Chem Soc.<\/em> <strong>2025<\/strong>, Nov 12;147(45):41367-41378.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41166656\/\">41166656<\/a>.<\/li>\n\n\n\n<li>Pre-print first posted at ChemRxiv on 17 June 2025; doi: <a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2025-706mw\">10.26434\/chemrxiv-2025-706mw<\/a>.<\/li>\n\n\n\n<li>X-ray crystallography data generated in this study have been deposited in the Protein Data Bank (PDB) under accession codes: <a href=\"https:\/\/www.rcsb.org\/structure\/9RK8\">9RK8<\/a> (compound <strong>3<\/strong> in complex with VCB (pVHL:ElonginC:ElonginB) and KRAS G12V GDP), <a href=\"https:\/\/www.rcsb.org\/structure\/9RKC\">9RKC<\/a> (ACBI4 in complex with VCB (pVHL:ElonginC:ElonginB) and KRAS G12D GDP), <a href=\"https:\/\/www.rcsb.org\/structure\/9RKE\">9RKE<\/a> (compound <strong>1<\/strong> in complex with KRAS G12R GCP and VCB), <a href=\"https:\/\/www.rcsb.org\/structure\/9RKJ\">9RKJ<\/a> (compound <strong>3<\/strong> in complex with KRAS G12R GCP and VCB), and <a href=\"https:\/\/www.rcsb.org\/structure\/9RKN\">9RKN<\/a> (ACBI4 in complex with KRAS G12R GCP and VCB).<\/li>\n<\/ul>\n\n\n\n<p><strong>155.<\/strong> Hughes, S.J., Stec, W.J., Davies, C.T.R., McGarry, D., Williams, A., Carrara, M., Del Barco Barrantes, I., Harris, R., Tasegian, A., Owens, D.D.G., Fawcett, A., Hellicar, J., Azevedo, A., Meier, G.P., Runcie, A.C., Greger, L., O\u2019Rourke, M., Churcher, I., Pass, M., Brown, G.A., Ciulli, A., Modis, L.K., Testa, A.<\/p>\n\n\n\n<p>Mode of action of a DCAF16-recruiting targeted glue that can selectively degrade BRD9.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-63594-w\"><em>Nat. Commun.<\/em> <strong>2025<\/strong> Oct 27; 16(1):8516.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41145412\/\">41145412<\/a>.<\/li>\n\n\n\n<li>Pre-print first posted at BioRxiv on 31 December 2024; doi: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.12.31.630899v1\">10.1101\/2024.12.31.630899<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>154.<\/strong> Ma, N., Bhattacharya, S., Muk, S., Jandova, Z., Schmalhorst, P.S., Ghosh, S., Le, K., Diers, E., Trainor, N., Farnaby, W., Roy, M.J., Kofink, C., Greb, P., Weinstabl, H., Ciulli, A., Bader, G., Sankar, K., Bergner, A., Vaidehi, N.<\/p>\n\n\n\n<p>Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-63713-7\"><em>Nat. Commun.<\/em> <strong>2025<\/strong> Sep 29; 16(1):8595.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/41022846\/\">41022846<\/a>.<\/li>\n<\/ul>\n\n\n\n<p><strong>153.<\/strong> Dikic, I., Mayor-Ruiz, C., Winter, G.E., Koch, K., Ciulli, A.*, Thom\u00e4, N.H.<\/p>\n\n\n\n<p>Opportunities in proximity modulation: Bridging academia and industry.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.molcel.2025.07.018\"><em>Mol. Cell.<\/em> <strong>2025<\/strong> Aug 21; 85(16):3012-3022.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40845803\/\">40845803<\/a>.<\/li>\n<\/ul>\n\n\n\n<p><strong>152.<\/strong> Lloyd, H.C., Li, Y., Payne, N.C., Zhao, Z., Xu, W., Kroupova, A., Zollman, D., Long, T., Kabir, F., Chen, M., Freeman, R., Feng, E.Y., Xi, S.Y., Hsu, Y.C., Ciulli, A., Mazitschek, R., Woo, C.M.<\/p>\n\n\n\n<p>A method for the detection and enrichment of endogenous cereblon substrates.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.chembiol.2025.07.002\"><em>Cell Chem. Biol.<\/em> <strong>2025<\/strong> Aug 21; 32(8):1028-1041.e13.&nbsp;<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40782806\/\">40782806<\/a>.<\/li>\n\n\n\n<li>Pre-print first posted at BioRxiv on 26 March 2025; doi: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2025.03.24.645063v1\">10.1101\/2025.03.24.645063<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>151.<\/strong> Hinterndorfer, M., Spiteri, V.A., Ciulli, A.*, Winter, G.E.*<\/p>\n\n\n\n<p>Targeted protein degradation for cancer therapy.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41568-025-00817-8\"><em>Nat. Rev. Cancer.<\/em> <strong>2025<\/strong> Jul; 25(7):493-516.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40281114\/\">40281114<\/a>.<\/li>\n<\/ul>\n\n\n\n<p><strong>150.<\/strong> Vetma, V., O\u2019Connor, S., Ciulli, A.*<\/p>\n\n\n\n<p>Development of PROTAC degrader drugs for cancer<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1146\/annurev-cancerbio-061824-105806\"><em>Annu. Rev. Cancer Biol. <\/em><strong>2025<\/strong> Apr; 9:119-140.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Review in Advance, 30 Oct 2024<\/li>\n<\/ul>\n\n\n\n<p><strong>149.<\/strong> Salerno, A., Wieske, L.H.E., Diehl, C.J., Ciulli, A.*<\/p>\n\n\n\n<p>Rational Design of PROTAC Linkers Featuring Ferrocene as a Molecular Hinge to Enable Dynamic Conformational Changes.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/jacs.4c18354\"><em>J Am Chem Soc.<\/em> <strong>2025<\/strong>&nbsp;Apr 23;147(16):13328-13344.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40208910\/\">40208910<\/a> PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12022980\/\">PMC12022980<\/a>.<\/li>\n\n\n\n<li>Pre-print first posted at ChemRxiv on 21 December 2025; doi: <a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2024-1lm1h\">10.26434\/chemrxiv-2024-1lm1h<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>148.<\/strong> Usart, M., Kimmerlin, Q., Stetka, J., Stoll, C., Rai, S., Almeida Fonseca, T., Karjalainen, R., Hao-Shen, H., Roux, J., El Taher, A., Lynch, D., Makukhin, N., Ciulli, A., Skoda, R.C.<\/p>\n\n\n\n<p>Loss of Socs2 improves molecular responses to IFN\u03b1 in a mouse model of myeloproliferative neoplasms driven by JAK2-V617F.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41375-025-02550-5\"><em>Leukemia<\/em>. <strong>2025<\/strong> Apr;39(4):876-887. <\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40069287\/\">40069287<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>147. <\/strong>Newton, L.S., Gathmann, C., Ridewood, S., Smith, R.J., Wijaya, A.J., Hornsby, T.W., Morling, K.L., Annett, D., Chiozzi, R.Z., Reuschl, A.K., Govasli, M.L., Tan, Y.Y., Thorne, L.G., Jolly, C., Thalassinos, K., Ciulli, A., Towers, G.J., Selwood, D.L.