Trial Information

What is involved if I take part?
This trial will compare the health of people treated with medications with anti-inflammatory properties to people who do not receive any trial medication but continue with their usual bronchiectasis treatment (usual care). Each participant in the trial will receive only one of the trial medications or will receive usual medical care, with no additional trial medication.
The medications we’re using are currently used by the NHS for different reasons. They have been used for a long time and are well tolerated. All these medications have been shown to reduce inflammation in the lungs.

If you agree to take part in the trial, you will be assessed to see if it is ok for you to take all the trial treatments. You will then be allocated by random to one of these treatment options. If any of the trial treatments are not suitable for you, or you don’t want to take any of the medications, you will not be allocated that treatment option. Your treatment option will then be decided at random (like tossing a coin but using a computer).

Participation in the trial is entirely voluntary and you may withdraw at any time.

Depending on the number of participants allocated to each treatment, we might stop adding more participants to some treatment options. We will tell you what treatments are available to you and what treatment you have been allocated.

At each visit you will be seen by a Researcher. Each visit will involve a health check, monitoring of your symptoms, and trial assessments. You will have some blood samples and sputum samples collected. You will also be asked to complete questionnaires and a patient symptom diary.

You will be allocated to receive one of four treatments for 28 days:
• Usual care (no change to treatment)
• Disulfiram (an anti-inflammatory)
• Dipyridamole (an anti-inflammatory)
• Doxycycline (an anti-inflammatory)

You will not be able to choose which trial treatment you are given; this will be decided randomly. You will be told which treatment you have been allocated to.

By taking part you are contributing to medical science and the results may help other people in the future.

Will my taking part in the trial be kept confidential?

Yes. Please follow the links below for further information:
Data Protection – University of Dundee and
Data Protection NHS Tayside