{"id":105,"date":"2023-10-27T11:33:06","date_gmt":"2023-10-27T10:33:06","guid":{"rendered":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/?page_id=105"},"modified":"2026-01-27T16:38:50","modified_gmt":"2026-01-27T16:38:50","slug":"chemical-probes","status":"publish","type":"page","link":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/research\/chemical-probes\/","title":{"rendered":"Chemical Probes"},"content":{"rendered":"<h2>PROTAC degraders<\/h2>\n<h3>BET proteins Brd2, Brd3 and Brd4<\/h3>\n<div class=\"wp-block-group\">\n<div class=\"wp-block-group has-border-color has-palette-color-7-border-color\" style=\"padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2023\/10\/MZ1-final.jpg\" alt=\"BET proteins BRD4, BRD3, BRD2\"\/><\/figure>\n<p>General<\/p>\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulliresearch\/chemical-probes\/mz1\/\">MZ1 BET PROTAC degrader<\/a><\/h4>\n<\/div>\n<div class=\"wp-block-group has-border-color has-palette-color-7-border-color\" style=\"padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2023\/10\/MZP-54.jpg\" alt=\"BET proteins BRD4, BRD3, BRD2\"\/><\/figure>\n<p>General<\/p>\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulliresearch\/chemical-probes\/mzp-54\/\">MZP-54 BET PROTAC degrader<\/a><\/h4>\n<\/div>\n<div class=\"wp-block-group has-border-color has-palette-color-7-border-color\" style=\"padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2023\/10\/MZP-55.jpg\" alt=\"BET proteins BRD4, BRD3, BRD2\"\/><\/figure>\n<p>General<\/p>\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulliresearch\/chemical-probes\/mzp-55\/\">MZP-55 BET PROTAC degrader<\/a><\/h4>\n<\/div>\n<div class=\"wp-block-group has-border-color has-palette-color-7-border-color\" style=\"padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2023\/10\/AT1-copy.jpg\" alt=\"AT1\"\/><\/figure>\n<p>General<\/p>\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulliresearch\/chemical-probes\/at1\/\">AT1 Brd4 PROTAC degrader<\/a><\/h4>\n<\/div>\n<\/div>\n<h2><strong>E3 ubiquitin ligase VHL<\/strong><\/h2>\n<div class=\"wp-block-group\">\n<div class=\"wp-block-group has-border-color has-palette-color-7-border-color\" style=\"padding-top:var(--wp--preset--spacing--40);padding-right:var(--wp--preset--spacing--40);padding-bottom:var(--wp--preset--spacing--40);padding-left:var(--wp--preset--spacing--40)\">\n<figure class=\"wp-block-image\"><img decoding=\"async\" src=\"https:\/\/sites.dundee.ac.uk\/wp-content\/uploads\/sites\/233\/2023\/10\/CM11-copy.jpg\" alt=\"CM11\"\/><\/figure>\n<p>General<\/p>\n<h4 class=\"wp-block-heading\"><a href=\"https:\/\/sites.dundee.ac.uk\/alessio-ciulliresearch\/chemical-probes\/cm11\/\">CM11 VHL Homo-PROTAC degrader<\/a><\/h4>\n<\/div>\n<\/div>\n<h2>Brd 7\/9<\/h2>\n","protected":false},"excerpt":{"rendered":"<p>PROTAC degraders BET proteins Brd2, Brd3 and Brd4 General MZ1 BET PROTAC degrader General MZP-54 BET PROTAC degrader General MZP-55 BET PROTAC degrader General AT1 Brd4 PROTAC degrader E3 ubiquitin ligase VHL General CM11 VHL Homo-PROTAC degrader Brd 7\/9<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":92,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-105","page","type-page","status-publish","hentry"],"blocksy_meta":[],"_links":{"self":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/105","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/comments?post=105"}],"version-history":[{"count":29,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/105\/revisions"}],"predecessor-version":[{"id":4943,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/105\/revisions\/4943"}],"up":[{"embeddable":true,"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/pages\/92"}],"wp:attachment":[{"href":"https:\/\/sites.dundee.ac.uk\/alessio-ciulli\/wp-json\/wp\/v2\/media?parent=105"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}