<\/p>\n\n\n\n<p>Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-025-56317-8\"><em>Nat. Commun.<\/em> <strong>2025<\/strong> Feb 10;16(1):1484.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39929804\/\">39929804<\/a> PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11811207\/\">PMC11811207<\/a><\/li>\n\n\n\n<li>Pre-print first posted at Research Square on 15 March 2023; DOI: <a href=\"https:\/\/doi.org\/10.21203\/rs.3.rs-2639894\/v1\">10.21203\/rs.3.rs-2639894\/v1<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>146.<\/strong> McGown, A., Vetma, V., Crepin, D., Lin, Y., Adcock, C., Craigon, C., Nafie, J., von Emloh, D., Sutton, L., Bailey, K., Edmunds, L., Sharma, M., Wilden, J.D., Coles, S.J., Tizzard, G.J., Farnaby, W., Ciulli, A., Kostakis, G.E., Spencer, J.<\/p>\n\n\n\n<p>Use of Aldehyde\u2013Alkyne\u2013Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acsmedchemlett.4c00531\"><em>ACS Med. Chem. Lett.<\/em> <strong>2025<\/strong> Jan 25;16(2):278-284.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39967623\/\">39967623<\/a> PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11831382\/\">PMC11831382<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>145.<\/strong> Urbina, A., Hallatt, A.J., Robertson, J., Ciulli, A.*<\/p>\n\n\n\n<p>A patent review of von Hippel-Lindau (vhl)-recruiting chemical matter: E3 ligase ligands for PROTACs and targeted protein degradation (2019-present)<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1080\/13543776.2024.2446232\"><em>Expert Opin. Ther. Pat.<\/em> <strong>2025<\/strong> Feb 6:1-42.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39834300\/\">39834300<\/a><\/li>\n\n\n\n<li>Listed as <a href=\"https:\/\/www.tandfonline.com\/journals\/ietp20\">1st Most Read<\/a> Article in the journal (Feb 2025)<\/li>\n<\/ul>\n\n\n\n<p><strong>144.<\/strong> Wolf, G., Craigon, C., Teoh, S.T., Essletzbichler, P., Onstein, S., Cassidy, D., Uijttewaal, E.C.H., Dvorak, V., Cao, Y., Bensimon, A., Elling, U., Ciulli, A., Superti-Furga, G.<\/p>\n\n\n\n<p>The efflux pump ABCC1\/MRP1 constitutively restricts PROTAC sensitivity in cancer cells<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.chembiol.2024.11.009\"><em>Cell Chem. Biol.<\/em> <strong>2025<\/strong>&nbsp;Feb 20;32(2):291-306.e6.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39755121\/\">39755121<\/a><\/span><\/span><\/li>\n<\/ul>\n\n\n\n<p><strong>143.<\/strong> Alkhalaf, L.M., Arrowsmith, C., Balskus, E.P., Bergamini, G., Bhandari, R., Chang, C.J., Chen, P., Chen, X., Ciulli, A., Cricco, J.A., Davis, B.G., Delbianco, M., Dudareva, N., Dueber, E., Ferguson, F., de Giuseppe, P.O., Hamachi, I., Hammond, M.C., Hatzios, S.K., Do Heo, W., Janet, J.P., Kamat, S.S., Knapp, S., Krishnan, Y., Lang, K., Laraia, L., Leveson-Gower, R.B., Li, X.D., Liu, D.R., Liu, M.F., London, N., Mahanta, N., Mayor-Ruiz, C., Muir, T., Murakami, M.T., Rhee, H.W., Robers, M., Satz, A., Schulman, B.A., Shen, B., Shoichet, B., Strauss, E., Suzuki, T., Tiwary, P., Waldmann, H., Ward, T.R., Weeks, A., Weerapana, E., Winter, G.<\/p>\n\n\n\n<p>Thoughts for the future<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41589-024-01802-2\"><em>Nat. Chem. Biol.<\/em> <strong>2025<\/strong> Jan;<em>21(1)<\/em>:6-15.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39719500\/\">39719500<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2024<\/strong><\/h3>\n\n\n\n<p><strong>142.<\/strong> Lynch, D.M., Forrester, B., Webb, T., Ciulli, A.*<\/p>\n\n\n\n<p>Unravelling the druggability and immunological roles of the SOCS-family proteins<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.3389\/fimmu.2024.1449397\"><em>Front. Immunol. <\/em><strong>2024<\/strong> Nov 29;<em>15<\/em>:1449397.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39676878\/\">39676878<\/a>&nbsp; <\/span><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:&nbsp;<\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11638205\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11638205<\/a><\/span><\/li>\n<\/ul>\n\n\n\n<p><strong>141.<\/strong> Tredup, C.; Ackloo, S.; Beck, H.; Brown, P.; Bullock, A.; Ciulli, A.; Dikic, I.; Edfeldt, K.; Edwards, A.; Elkins, J.; Farin, H.; Fon, E.A.; Gstaiger, M.; G\u00fcnther, J.; Gustavsson, A.-L.; H\u00e4berle, S.; Isigkeit, L.; Huber, K.; Kotschy, A.; Kr\u00e4mer, O.; Leach, A.R. ; Marsden, B.; Matsui, H.; Merk, D.; Montel, F.; Mulder, M.; M\u00fcller, S.; Owen, D.; Proschak, E.; R\u00f6hm, S.; Stolz, A.; Sundstr\u00f6m, M.; von Delft, F.; Willson, T.; Arrowsmith, C.H.; Knapp, S.<\/p>\n\n\n\n<p>Toward Target 2035: EUbOPEN \u2013 a public-private partnership to enable &amp; unlock biology in the open<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1039\/d4md00735b\"><em>RSC Med. Chem.<\/em> <strong>2024<\/strong> Nov 29;16(2):457-464.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39618964\/\">39618964<\/a>&nbsp; <\/span><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:&nbsp;<\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11605244\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11605244<\/a><\/span><\/li>\n<\/ul>\n\n\n\n<p><strong>140.<\/strong> Bond, A. G.; Mu\u00f1oz i Ordo\u00f1o, M.; Bisbach, C. M.; Craigon, C.; Makukhin, N.; Caine, E. A.; Nagala, M.; Urh, M.; Winter, G. E.;* Riching, K. M.;* Ciulli, A.*<\/p>\n\n\n\n<p>Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/jacs.4c11556\"><em>J. Am. Chem. Soc.<\/em> <strong>2024<\/strong> Dec 11;<em>146(49)<\/em>:33675-33711. <\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39606859\/\">39606859<\/a>&nbsp; <\/span><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:&nbsp;<\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11638965\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11638965<\/a><\/span><\/li>\n\n\n\n<li>Pre-print first posted at ChemRxiv on 21 August 2024; DOI: <a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2024-lvvhf\">26434\/chemrxiv-2024-lvvhf<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>139.<\/strong> Kroupova, A., Spiteri, V.A., Rutter, Z.J., Furihata, H., Darren, D., Ramachandran, S., Chakraborti, S., Haubrich, K., Pethe, J., Gonzales, D., Wijaya, A.J., Rodriguez-Rios, M., Sturbaut, M., Lynch, D.M., Farnaby, W., Nakasone, M.A., Zollman, D.*, Ciulli, A.*<\/p>\n\n\n\n<p>Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-024-52871-9\"><em>Nat Commun.<\/em> <strong>2024<\/strong> Oct 15;<em>15(1)<\/em>:8885.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39406745\/\">39406745<\/a>&nbsp; <\/span><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:&nbsp;<\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11480361\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11480361<\/a><\/span><\/li>\n\n\n\n<li>Pre-print first posted at BioRxiv on 17 January 2024; 2024.01.17.575503; doi: <a href=\"https:\/\/doi.org\/10.1101\/2024.01.17.575503\">1101\/2024.01.17.575503<\/a><\/li>\n\n\n\n<li>Featured in the <a href=\"https:\/\/www.dundee.ac.uk\/stories\/dundee-cut-and-sew-process-can-accelerate-drug-design\">UoD<\/a> Stories website<\/li>\n\n\n\n<li>His6-TEV-CRBN-midi (<a href=\"https:\/\/www.addgene.org\/215330\/\">Plasmid #215330<\/a>) is now available on Addgene.<\/li>\n\n\n\n<li>X-ray crystallography data generated in this study have been deposited in the Protein Data Bank (PDB) under accession codes: <a href=\"https:\/\/www.rcsb.org\/structure\/8rq1\">8RQ1<\/a> (apo CRBNmidi), <a href=\"https:\/\/www.rcsb.org\/structure\/8rq8\">8RQ8<\/a> (CRBNmidi:mezigdomide), <a href=\"https:\/\/www.rcsb.org\/structure\/8rq9\">8RQ9<\/a> (CRBNmidi:CFT-1297:BRD4BD2), <a href=\"https:\/\/www.rcsb.org\/structure\/8rqa\">8RQA<\/a> (CRBNmidi:lenalidomide), <a href=\"https:\/\/www.rcsb.org\/structure\/8rqc\">8RQC<\/a> (CRBNmidi:mezigdomide:IKZF1ZF2), <a href=\"https:\/\/www.rcsb.org\/structure\/9gao\">9GAO<\/a> (CRBNmidi:compound 1).<\/li>\n<\/ul>\n\n\n\n<p><strong>138.<\/strong> Crowe, C., Nakasone, M.A., Chandler, S., Craigon,C., Sathe, G., Tatham, M.H., Makukhin, N., Hay, R.T., Ciulli, A.*<\/p>\n\n\n\n<p>Mechanism of degrader-targeted protein ubiquitinability<\/p>\n\n\n\n<div><a href=\"https:\/\/www.science.org\/doi\/full\/10.1126\/sciadv.ado6492\"><em>Sci Adv.<\/em> <strong>2024<\/strong> Oct 11;<em>10(41)<\/em>:eado6492.<\/a><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39392888\/\">39392888<\/a>&nbsp; <\/span><span class=\"identifier pmc\"><span class=\"id-label\">PMCID:&nbsp;<\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11468923\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11468923<\/a><\/span><\/li>\n\n\n\n<li>Pre-print first posted at BioRxiv on 5 February 2024; 2024.02.05.578957; doi: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.02.05.578957v1\">1101\/2024.02.05.578957<\/a><\/li>\n\n\n\n<li>Featured in the <a href=\"https:\/\/www.dundee.ac.uk\/stories\/researchers-reveal-new-levels-detail-targeted-protein-degradation\">UoD<\/a> Stories website<\/li>\n\n\n\n<li>Covered in Ian Churcher\u2019s <a href=\"https:\/\/www.janusdrugdiscovery.com\/240219-octonary-complexes\/\">blog<\/a><\/li>\n\n\n\n<li>Electron microscopy reconstructions have been deposited to the Electron Microscopy Databank (EMDB) under accession codes <a href=\"https:\/\/www.ebi.ac.uk\/emdb\/EMD-19569\">EMD-19569<\/a> and <a href=\"https:\/\/www.ebi.ac.uk\/emdb\/EMD-19567\">EMD-19567<\/a>. Atomic models have been deposited to the PDB under IDs <a href=\"https:\/\/www.rcsb.org\/structure\/8RWZ\">8RWZ<\/a> (Open non-crosslinked structure Brd4BD2-MZ1-(NEDD8)-CRL2VHL) and <a href=\"https:\/\/www.rcsb.org\/structure\/8RX0\">8RX0<\/a> (Closed crosslinked structure of (NEDD8)-CRL2VHL-MZ1-Brd4BD2-Ub(G76S, K48C)-UBE2R1(C93K, S138C, C191S, C223S)-Ub).<\/li>\n<\/ul>\n\n\n\n<p><strong>137.<\/strong> Popow, J., Farnaby, W., Gollner, A., Kofink, C., Fischer, G., Wurm, M., Zollman, D., Wijaya, A., Mischerikow, N., Hasenoehrl, C., Prokofeva, P., Arnhof, H., Arce-Solano, S., Bell, S., Boeck, G., Diers, E., Frost, A.B., Goodwin-Tindall, J., Karolyi-Oezguer, J., Khan, S., Klawatsch, T., Koegl, M., Kousek, R., Kratochvil, B., Kropatsch, K., Lauber, A.A., McLennan, R., Olt, S., Peter, D., Petermann, O., Roessler, V., Stolt-Bergner, P., Strack, P., Strauss, E., Trainor, N., Vetma, V., Whitworth, C., Zhong, S., Quant, J., Weinstabl, H., Kuster, B., Ettmayer, P.*, Ciulli, A.*<\/p>\n\n\n\n<p>Targeting cancer with small-molecule pan-KRAS degraders<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1126\/science.adm8684\"><em>Science<\/em> <strong>2024<\/strong> Sep 20;<em>385(6715)<\/em>:1338-1347.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39298590\/\">39298590<\/a><\/li>\n\n\n\n<li>Pre-print first posted at BioRxiv on 26 October 2023;&nbsp;doi: <a href=\"https:\/\/doi.org\/10.1101\/2023.10.24.563163\">1101\/2023.10.24.563163<\/a><\/li>\n\n\n\n<li>Covered in <a href=\"https:\/\/www.dundee.ac.uk\/stories\/university-dundee-research-shows-potential-breakthrough-hard-treat-cancers\">UoD<\/a> Stories website<\/li>\n\n\n\n<li>Featured in the same issue of Science as Perspective <a href=\"https:\/\/doi.org\/10.1126\/science.ads2150\">\u201cKRAS takes the road to destruction\u201d<\/a><\/li>\n\n\n\n<li>Featured in <a href=\"https:\/\/cen.acs.org\/pharmaceuticals\/drug-discovery\/Degrader-takes-forms-KRas\/102\/web\/2024\/09\">Chemical &amp; Engineering News<\/a><\/li>\n\n\n\n<li>Highlighted in <a href=\"https:\/\/doi.org\/10.1158\/2159-8290.CD-RW2024-118\">Cancer Discovery Research Watch<\/a><\/li>\n\n\n\n<li>Highlighted in <a href=\"https:\/\/doi.org\/10.1038\/s41587-024-02445-3\">Nature Biotechnology<\/a><\/li>\n\n\n\n<li>X-ray crystallography data generated in this study have been deposited in the Protein Data Bank (PDB) under accession codes: <a href=\"https:\/\/www.rcsb.org\/structure\/8QUG\">8QUG<\/a> (KRAS-G12C in Complex with Compound 1), <a href=\"https:\/\/www.rcsb.org\/structure\/8QW6\">8QW6<\/a> (compound 3 in complex with VCB (pVHL:ElonginC:ElonginB) and KRAS G12V C118S GDP), <a href=\"https:\/\/www.rcsb.org\/structure\/8QW7\">8QW7<\/a> (compound 4 in complex with KRAS G12V C118S GDP and VCB), <a href=\"https:\/\/www.rcsb.org\/structure\/8QVU\">8QVU<\/a> (ACBI3 in complex with KRAS G12D C118S GDP and VCB).<\/li>\n\n\n\n<li>Cryo-EM density maps have been deposited in the Electron Microscopy Databank (EMDB) under accession code <a href=\"https:\/\/www.ebi.ac.uk\/emdb\/EMD-18657\">EMD-18657<\/a>. The atomic model is deposited to the PDB under ID <a href=\"https:\/\/www.rcsb.org\/structure\/8QU8\">8QU8<\/a> (PROTAC-mediated complex of KRAS with VHL\/Elongin-B\/Elongin-C\/Cullin-2\/Rbx1).<\/li>\n\n\n\n<li>Our pan-KRAS VHL-based PROTAC degrader <a href=\"https:\/\/www.opnme.com\/molecules\/pan-kras-protac-acbi3\">ACBI3<\/a> (together with its negative control cis-ACBI3) are available from Boehringer Ingelheim\u2019s OpnMe Portal: order for free, no strings attached!<\/li>\n<\/ul>\n\n\n\n<p><strong>136.<\/strong> Freemantle, J.B., Shah, D., Lynch, D.M., Ciulli, A., Hundal, H.S., Hardie, D.G.<\/p>\n\n\n\n<p>The pro-drug C13 activates AMPK by two distinct mechanisms<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1042\/bcj20240425\"><em>Biochem. J.<\/em> <strong>2024<\/strong>, Sep 18;<em>481(18)<\/em>:1203-1219.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><span class=\"identifier pubmed\"><span class=\"id-label\">PMID:&nbsp;<\/span><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39222030\/\">39222030<\/a><\/span>&nbsp; PMCID: <a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11555695\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC11555695<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>135.<\/strong> Hatoyama, Y., Islam, M., Bond, A.G., Hayashi, K.-I., Ciulli, A., Kanemaki, M.T.<\/p>\n\n\n\n<p>Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s44319-024-00224-4\"><em>EMBO Rep.,<\/em> <strong>2024<\/strong> Sep;<em>25(9)<\/em>:4062-4077. <\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39179892\/\">39179892<\/a> PMCID: <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11387839\/\">PMC11387839<\/a><\/li>\n\n\n\n<li>Pre-print first posted at <em>BioRxiv<\/em> on 22 March <strong>2024<\/strong>; doi: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.03.20.586026v1\">10.1101\/2024.03.20.586026<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>134.<\/strong> Cavalli, A.,* Ciulli, A.*<\/p>\n\n\n\n<p>Editorial overview: New concept in drug discovery<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.sbi.2024.102911\"><em>Curr. Opin. Struct. Biol.<\/em>&nbsp;<strong>2024<\/strong>,&nbsp;<em>88<\/em>, 102911<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39168047\/\">39168047<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>133<\/strong>. Vetma, V., Casarez-Perez, L., Elia\u0161, J., Stingu, A., Kombara, A., Gmaschitz, T., Braun, N., Ciftci, T., Dahmann, G., Diers, E., Gerstberger, T., Greb, P., Kidd, G., Kofink, C., Puoti, I, Spiteri, V., Trainor, N., Westermaier, Y., Whitworth, C., Ciulli, A., Farnaby, W., McAulay, K., Frost, A.B., Chessum, N., Koegl, M.<\/p>\n\n\n\n<p>Confounding Factors in Targeted Degradation of Short-Lived Proteins<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acschembio.4c00152\"><em>ACS Chem. Biol. <\/em><strong>2024<\/strong> Jul 19;<em>19(7)<\/em>:1484-1494.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38958654\/\">38958654<\/a><\/li>\n\n\n\n<li>Pre-print first posted at <em>BioRxiv<\/em> on 22 February <strong>2024<\/strong>; doi: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2024.02.19.581012v1\">10.1101\/2024.02.19.581012<\/a><\/li>\n\n\n\n<li>Listed as 2nd Most Read Article in the journal (1-month timeframe, Aug 2024)<\/li>\n\n\n\n<li>Highlighted in Derek Lowe\u2019s blog <a href=\"https:\/\/www.science.org\/content\/blog-post\/protein-degradation-focus\">In the Pipeline<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>132<\/strong>. Pierri, M., Liu, X., Kroupova, A., Rutter, Z., Hallatt, A.J., Ciulli, A.*<\/p>\n\n\n\n<p>Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.bmcl.2024.129861\"><em>Bioorg. Med. Chem. Lett.<\/em> <strong>2024<\/strong> Sep 15;<em>110<\/em>:129861.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38942127\/\">38942127<\/a><\/li>\n\n\n\n<li>2nd Most Downloaded Article in the journal (Dec 2024)<\/li>\n\n\n\n<li>X-ray crystallographic atomic coordinates and structure factors are available at the Protein Data Bank (PDB) under accession codes <a href=\"https:\/\/www.rcsb.org\/structure\/9EQM\">9EQM<\/a> (pVHL:ElonginC:ElonginB complex (VCB) in complex with compound MP-1-21) and <a href=\"https:\/\/www.rcsb.org\/structure\/9eqj\">9EQJ<\/a> (VCB in complex with compound MP-1-39).<\/li>\n<\/ul>\n\n\n\n<p><strong>131.<\/strong> Diehl, C. J., Salerno, A., Ciulli, A.*<\/p>\n\n\n\n<p>Ternary Complex-Templated Dynamic Combinatorial Chemistry for the Selection and Identification of Homo-PROTACs.<\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202319456\"><em>Angew. Chem. Int. Ed. Engl.<\/em> <strong>2024<\/strong> Jun 17;<em>63(25)<\/em>:e202319456.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38626385\/\">38626385<\/a><\/li>\n\n\n\n<li>Pre-print first posted at <em>ChemRxiv<\/em> on 16 December <strong>2023<\/strong>; doi: <a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2023-tz70z\">10.26434\/chemrxiv-2023-tz70z<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>130.<\/strong> Hsia, O., Hinterndorfer, M., Cowan, A.D., Iso, K., Ishida, T., Sundaramoorthy, R., Nakasone, M.A., Imrichova, H., Sch\u00e4tz, C., Rukavina, A., Husnjak, K., Wegner, M., Correa-S\u00e1ez, A., Craigon, C., Casement, R., Maniaci, C., Testa, A., Kaulich, M., Dikic, I., Winter, G.E.,* Ciulli, A.*<\/p>\n\n\n\n<p>Targeted protein degradation via intramolecular bivalent glues<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41586-024-07089-6\"><em>Nature<\/em> <strong>2024<\/strong> Mar;<em>627(8002)<\/em>:204-211. <\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38383787\/\">38383787<\/a><span class=\"identifier pmc\"><span class=\"id-label\">&nbsp; PMCID: <\/span><a data-ga-category=\"full_text\" data-ga-action=\"PMCID\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10917667\/\" target=\"_blank\" rel=\"noopener\" class=\"id-link\">PMC10917667<\/a><\/span><\/li>\n\n\n\n<li>Preprint first posted at BioRxiv on 14 February 2023 version 1: DOI: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.02.14.528511v1\">10.1101\/2023.02.14.528511v1<\/a><\/li>\n\n\n\n<li>Preprint&nbsp; version 2&nbsp; DOI: <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2023.02.14.528511v2\">10.1101\/2023.02.14.528511v2<\/a><\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/www.dundee.ac.uk\/stories\/protein-sandwich-could-transform-cancer-drug-discovery\">UoD<\/a>&nbsp;News website<\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/cemm.at\/news\/n\/new-system-triggers-cellular-waste-disposal\">CeMM<\/a>&nbsp;News website<\/li>\n\n\n\n<li>Highlighted in&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/d41573-024-00044-0\">Nature Reviews Drug Discovery<\/a><\/li>\n\n\n\n<li>Highlighted in <a href=\"https:\/\/doi.org\/10.1158\/2159-8290.CD-RW2024-040\">Cancer Discovery Research Watch<\/a><\/li>\n\n\n\n<li>Highlighted in <a href=\"https:\/\/doi.org\/10.1038\/s41589-024-01649-7\">Nature Chemical Biology<\/a><\/li>\n\n\n\n<li>Featured in BMG Labtech\u2019s post on <a href=\"https:\/\/www.news-medical.net\/health\/Investigating-intramolecular-bivalent-glues-through-TR-FRET-assays.aspx\">NewsMedical.net<\/a><\/li>\n\n\n\n<li>Cryo-EM density maps are deposited in the EMDB with the accession code <a href=\"https:\/\/www.ebi.ac.uk\/emdb\/EMD-17172\">EMD-17172<\/a>. The atomic model is deposited under Protein Data Bank ID <a href=\"https:\/\/www.rcsb.org\/structure\/8OV6\">8OV6<\/a> (Ternary structure of intramolecular bivalent glue degrader IBG1 bound to BRD4 and DCAF16:DDB1deltaBPB)<\/li>\n\n\n\n<li>Our dual Brd2\/4 intramolecular bivalent glue degrader IBG3 is available from <a href=\"https:\/\/www.tocris.com\/products\/ibg3_8129\">Tocris<\/a> and <a href=\"https:\/\/www.medchemexpress.com\/ibg3.html\">MedChemExpress<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2023<\/strong><\/h3>\n\n\n\n<p><strong>129.<\/strong>&nbsp;Ciulli, A.*, O\u2019Connor, S.*, Chung, C.-W., Hartung, I. V., Testa, A., Daniels, D. L., Heitman, L. H.*<\/p>\n\n\n\n<p>The 17th EFMC Short Course on Medicinal Chemistry on Small Molecule Protein Degraders<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1002\/cmdc.202300464\"><em>ChemMedChem<\/em>&nbsp;<strong>2023<\/strong>, e202300464.<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37817354\/\">37817354<\/a><\/li>\n\n\n\n<li>Read more about this report <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2023\/10\/10\/we-report-in-chemmedchem-on-our-first-ever-efmc-short-course-on-targeted-protein-degraders\/\">here<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>128<\/strong>. Ramachandran, S., Makukhin, N., Haubrich, K., Nagala, M., Forrester, B., Lynch, D.M., Casement, R., Testa, A., Bruno, E., Gitto, R., Ciulli, A. *<\/p>\n\n\n\n<p>Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-41894-3\"><em>Nat. Commun<\/em>.&nbsp;<strong>2023<\/strong>,&nbsp;<em>14<\/em>, 6345<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37816714\/\">37816714<\/a>&nbsp; PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10564737\/\">PMC10564737<\/a><\/li>\n\n\n\n<li>Preprint version 1&nbsp; &nbsp;DOI:&nbsp;<a href=\"https:\/\/chemrxiv.org\/engage\/chemrxiv\/article-details\/634d2ea6e3f3ee7bca5d33ad\">10.26434\/chemrxiv-2022-bvj80<\/a><\/li>\n\n\n\n<li>Preprint&nbsp; version 2&nbsp; DOI:&nbsp;<a href=\"https:\/\/chemrxiv.org\/engage\/chemrxiv\/article-details\/64d9dfef4a3f7d0c0d246f53\">10.26434\/chemrxiv-2022-bvj80-v2<\/a><\/li>\n\n\n\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2023\/10\/23\/new-paper-nature-communications-structure-based-design-of-a-phosphotyrosine-masked-covalent-ligand\/\">here<\/a><\/li>\n\n\n\n<li>Covered in <a href=\"https:\/\/www.dundee.ac.uk\/stories\/trojan-horse-chemical-tool-allows-researchers-target-undruggable-proteins\">UoD Stories<\/a> and <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2023\/10\/27\/trojan-horse-chemical-tool-to-target-undruggable-proteins\/\">SLS News<\/a> websites<\/li>\n\n\n\n<li>Highlighted in Nature Chemical Biology; doi: <a href=\"https:\/\/doi.org\/10.1038\/s41589-024-01557-w\">10.1038\/s41589-024-01557-w<\/a><\/li>\n\n\n\n<li>X-ray crystallographic atomic coordinates and structure factors are available at the PDB under accession codes&nbsp;<a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLP\">7ZLP&nbsp;<\/a>(compound 9 soaked to SOCS2:ElonginC:ElonginB complex (SBC2)), <a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLN\">7ZLN<\/a>&nbsp;(compound 11 soaked to SBC2),&nbsp;<a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLO\">7ZLO<\/a>&nbsp;(compound 12 soaked to SBC2),&nbsp;<a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLR\">7ZLR<\/a>&nbsp;(compound 13 soaked to SBC2),&nbsp;<a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLS\">7ZLS<\/a>&nbsp;(compound 13 co-crystallized in complex with SBC2),&nbsp;<a href=\"https:\/\/www1.rcsb.org\/structure\/7ZLM\">7ZLM<\/a> (compound MN551 co-crystallized in complex with SBC2)<\/li>\n\n\n\n<li>Our SOCS2 covalent inhibitor is available from MedChemExpress: unprotected <a href=\"https:\/\/www.medchemexpress.com\/mn551.html\">MN551<\/a> for biophysical\/structural studies or work ex-vivo \/ in cell lysates; and POM-protected cell-penetrant prodrug version <a href=\"https:\/\/www.medchemexpress.com\/mn714.html\">MN714<\/a> for cellular studies<\/li>\n\n\n\n<li>MN714 \/ MN551 is qualified within EUbOpen as a Chemical Probe for SOCS2, more info in the <a href=\"https:\/\/www.eubopen.org\/sites\/www.eubopen.org\/files\/chemical-probes\/EUbOPEN_ProbeSheet_MN551_MN714_v1.pdf\">ProbeSheet<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>127.<\/strong>&nbsp;Vu, L.P., Diehl, C.J., Casement, R., Bond, A.G., Steinebach, C., Stra\u0161ek, N., Bricelj, A., Perdih, A., Schnakenburg, G., Sosi\u010d, I., Ciulli, A.*, G\u00fctschow, M*<\/p>\n\n\n\n<p>Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1alpha (HIF-1alpha) Stabilizers<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acs.jmedchem.3c00434\"><em>J. Med. Chem.<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>66 (18)<\/em>, 12776-12811<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37708384\/\">37708384<\/a>&nbsp; PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10544018\/\">PMC10544018<\/a><\/li>\n\n\n\n<li>Pre-print first posted at ChemRxiv on 07 March 2023; DOI:&nbsp;<a href=\"https:\/\/chemrxiv.org\/engage\/chemrxiv\/article-details\/6403a25037e01856dc276be5\">10.26434\/chemrxiv-2023-5gbb6<\/a><\/li>\n\n\n\n<li>Newer version 2 available from August 1st, 2023 at&nbsp;<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2023-5gbb6-v2\">10.26434\/chemrxiv-2023-5gbb6-v2<\/a><\/li>\n\n\n\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2023\/09\/23\/our-new-paper-on-vhl-inhibitors\/\">here<\/a><\/li>\n\n\n\n<li>The coordinates and structure factors of the associated co-crystal structure of the binary complexes between VHL and inhibitors 30, 33, and 37&nbsp;are available in the PDB with accession codes&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/8cqk\">8CQK<\/a>,&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/8CQL\">8CQL<\/a>, and&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/8CQE\">8CQE<\/a>, respectively.<\/li>\n<\/ul>\n\n\n\n<p>(<strong>126.<\/strong> Ramachandran et al. <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/book-chapters-and-patents\/\">book chapter<\/a>)<\/p>\n\n\n\n<p><strong>125.<\/strong>&nbsp;Liu, X. Ciulli, A.*<\/p>\n\n\n\n<p>Proximity-Based Modalities for Biology and Medicine<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1021\/acscentsci.3c00395\"><em>ACS Cent. Sci.<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>9 (7)<\/em>, 1269\u20131284<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37521793\/\">37521793<\/a>&nbsp; PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10375889\/\">PMC10375889<\/a><\/li>\n\n\n\n<li>See Figures&nbsp;<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2023\/07\/28\/now-published-in-acs-central-science\/\">here<\/a><\/li>\n\n\n\n<li>Listed as 1st&nbsp;<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=acscii\">Most Read Article<\/a>&nbsp;in the journal (1-month timeframe, Aug 2023)<\/li>\n<\/ul>\n\n\n\n<p><strong>124.<\/strong>&nbsp;Haubrich, K., Spiteri, V.A., Farnaby, W., Sobott, F., Ciulli, A.*<\/p>\n\n\n\n<p>Breaking free from the crystal lattice: Structural biology in solution to study protein degraders<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.sbi.2023.102534\"><em>Curr. Opin. Struct. Biol.,<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>79<\/em>,&nbsp;102534<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36804675\/\">36804675<\/a><\/li>\n\n\n\n<li>Ranked amongst&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/journal\/current-opinion-in-structural-biology\">Most Downloaded Articles<\/a>&nbsp;in the journal (August 2023)<\/li>\n<\/ul>\n\n\n\n<p><strong>123.<\/strong>&nbsp;Wijaya, A.J., Farnaby, W., Ciulli, A.*<\/p>\n\n\n\n<p>Crystallization of VHL-based PROTAC-induced ternary complexes<\/p>\n\n\n\n<p><a href=\"http:\/\/doi.org\/10.1016\/bs.mie.2022.10.005\"><em>Methods in Enzymology&nbsp;<\/em><strong>2023<\/strong>,&nbsp;<em>681,<\/em>&nbsp;241\u2013<\/a><a href=\"http:\/\/doi.org\/10.1016\/bs.mie.2022.10.005\">263<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36764760\/\">36764760<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>122.<\/strong>&nbsp;Hanzl, A., Casement, R., Imrichova, H., Hughes, S.J., Barone, E., Testa, A., Bauer, S., Wright, J., Brand, M., Ciulli, A.*, Winter, G.E.*<\/p>\n\n\n\n<p>Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41589-022-01177-2\"><em>Nat. Chem. Biol.<\/em>&nbsp;<strong>2023<\/strong>,&nbsp;<em>19 (3)<\/em>, 323-333<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36329119\/\">36329119<\/a>&nbsp; PMCID:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7614256\/\">&nbsp;PMC7614256<\/a><\/li>\n\n\n\n<li>Pre-print posted at BioRxiv on 14 April 2022; DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2022.04.14.488316\">https:\/\/doi.org\/10.1101\/2022.04.14.488316<\/a><\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/www.dundee.ac.uk\/stories\/study-raises-hopes-preventing-resistance-cancer-therapy\">UoD<\/a>&nbsp;News website<\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/cemm.at\/news\/n\/preventing-resistance-in-cancer-therapy\">CeMM<\/a>&nbsp;News website<\/li>\n\n\n\n<li>Highlighted in&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/d41573-022-00202-2\">Nature Reviews Drug Discovery<\/a><\/li>\n\n\n\n<li>Featured in a Spotlight article by Nico Thoma and colleagues in&nbsp;<a href=\"https:\/\/doi.org\/10.1016\/j.tips.2023.02.001\">Trends in Pharmacological Sciences<\/a><\/li>\n\n\n\n<li>Atomic coordinates and structure factors for the ternary complex crystal structure VHL:AT7:Brd4-BD2 are available at the PDB under accession code&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/7ZNT\">7ZNT<\/a>.<\/li>\n<\/ul>\n\n\n\n<p>(<strong>121.<\/strong> Hsia &amp; Ciulli <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciullipublications\/book-chapters-and-patents\/\">book chapter<\/a>)<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>2022<\/strong><\/h3>\n\n\n\n<p><strong>120.<\/strong>&nbsp;Kofink, C., Trainor, N., Mair, B., Wo\u0308hrle, S., Wurm, M., Mischerikow, N., Roy, M., Bader, G., Greb, P., Garavel, G., Diers, E., McLennan, R., Whitworth, C., Vetma, V., Rumpel, K., Scharnweber, M., Fuchs, J.E., Gerstberger, T., Cui, Y., Gremel, G., Chetta, P., Hopf, S., Budano, N., Rinnenthal, J., Gmaschitz, G., Mayer, M., Koegl, M., Ciulli, A., Weinstabl, H., Farnaby, W.<\/p>\n\n\n\n<p>A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-022-33430-6\"><em>Nat. Commun.&nbsp;<\/em><strong>2022<\/strong><em>,&nbsp;13<\/em>, 5969<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36216795\/\">36216795<\/a>&nbsp;PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9551036\/\">PMC9551036<\/a><\/li>\n\n\n\n<li>Pre-print posted at ChemRxiv on 1 February 2022;&nbsp;DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2022-q63s3\">10.26434\/chemrxiv-2022-q63s3<\/a><\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/www.dundee.ac.uk\/stories\/discovery-raises-hopes-further-anti-cancer-breakthroughs\">UoD<\/a> and <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/10\/12\/discovery-raises-hopes-of-further-anti-cancer-breakthroughs\/\">SLS<\/a> News website<\/li>\n\n\n\n<li>Featured in a Comment article by John Harling and Chris Tinworth in&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s41467-023-36238-0\">Nature Communication<\/a><\/li>\n\n\n\n<li>X-ray co-crystal structures data have been deposited to the PDB under accession codes&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/7Z78\">7Z78<\/a>&nbsp;(compound 4 in complex with SMARCA2-BD),&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/7Z6L\">7Z6L<\/a> (VCB (pVHL:ElonginC:ElonginB complex): compound 5: SMARCA2-BD ternary complex), <a href=\"https:\/\/www.rcsb.org\/structure\/7Z77\">7Z77<\/a>&nbsp;(VCB: compound 6: SMARCA2-BD ternary complex), and&nbsp;<a href=\"https:\/\/www.rcsb.org\/structure\/7Z76\">7Z76<\/a>&nbsp;(VCB: compound 10: SMARCA2-BD ternary complex).<\/li>\n\n\n\n<li>Our SMARCA2 VHL-based PROTAC degrader <a href=\"https:\/\/www.opnme.com\/molecules\/smarca2-acbi2\">ACBI2<\/a> (together with its negative control cis-ACBI2) are available from Boehringer Ingelheim\u2019s OpnMe Portal: order for free, no strings attached!<\/li>\n\n\n\n<li>Find out more about <a href=\"https:\/\/www.chemicalprobes.org\/acbi2\">ACBI2<\/a> in the Chemical Probes Portal<\/li>\n<\/ul>\n\n\n\n<p><strong>119.<\/strong>&nbsp;Cipriano, A., Milite, C., Feoli, A., Viviano, M., Pepe, G., Campiglia, P., Sarno, G., Picaud, S., Imaide, S., Makukhin, N., Filippakopoulos, P., Ciulli, A., Castellano, S., Sbardella, G.<\/p>\n\n\n\n<p>Discovery of benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1002\/cmdc.202200343\"><em>ChemMedChem<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>17 (20)<\/em>, e202200343<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36040095\/\">36040095<\/a>&nbsp;PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9826262\/\">PMC9826262<\/a><\/li>\n\n\n\n<li>See front cover&nbsp;<a href=\"https:\/\/doi.org\/10.1002\/cmdc.202200528\">here<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>118.<\/strong>&nbsp;Liu, X., Kalogeropulou, A., Domingos, S., Makukhin, N., Nirujogi, R., Singh, F., Shpiro, N., Saalfrank, A., Sammler, E., Ganley, I., Moreira, R., Alessi, D.*, Ciulli, A.*<\/p>\n\n\n\n<p>Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Oral bioavailable and Blood Brain Barrier Penetrant PROTAC Degrader of Leucine Rich Repeat Kinase 2 (LRRK2)<\/p>\n\n\n\n<p><a href=\"http:\/\/doi.org\/10.1021\/jacs.2c05499\"><em>J. Am. Chem. Soc.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>144 (37)<\/em>, 16930\u201316952<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36007011\/\">&nbsp;36007011<\/a>&nbsp;PMCID:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9501899\/\">&nbsp;PMC9501899<\/a><\/li>\n\n\n\n<li>Pre-print posted at ChemRxiv on 23 May 2022; DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.26434\/chemrxiv-2022-4gzm0-v2\">10.26434\/chemrxiv-2022-4gzm0<\/a><\/li>\n\n\n\n<li>Covered in&nbsp;<a href=\"https:\/\/www.dundee.ac.uk\/stories\/research-breakthrough-parkinsons-disease\">UoD<\/a> and <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/08\/08\/review-on-vhl-ligands\/\">SLS<\/a> Stories websites<\/li>\n\n\n\n<li>Listed as 3rd&nbsp;<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=month&amp;journalCode=jacsat\">Most Read Article<\/a>&nbsp;in the journal (1-month timeframe, Sept 2022)<\/li>\n\n\n\n<li>Listed as one of the&nbsp;<a href=\"https:\/\/pubs.acs.org\/action\/showMostReadArticles?topArticlesType=recent&amp;journalCode=jacsat\">Most Read Articles<\/a>&nbsp;in the journal within the 12-month timeframe (July 2023)<\/li>\n\n\n\n<li>Our LRRK2 PROTAC degrader <a href=\"https:\/\/www.medchemexpress.com\/xl01126.html\">XL01126<\/a> is available from MedChemExpress<\/li>\n\n\n\n<li>Find out more about XL01126 in the <a href=\"https:\/\/www.chemicalprobes.org\/xl01126\">Chemical Probes Portal<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>117.<\/strong>&nbsp;Diehl, C.J., Ciulli, A.*<\/p>\n\n\n\n<p>Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1039\/D2CS00387B\"><em>Chem. Soc. Rev.&nbsp;<\/em><strong>2022<\/strong>,&nbsp;<em>51<\/em>, 8216-8257<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35983982\/\">35983982<\/a>&nbsp;PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9528729\/\">PMC9528729<\/a><\/li>\n\n\n\n<li>See front cover&nbsp;<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/08\/08\/review-on-vhl-ligands\/\">here<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>116.<\/strong>&nbsp;Rasmussen, S.V.,Jin, J.X., Bickford, L.R., Woods, A.D., Sahm, F., Crawford, K.A., Nagamori, K., Goto, H., Torres, K.E., Sidoni, A., Rudzinski, E.R., Thway, K., Jones, R.L., Ciulli, A., Wright, H., Lathara, M., Srinivasa, G., Kannan, K., Huang, P.H., Gr\u00fcnewald, T.G.P., Berlow, N.E., Keller, C.<\/p>\n\n\n\n<p>Functional genomic analysis of epithelioid sarcoma reveals distinct proximal and distal subtype biology<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1002\/ctm2.961\"><em>Clin. Transl. Med.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>12 (7)<\/em>, e961<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35839307\/\">35839307<\/a>&nbsp;PMCID:&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc9286527\/\">PMC9286527<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>115.<\/strong>&nbsp;Gollner, A., K\u00f6ster, M., Nicklin, P., Trieselmann, T., Klein, E., Vlach, J., Heine, C., Grundl, M., Ramharter, J., Wyatt, D., Chaturvedi, M., Ciulli, A., Carter, K.C., M\u00fcller, S., Bischoff, D., Ettmayer, P., Haaksma, E., Mack, J., McConnell, D., Stenkamp, D., Weinstabl, H., Zentgraf, M., Wood, C.R., Montel, F. OpnMe.com: a digital initiative for sharing tools with the biomedical research community. <a href=\"https:\/\/doi.org\/10.1038\/d41573-022-00071-9\"><em>Nat. Rev. Drug Discov.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>21<\/em>, 475-476<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35459938\/\">35459938<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>114. <\/strong>Grohmann, C., Magtoto, C.M., Walker, J.R., Chua, N.K., Gabrielyan, A., Hall, M., Cobbold, S.A., Mieruszynski, S., Brzozowski, M., Simpson, D.S., Dong, H., Dorizzi, B., Jacobsen, A.V., Morrish, E., Silke, N., Murphy, J.M., Heath, J.K., Testa, A., Maniaci, C., Ciulli, A., Lessene, G., Silke, J., Feltham, R. Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms. <a href=\"https:\/\/doi.org\/10.1038\/s41467-022-29670-1\"><em>Nat. Commun.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>13<\/em>, 2073<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35440107\/\">35440107<\/a>&nbsp;PMCID:<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9019100\/\">&nbsp;PMC9019100<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>113<\/strong>. Cowan, A.D., Ciulli, A.* Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory. <a href=\"https:\/\/doi.org\/10.1146\/annurev-biochem-032620-104421\"><em>Annu. Rev. Biochem.<\/em>,&nbsp;<strong>2022<\/strong>,&nbsp;<em>91<\/em>, 295-319<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35320687\/\">35320687<\/a><\/li>\n\n\n\n<li>See Figures <a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/03\/24\/newly-published-in-annual-reviews-of-biochemistry\/\">here<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>112.<\/strong>&nbsp;Webb, T., Craigon, C., Ciulli, A.* Targeting Epigenetic Modulators Using PROTAC Degraders: Current Status and Future Perspective. <a href=\"http:\/\/doi.org\/10.1016\/j.bmcl.2022.128653\"><em>Bioorg. Med. Chem. Lett.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>63<\/em>, 128653<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35257896\/\">35257896<\/a><\/li>\n\n\n\n<li>See Figures&nbsp;<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/04\/03\/review-on-targeting-epigenetic-modulators\/\">here<\/a><\/li>\n\n\n\n<li>Read the article open access before April 29, 2022 via the personalized&nbsp;<a href=\"https:\/\/authors.elsevier.com\/a\/1ejT0,LsIFtNIJ\">Share Link<\/a><\/li>\n\n\n\n<li>Listed amongst the top&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/journal\/bioorganic-and-medicinal-chemistry-letters\">Most Downloaded Articles<\/a>&nbsp;in the Journal of the last 90 days (Sept 2022)<\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>111.<\/strong>&nbsp;Liu, X., Ciulli, A.* Targeted protein stabilization: DUB be good to me. <a href=\"http:\/\/doi.org\/10.1038\/s41589-022-00978-9\"><em>Nat. Chem. Biol.<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>18 (4)<\/em>, 358-359<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37039823\/\">37039823<\/a><\/li>\n\n\n\n<li>News &amp; Views article on&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s41589-022-00971-2\">Henning et al.&nbsp;<em>Nat. Chem. Biol.<\/em>&nbsp;2022<\/a><\/li>\n\n\n\n<li>Read the article Open Access as SharedIt version&nbsp;<a href=\"https:\/\/rdcu.be\/cHGZA\">here<\/a><\/li>\n\n\n\n<li>See Figure and links&nbsp;<a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulli2022\/02\/24\/dub-be-good-to-me-is-now-published-in-nat-chem-biol\/\">here<\/a><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><strong>110.<\/strong>&nbsp;Bharathy, N., Cleary, M.M., Kim, J-A., Nagamori, K., Crawford, K.A., Wang, E., Saha, D., Settelmeyer, T.P., Purohit, R., Skopelitis, D., Chang, K., Doran, J.A., Kirschbaum, C.W., Bharathy, S., Crews, D.W., Randolph, M.E., Karnezis, A.N., Hudson-Price, L., Dhawan, J., Michalek, J.E., Ciulli, A.,* Vakoc, C.R. &amp; Keller, C.* SMARCA4 biology in alveolar rhabdomyosarcoma. <a href=\"http:\/\/doi.org\/10.1038\/s41388-022-02205-0\"><em>Oncogene<\/em>&nbsp;<strong>2022<\/strong>,&nbsp;<em>41<\/em>, 1647\u20131656<\/a><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35094009\/\">&nbsp;35094009<\/a>&nbsp;PMCID:&nbsp;<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9985831\/\">PMC998583<\/a>1<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>PubMed Link PubMed list of publications Google Scholar Link Google Scholar Profile Previous Publications 2018-2021 2011-2017 Peer-reviewed, published articles *Corresponding Author 2026 160. Cowan, A.D.,* Jaekel, S.,&nbsp;Ciulli, A..* Scalable insect cell expression and purification screening applied to CRL4-DCAF substrate receptors. Protein Expression and Purification. Available online 4 March 2026, Doi: 10.1016\/j.pep.2026.106907 159. Shaum, J.B., Mu\u00f1oz, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-168","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=168"}],"version-history":[{"count":11,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168\/revisions"}],"predecessor-version":[{"id":4998,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/168\/revisions\/4998"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}